Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

NCT03342326 | Terminated

• 2 other identifiers: 17081172017-A02686-47
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

Conditions

Alzheimer Disease

Keywords

Lexical priming; Healthy Aging

Outcome Measures

Primary Outcomes (1)

• Reaction time difference for the treatment of words that have been presented in sing condition in the exposure phase versus words presented in spoken condition.

  Day 1

Secondary Outcomes (1)

• Reaction time difference for processing words associated with songs presented by their melody alone versus new words (not presented in the exhibition phase).

  Day 1

Study Arms (2)

patient with Alzheimer's Disease

OTHER

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

Other: Exposure to familiar songs; Other: Music Experience Questionnaire; Other: Implicit tasks memory

healthy volunteer

OTHER

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5. 2. Music Experience Questionnaire : questions about the past music training 3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not. 4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Other: Exposure to familiar songs; Other: Music Experience Questionnaire; Other: Implicit tasks memory; Other: Questionnaires

Interventions

Exposure to familiar songs OTHER

3 conditions : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

healthy volunteer; patient with Alzheimer's Disease

Music Experience Questionnaire OTHER

questions about the past music training

healthy volunteer; patient with Alzheimer's Disease

Implicit tasks memory OTHER

2 tests : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

healthy volunteer; patient with Alzheimer's Disease

Questionnaires OTHER

Mini Mental State Examination, 5 words by Dubois and fluence verbal test

healthy volunteer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Presence of diagnostic criteria for Alzheimer's disease
• Age ≥ 65 years
• MMSE (Mini-mental state Examination) ≥ 20

You may not qualify if:

• Unstable clinical presentation or language presentation in the foreground
• Cognitive disorder of etiology different from that of Alzheimer's disease
• Age ≥ 18 years
• Absence of neurological or psychiatric antecedents
• For those aged 65 or over: MMSE (Mini-mental state Examination) greater than or equal to 27; non-pathological performance against the 5 words of Dubois and the verbal fluency test.
• Visual or auditory disorders insufficiently corrected
• Oral or written expression in French insufficient to carry out tests
• Consumption of psychotropic drugs not stabilized

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU de Saint Etienne

Saint-Etienne, 42055, France

Location

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 10, 2017
• First Posted: November 14, 2017
• Study Start: April 3, 2018
• Primary Completion: May 29, 2019
• Study Completion: May 29, 2019
• Last Updated: September 11, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)