Determination of Glycemic Index of Six Greek Honey Grades

NCT03331757 | Completed

• 1 other identifier: 1254
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

This study determined the glycemic index and glycemic load of six Greek honey varieties

Conditions

Potential Abnormality of Glucose Tolerance; Appetitive Behavior

Outcome Measures

Primary Outcomes (1)

• Capillary blood glucose responses

  Clinically useful change in capillary blood glucose, defined as the restoration of glucose within normal limits during the 2hr glucose tolerance test.

  2 hours

Secondary Outcomes (1)

• Subjective appetite rating

  2 hours

Study Arms (7)

Glucose as reference food

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from D-glucose, tested three times, in different weeks as reference food along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Fir honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from fir honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Heather honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from heather honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Citrus honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from citrus honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Pine honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from pine honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Thyme honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from thyme honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Chestnut honey

EXPERIMENTAL

Eleven metabolically healthy, normal weight subjects (male: 2, female: 9) after 10-14 hr fast, consumed 50g available carbohydrate from chestnut honey, tested once, along with 300ml water. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min. The first glucose sample was taken exactly 15min after the first drink.

Other: Glucose as reference food; Other: Fir honey; Other: Heather honey; Other: Citrus honey; Other: Pine honey; Other: Thyme honey; Other: Chestnut honey

Interventions

Glucose as reference food OTHER

Eleven subjects (male: 2, female: 9) consumed 50g glucose diluted in 300ml water, tested three times, in different weeks, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Fir honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of fir honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Heather honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of heather honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Citrus honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of citrus honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Pine honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of pine honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Thyme honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of thyme honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Chestnut honey OTHER

Eleven subjects (male: 2, female: 9) consumed 50g available carbohydrates of chestnut honey diluted in 300ml water, tested once, within 5-10min. Fingertip capillary blood glucose samples were taken at baseline, 15, 30, 45, 60, 90 and 120min.

Chestnut honey; Citrus honey; Fir honey; Glucose as reference food; Heather honey; Pine honey; Thyme honey

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy
• non-smoking
• individuals with normal body mass index (between 18.5 and 24.9 kg/m2)

You may not qualify if:

• coronary heart disease
• diabetes mellitus
• kidney disease
• liver conditions
• endocrine conditions
• gastrointestinal disorders
• pregnancy
• lactation,
• competitive sports
• alcohol
• drug dependency

Sponsors & Collaborators

• Agricultural University of Athens: lead

Study Sites (1)

Agricultural University of Athens

Athens, 11855, Greece

Location

MeSH Terms

Conditions

Appetitive Behavior

Interventions

Glucose

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Emilia Papakonstantinou, PhD

  Agricultural University of Athens

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Participants were assigned to the interventions using a sequence of random numbers extracted from computer software. A researcher not involved with the collection and the analysis of the scientific data, was responsible for the randomization of the volunteers to the intervention days examining the test foods. All test meals (glucose and honeys) were diluted in 300ml water and were served in dark paper cups covered with a lid in order to achieve double blind conditions.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Primary investigator

Model Details: Eleven healthy participants consumed in random order 50g available carbohydrates as glucose (tested three times) and 50g available carbohydrates as fir, chestnut, healther, thyme, pine, citrus, tested once, on separate occasions

Study Record Dates

• First Submitted: October 31, 2017
• First Posted: November 6, 2017
• Study Start: February 12, 2017
• Primary Completion: April 12, 2017
• Study Completion: September 2, 2017
• Last Updated: November 6, 2017

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)