Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)

NCT03313817 | Completed

• 1 other identifier: ALR_2017_17
• Study Type: observational
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia. Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.

Conditions

Magnetic Resonance Imaging; Diagnosis; Etiology; Prognosis; Retinal Artery Occlusion

Outcome Measures

Primary Outcomes (5)

• Contrast enhancement of the ophthalmic artery

  Binary variable (yes/no)

  Baseline

• Presence of a thrombus

  Binary variable (yes/no)

  Baseline

• Presence of an arterial stenosis of the supra aortic trunks

  Binary variable (yes/no)

  Baseline

• Hypersignal of the ophthalmic artery in diffusion

  Binary variable (yes/no)

  Baseline

• Restriction of the apparent diffusion coefficient (ADC) at the optic nerve level and at the papilla level

  Binary variable (yes/no)

  Baseline

Interventions

Additional MRI sequences DEVICE

Patients will be hospitalized for suspicion of CRAO. An "optimized" MRI will be performed with specific sequences: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; 3D PD T1 after injection. A consultation of ophthalmology and a control MRI will be carried out one month after the CRAO. Again, specific sequences will be added: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; DTI (Diffusion Tensor Imaging); 3D PD T1 after injection.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients hospitalized for CRAO ≤ 48 hours.

You may qualify if:

• years of age or older
• CRAO (onset of symptoms ≤ 48 hours)
• Consent to participate in the study

You may not qualify if:

• \- Contraindications to 3 Tesla MRI

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Ophtalmologique A. de Rothschild

Paris, France

Location

MeSH Terms

Conditions

Retinal Artery Occlusion; Disease

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 25, 2017
• First Posted: October 18, 2017
• Study Start: December 13, 2017
• Primary Completion: October 24, 2023
• Study Completion: January 24, 2024
• Last Updated: January 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)