Perception of Baby's Painful Cry in fMRI

NCT03190486 | Completed

• 2 other identifiers: 1708071ID-RCB
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Crying is the primary signaling strategy available to the human newborn for eliciting parental care. Yet, the investigators only have superficial understanding of the information carried by cries, and how this information is perceived by parents. Using modern tools of sound processing and functional Magnetic Resonance Imaging (fMRI) experiment, this study aims to investigate cry-induced brain activation in adult depending on the cry's acoustic properties expressing various degrees of stress and distress levels. For that, Adults will be tested inside a fMRI magnet to determine their brain activations elicited by different babies cries according to whether the cry was evoked in a pain situation or not. The cerebral activity will be investigated in relation to acoustic features of cries (e.g. with pitch and/or roughness variations). To test if the gender or parentally of adult listeners influence their perceptions and brain responses, the task will be applied to 2 different groups (men and women not-parents). The hypothesis is that the brain of adult listeners will be able to discriminate adequately the intensity of the pain mediated by the cries. This process should involve brain areas such as the insular and the orbito frontal cortex that are known to participate in the integration of pain intensity and pain controls. The experiment should also determine which one of the acoustic features is able to transmit pain and to recruit brain areas involved in pain processes.

Conditions

Magnetic Resonance Imaging; Neuronal Activity

Keywords

Baby cries; pain; brain responses; neuroimaging; fMRI

Outcome Measures

Primary Outcomes (1)

• BOLD (blood-oxygen-level dependent) -contrast imaging

  Measure of blood-oxygen-level dependent with fMRI during listening to natural crying.

  at inclusion

Secondary Outcomes (2)

• BOLD (blood-oxygen-level dependent) -contrast imaging

  at inclusion

• impact of gender and parenting on perception of baby's cry

  at inclusion

Study Arms (4)

Men contact-less with children

EXPERIMENTAL

functional Magnetic Resonance Imaging (fMRI).

Other: functional Magnetic Resonance Imaging (fMRI)

Women contact-less with children

EXPERIMENTAL

functional Magnetic Resonance Imaging (fMRI).

Other: functional Magnetic Resonance Imaging (fMRI)

Father contact-less with children

EXPERIMENTAL

functional Magnetic Resonance Imaging (fMRI).

Other: functional Magnetic Resonance Imaging (fMRI)

Mother contact-less with children

EXPERIMENTAL

functional Magnetic Resonance Imaging (fMRI).

Other: functional Magnetic Resonance Imaging (fMRI)

Interventions

functional Magnetic Resonance Imaging (fMRI) OTHER

During fMRI, healthy volunteers will listen 80 baby's cry.

Also known as: fMRI

Father contact-less with children; Men contact-less with children; Mother contact-less with children; Women contact-less with children

Eligibility Criteria

• Age: 18 Years - 50 Years
• Gender Eligibility Details: 40 women and 40 men
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Man or woman aged between 18 and 50
• Contact-less with children
• right-handed
• Giving their written informed consent
• Subject who agreed to communicate MRI results to their attending physician
• French Social Security affiliation

You may not qualify if:

• any contraindications to pass an fMRI test
• Pregnant woman

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead
• University Hospital of Saint-Etienne: collaborator

Study Sites (1)

Service de Neurologie - CHU de Saint-Etienne

Saint-Etienne, 42055, France

Location

Related Publications (1)

• Fauchon C, Corvin S, Faillenot I, Patural H, Reby D, Peyron R, Mathevon N. Parenting and empathy capabilities drive brain response to pain cues in baby cries. Pain. 2026 Jan 15. doi: 10.1097/j.pain.0000000000003914. Online ahead of print.

  PMID: 41557145 DERIVED

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Roland PEYRON, MD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 20 men and 20 women : group "non parent" 20 father and 20 mother : group "parent"

Study Record Dates

• First Submitted: June 15, 2017
• First Posted: June 16, 2017
• Study Start: July 24, 2017
• Primary Completion: July 5, 2018
• Study Completion: July 5, 2018
• Last Updated: October 10, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)