Intravoxel Incoherent Motion Prognostic Value in the Initial Evaluation of Patients With Acute Ischemic Strokes Using 3 Tesla Magnetic Resonance Imaging

NCT03265860 | Completed

• 1 other identifier: ALR_2017_5
• Study Type: observational
• Target: 274
• Locations: 1 country
• Sites: 1

Brief Summary

Ischemic strokes are the first cause of handicap in adult people, the second cause of dementia and the third cause of death in France. Brain Magnetic Resonance (MR) initial assessment is mandatory to get the right diagnosis, to exclude hemorrhagic lesions and to determine the best treatment. The conventional diffusion weighted imaging sequence is used to establish the diagnosis and to estimate the volume of ischemic lesions. The perfusion weighted imaging sequences are also used to assess the diffusion-perfusion mismatch which is supposed to be the ischemic penumbra corresponding to territories that could be saved with appropriate treatments. IntraVoxel Incoherent Motion (IVIM) is a multi-b diffusion sequence which allows to extract four quantitative variables (D, D\*, f, ADC) related to the true molecular diffusion and correlated to the microvascular perfusion. It's a quick sequence with no need of contrast injection and allowing a perfect coregistration with the true diffusion. It has been validated in many pathologies but not in acute strokes. The feasibility of this sequence in acute ischemic strokes has already been assessed with interesting results. The study aims to assess the correlation between the quantitative values of IVIM at initial MR exam and the modified Rankin Scale (mRS) score 3 months after an acute ischemic stroke.

Conditions

Stroke; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Correlation between quantitative values of IntraVoxel Incoherent Motion at initial Magnetic Resonance Imaging (MRI) and the modified Rankin Scale (mRS) at 3 months after an acute ischemic stroke.

  IntraVoxel Incoherent Motion is a diffusion sequence which allows to extract four quantitative variables (D, D\*, f, ADC) related to the true molecular diffusion and correlated to the microvascular perfusion. We aim to assess the correlation between the quantitative values of IVIM at initial exam and the mRS score 3 months after an acute ischemic stroke.

  3 months

Interventions

IntraVoxel Incoherent Motion sequence DEVICE

The IVIM diffusion sequence with a duration of 2 minutes is added to the imaging protocol.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with an acute ischemic stroke

You may qualify if:

• Adult patients
• Admitted for an acute ischemic stroke
• Affiliated to a Social Security scheme

You may not qualify if:

• Absolute contraindications to MRI
• Pregnant or breastfeeding woman

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Ophtalmologique A. de Rothschild

Paris, France

Location

Related Publications (1)

• Sajust de Bergues de Escalup A, Duron L, Seners P, Sabben C, Obadia M, Yavchitz A, Savatovsky J, Lecler A. Prediction of functional outcome in patients with ischemic stroke using advanced diffusion-weighted MRI parameters at 3 Tesla. Diagn Interv Imaging. 2026 Mar 19:S2211-5684(26)00049-5. doi: 10.1016/j.diii.2026.03.001. Online ahead of print.

  PMID: 41862395 RESULT

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Augustin Lecler, MD

  Fondation Ophtalmologique A. de Rothschild

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 28, 2017
• First Posted: August 29, 2017
• Study Start: August 10, 2017
• Primary Completion: March 14, 2021
• Study Completion: June 14, 2021
• Last Updated: March 25, 2026

Record last verified: 2026-03

Locations

FR (1)