NCT03306056

Brief Summary

The main purpose of this study is to compare the effects of whole-body electromyostimulation versus a conventional low-volume strength-training program, each combined with an individualized, weight-reducing diet, on the cardiometabolic risk profile, muscle strength, body composition, inflammatory markers and subjective health outcomes in overweight individuals at increased cardiometabolic risk.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 27, 2017

Completed
13 days until next milestone

First Posted

Study publicly available on registry

October 10, 2017

Completed
22 days until next milestone

Study Start

First participant enrolled

November 1, 2017

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2020

Completed
Last Updated

October 17, 2018

Status Verified

October 1, 2018

Enrollment Period

2.9 years

First QC Date

September 27, 2017

Last Update Submit

October 15, 2018

Conditions

Keywords

ExerciseStrength TrainingHealth PromotionInflammationBody Composition

Outcome Measures

Primary Outcomes (1)

  • Metabolic Syndrome Z-Score (MetS-Z-Score)

    MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex.

    12 weeks (baseline to 12 week follow-up assessment)

Secondary Outcomes (8)

  • Muscle strength

    12 weeks (baseline to 12 week follow-up assessment)

  • Body Composition

    12 weeks (baseline to 12 week follow-up assessment)

  • Cardiorespiratory Fitness (CRF)

    12 weeks (baseline to 12 week follow-up assessment)

  • Inflammation status

    12 weeks (baseline to 12 week follow-up assessment)

  • Health-related quality of life

    12 weeks (baseline to 12 week follow-up assessment)

  • +3 more secondary outcomes

Study Arms (4)

Control

EXPERIMENTAL

Nutritional therapy / no exercise

Other: Control

Standard Strength Training

EXPERIMENTAL

Nutritional therapy combined with a Standard Strength Training program

Other: Standard Strength Training

Low-volume Strength Training

EXPERIMENTAL

Nutritional therapy combined with a low-volume Strength Training program

Other: Low-volume Strength Training

Whole-body Electromyostimulation

EXPERIMENTAL

Nutritional therapy combined with Whole-Body Electromyostimulation

Other: Whole-Body Electromyostimulation (WB-EMS)

Interventions

ControlOTHER

Individualized, weight-reducing nutritional therapy and counseling, during a study period of 12 weeks

Control

Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with a standard strength training program: * 5 strength training exercises (chest, upper/lower back, abdominals, legs) * 3 sets per exercise * time-effort per session: \~90 min * 2 training sessions per week * duration of exercise intervention: 12 weeks

Standard Strength Training

Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined a low-volume strength training program: * 5 strength training exercises (chest, upper/lower back, abdominals, legs) * 1 set per exercise * time-effort per session: \~20 min * 2 training sessions per week * duration of exercise intervention: 12 weeks

Low-volume Strength Training

Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with WB-EMS: * time-effort per session: \~20 min * duration of exercise intervention: 12 weeks

Whole-body Electromyostimulation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Body Mass Index \>25
  • presence of at least 2 cardiometabolic risk factors

You may not qualify if:

  • Healthy persons or patients under age
  • Overweight persons without any additional cardiometabolic risk factors
  • Pregnancy, Lactation
  • Psychological disorders, epilepsy, sever neurological disorders
  • Participation in other exercise- or nutrition studies within the last 6 months
  • acute cardiovascular disease
  • malignant disease
  • Rheuma
  • Intake of anabolic drugs,
  • Skin injuries in the area of electrode placements
  • Electronic implants (defibrillator, pacemaker)
  • Persons in mental hospitals by order of authorities or jurisdiction

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports,

Erlangen, 91052, Germany

RECRUITING

MeSH Terms

Conditions

OverweightObesityMetabolic SyndromeMotor ActivityInflammation

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsInsulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic DiseasesBehaviorPathologic Processes

Study Officials

  • Dejan Reljic, Dr.

    University Erlangen Nuremberg Medical School

    PRINCIPAL INVESTIGATOR
  • Yurdaguel Zopf, Prof.

    University Erlangen Nuremberg Medical School

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking).
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: parallel-group, randomized-controlled study
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 27, 2017

First Posted

October 10, 2017

Study Start

November 1, 2017

Primary Completion

September 30, 2020

Study Completion

September 30, 2020

Last Updated

October 17, 2018

Record last verified: 2018-10

Locations