The GEOLynch Cohort Study
GEOLynch
4 other identifiers
observational
1,000
1 country
1
Brief Summary
The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2006
CompletedFirst Submitted
Initial submission to the registry
September 14, 2017
CompletedFirst Posted
Study publicly available on registry
October 6, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2030
October 6, 2017
October 1, 2017
24.4 years
September 14, 2017
October 5, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Colorectal tumour diagnoses
All diagnosed colorectal adenomas and carcinomas described in paticipants' medical reports and/or pathology reports.
Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.
Endometrial cancer diagnoses
All diagnosed endometrial cancers described in participants' medical reports and/or pathology reports.
Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.
Overall cancer diagnoses
All diagnosed cancer types described in participants' medical reports and/or pathology reports.
Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.
Study Arms (1)
Persons with Lynch syndrome
Interventions
Eligibility Criteria
Men and women aged 18 to 80 years with Lynch syndrome who do or do not have a (previous) cancer diagnosis.
You may qualify if:
- Persons with a known mutation in a gene that causes Lynch syndrome, i.e. with an inherited monoallelic pathogenic germline mutation in either the MLH1, MSH2, MSH6, PMS2 or EPCAM gene.
You may not qualify if:
- Additional carrier of another hereditary colon cancer predisposition syndrome (e.g. FAP)
- (Chronic) Inflammatory bowel disease
- Non-Dutch speaking
- Dementia or another mental condition that makes it impossible to fill out questionnaires
- Terminally ill persons
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Wageningen Universitylead
- Wereld Kanker Onderzoek Fondscollaborator
- Dutch Cancer Societycollaborator
- Funding: Biobanking and BioMolecular resources Research Infrastructure The Netherlandscollaborator
Study Sites (1)
Wageningen University
Wageningen, Netherlands
Related Publications (6)
van Duijnhoven FJ, Botma A, Winkels R, Nagengast FM, Vasen HF, Kampman E. Do lifestyle factors influence colorectal cancer risk in Lynch syndrome? Fam Cancer. 2013 Jun;12(2):285-93. doi: 10.1007/s10689-013-9645-8.
PMID: 23657759BACKGROUNDJung AY, van Duijnhoven FJ, Nagengast FM, Botma A, Heine-Broring RC, Kleibeuker JH, Vasen HF, Harryvan JL, Winkels RM, Kampman E. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study. Cancer Causes Control. 2014 Sep;25(9):1119-29. doi: 10.1007/s10552-014-0412-4. Epub 2014 Jun 12.
PMID: 24916333RESULTBotma A, Nagengast FM, Braem MG, Hendriks JC, Kleibeuker JH, Vasen HF, Kampman E. Body mass index increases risk of colorectal adenomas in men with Lynch syndrome: the GEOLynch cohort study. J Clin Oncol. 2010 Oct 1;28(28):4346-53. doi: 10.1200/JCO.2010.28.0453. Epub 2010 Aug 23.
PMID: 20733131RESULTWinkels RM, Botma A, Van Duijnhoven FJ, Nagengast FM, Kleibeuker JH, Vasen HF, Kampman E. Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome. Gastroenterology. 2012 Feb;142(2):241-7. doi: 10.1053/j.gastro.2011.10.033. Epub 2011 Nov 4.
PMID: 22062356RESULTBotma A, Vasen HF, van Duijnhoven FJ, Kleibeuker JH, Nagengast FM, Kampman E. Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study. Cancer. 2013 Feb 1;119(3):512-21. doi: 10.1002/cncr.27726. Epub 2012 Dec 17.
PMID: 23254892RESULTHeine-Broring RC, Winkels RM, Botma A, van Duijnhoven FJ, Jung AY, Kleibeuker JH, Nagengast FM, Vasen HF, Kampman E. Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study. PLoS One. 2013 Jun 18;8(6):e66819. doi: 10.1371/journal.pone.0066819. Print 2013.
PMID: 23825568RESULT
Related Links
Biospecimen
Buccal swabs and blood samples.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ellen Kampman, PhD
Wageningen University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 14, 2017
First Posted
October 6, 2017
Study Start
July 1, 2006
Primary Completion (Estimated)
December 1, 2030
Study Completion (Estimated)
December 1, 2030
Last Updated
October 6, 2017
Record last verified: 2017-10