Family Research Study: Metabolism of Fats and Proteins in Specific Ethnic Groups

NCT00853775 | Completed DMC

• 2 other identifiers: 2008165332R01HL062705-05A2
• Study Type: observational
• Target: 325
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease. The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.

Conditions

Healthy; Heart Disease

Keywords

heart disease; cardiovascular disease; lipoproteins; lipoprotein(a); Lp(a); apolipoprotein(a); apo(a); fats; proteins; metabolism

Outcome Measures

Primary Outcomes (1)

• Genetic variation of Lp(a) levels in each group

  five years

Study Arms (2)

African American Families

Families with 2 parents and 2 children - no intervention, observational study

Other: No intervention, observational study

Caucasian Families

Families with 2 parents and 2 children - no intervention, observational study

Other: No intervention, observational study

Interventions

No intervention, observational study OTHER

African American Families; Caucasian Families

Eligibility Criteria

• Age: 6 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We are recruiting 100 African American and 100 Caucasian families. The families that will be recruited will have two natural parents and two natural offspring.

You may qualify if:

• Of Caucasian or African descent
• Families must have 2 natural/biological parents and 2 natural/biological offspring
• years old or older

You may not qualify if:

• Races other than African American or Caucasian
• Families without 2 natural/biological parents and 2 natural/biological offspring
• younger that 6 years old

Sponsors & Collaborators

• University of California, Davis: lead
• National Institutes of Health (NIH): collaborator
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

UC Davis CTSC Clinical Research Center (CCRC) at Veterans Affair Medical Center

Mather, California, 95655, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

plasma, DNA, white blood cell

MeSH Terms

Conditions

Heart Diseases; Cardiovascular Diseases

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Lars Berglund, M.D., Ph.D.

  University of California, Davis

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 25, 2009
• First Posted: March 2, 2009
• Study Start: February 1, 2009
• Primary Completion: May 1, 2012
• Study Completion: December 1, 2012
• Last Updated: May 30, 2017

Record last verified: 2017-05

Locations

US (1)