Improving Muscle Strength, Mass and Physical Function in Older Adults

NCT03297632 | Unknown

• 1 other identifier: VCC-LIFE-3
• Study Type: interventional
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Falls and fractures are serious and costly events for elderly individuals: they cause functional impairments, increase mortality and contribute to huge healthcare costs for the society. The number of falls, and following consequences, are expected to increase in society as the proportion of the elderly population will increase, therefore it is crucial to be able to detect and prevent falls and fractures in the population. The investigators have previously published results that objective measurements of postural balance can predict fall risk in 70-year-olds in Umeå and subsequently investigated whether balance can be improved through 4-week balance exercise program. However, preliminary results suggest that the frequency and duration of exercise should be longer than 3 times a week for 4 weeks to produce effects. Furthermore, there is also evidence indicating a link between muscle weakness and fall risk in elderly subjects, while research findings show that it is possible for older individuals to influence muscle strength and muscle mass with resistance exercise. Functional strength training can also positively influence the balance. In this context, the investigators aim to investigate whether a 10-week resistance exercise program may positively affect balance, muscle strength, muscle mass and physical function, with the aim of preventing future falls and fractures in the population.

Conditions

Muscle Weakness; Fall; Sarcopenia

Outcome Measures

Primary Outcomes (3)

• Change in Postural Stability performance

  Postural stability measurement task from the Short Physical Performance Battery (SPPB), containing bipedal, semi-tandem and tandem stances. Measured in seconds, up to a maximal value of 10 seconds.

  Change in Postural Stability performance at 10 and 34 weeks

• Change in Gait Speed

  Gait speed measurement task from the Short Physical Performance Battery (SPPB). Measured in the seconds it takes to walk 4 meters.

  Change in Gait Speed at 10 and 34 weeks

• Change in Chair Stand performance

  Chair stand measurement task from the Short Physical Performance Battery (SPPB). Measures in the time it takes to stand up 5 times.

  Change in Chair stand performance at 10 and 34 weeks

Secondary Outcomes (7)

• Change in Postural Sway

  Change in Baseline Postural Sway at 10 and 34 weeks

• Change in Isometric Muscle Strength

  Change in Baseline Isometric Muscle Strength at 10 and 34 weeks

• Change in Appendicular Muscle Mass

  Change in Baseline Appendicular Muscle Mass at 10 and 34 weeks

• Change in TUG test performance

  Change in Baseline TUG test performance at 10 and 34 weeks

• Change in Physical Activity

  Change in Baseline Physical Activity at 10 and 34 weeks

Study Arms (3)

Intervention Group

EXPERIMENTAL

Receives instructor-based functional resistance exercise. 45 minutes per session. 3 times per week, during 10 weeks in total.

Behavioral: Functional resistance exercise

Control group

NO INTERVENTION

Asked to normally active according to their current lifestyle

Home-based group

ACTIVE COMPARATOR

Receives home-based exercises with written instructions and digital video support. 45 minutes per session. 3 times per week, during 10 weeks in total.

Behavioral: Functional resistance exercise

Interventions

Functional resistance exercise BEHAVIORAL

Functional resistance program designed for older individuals with low muscle mass and muscle strength. The goal is to implement exercises that are possible for the participants to also perform in their home environment, through the use of basic equipment.

Home-based group; Intervention Group

Eligibility Criteria

• Age: 70 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Participation in the Healthy Ageing Initiative (HAI) study
• Appendicular lean mass index in the lowest 20% measured with the iDXA in the HAI study, separate for men and women.

You may not qualify if:

• Unable to be present during all 10 weeks of exercise.

Sponsors & Collaborators

• Region Västerbotten: lead

Study Sites (1)

Livsmedicin (LIFE)

Umeå, Västerbotten County, 907 36, Sweden

Location

Related Publications (23)

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• Borde R, Hortobagyi T, Granacher U. Dose-Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis. Sports Med. 2015 Dec;45(12):1693-720. doi: 10.1007/s40279-015-0385-9.

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• Yu W, An C, Kang H. Effects of Resistance Exercise Using Thera-band on Balance of Elderly Adults: A Randomized Controlled Trial. J Phys Ther Sci. 2013 Nov;25(11):1471-3. doi: 10.1589/jpts.25.1471. Epub 2013 Dec 11.

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  PMID: 24387140 BACKGROUND

• LIFE Study Investigators; Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65. doi: 10.1093/gerona/61.11.1157.

  PMID: 17167156 BACKGROUND

• Vikberg S, Sorlen N, Branden L, Johansson J, Nordstrom A, Hult A, Nordstrom P. Effects of Resistance Training on Functional Strength and Muscle Mass in 70-Year-Old Individuals With Pre-sarcopenia: A Randomized Controlled Trial. J Am Med Dir Assoc. 2019 Jan;20(1):28-34. doi: 10.1016/j.jamda.2018.09.011. Epub 2018 Nov 7.

  PMID: 30414822 DERIVED

MeSH Terms

Conditions

Muscle Weakness; Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Muscular Atrophy; Atrophy; Pathological Conditions, Anatomical

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Adjunct Professor

Study Record Dates

• First Submitted: September 18, 2017
• First Posted: September 29, 2017
• Study Start: September 4, 2017
• Primary Completion: November 30, 2019
• Study Completion: November 30, 2019
• Last Updated: October 26, 2018

Record last verified: 2018-10

Locations

SE (1)