Effects of Eccentric Training Intervention in Older Adults

NCT04099316 | Unknown DMC

• 1 other identifier: B-1705-397-004
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

Sarcopenia leads to loss of muscle mass and muscle strength during the aging process. It has been reported that eccentric training has some positive effects on the preservation of eccentric strength, with less delayed onset muscle soreness (DOMS) in older groups, and lower metabolic costs.

Conditions

Sarcopenia

Keywords

Aging; Eccentric training; Muscle strength; Physical function; Sarcopenia

Outcome Measures

Primary Outcomes (3)

• Gait speed

  An examiner used a stopwatch to time how long it took subjects to walk along a marked tape. The Kinect device was used to measure gait speed.

  Change from baseline gaitspeed at 8 weeks

• Stair climb

  Subjects were measured on eight 17-cm stairs twice, requiring a step by step pattern, where the timer activated when the first contact was made at the first step and ended when the contact occurred at the last step before and after the 8 weeks of exercise training.

  Change from baseline stair climb at 8 weeks

• Chair stand

  Subjects had to get up from a chair measuring 41 cm in height with a flat seat. Subjects were asked to stand up and sit down 5 times as quickly as possible with their arms folded across the chest. They stood up until full extension was observed at the trunk and lower limb joints, and returned to a seated position with their back fully supported at the back of the chair.

  Change from baseline chair stand at 8 weeks

Secondary Outcomes (3)

• Isokinetic knee strength

  Change from baseline isokinetic knee strength at 8 weeks

• Isometric knee strength

  Change from baseline isometric knee strength at 8 weeks

• Power

  Change from baseline power at 8 weeks

Study Arms (3)

Older adults

EXPERIMENTAL

Older adults (Over the 60 years), Subjects did not suffer from musculoskeletal or metabolic diseases.

Device: Eccentric exercise

Older adults-Control

EXPERIMENTAL

Older adults (Over the 60 years), Subjects did not suffer from musculoskeletal or metabolic diseases.

Device: Conventional resistance exercise

No intervention

NO INTERVENTION

Metabolic diseases, Hypertension (150/90mmHg), Myocardial infarction within 6 months. Fractures within 6 months.

Interventions

Eccentric exercise DEVICE

Eccentric exercise with Eccentron electronic device. Exercise intervention: The exercise intervention is performed to twice a week (Total 8 weeks). Exercise intensity is gradually increased to the number of times by divided into two stages (1-4 weeks; 1st stage),(5-8 weeks; 2nd stage).

Older adults

Conventional resistance exercise DEVICE

Leg press exercise with leg press machine. Exercise intervention: The exercise intervention is performed to twice a week (total 8 weeks). Exercise intensity is gradually increased to the number of times by divided into two stages (1-4 weeks; 1st stage), (5-8 weeks; 2nd stage).

Older adults-Control

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects who can agree voluntarily
• Older men/women: Age (60 - 80 yrs)

You may not qualify if:

• Uncontrolled hypertension
• Acute coronary syndrome
• Subjects who took drugs which can affects neuromuscular system
• Subjects who cannot agree voluntarily

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead
• National Research Foundation of Korea: collaborator

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam, Geyonggi, 463-707, South Korea

RECRUITING

Related Publications (17)

• Roig M, Macintyre DL, Eng JJ, Narici MV, Maganaris CN, Reid WD. Preservation of eccentric strength in older adults: Evidence, mechanisms and implications for training and rehabilitation. Exp Gerontol. 2010 Jun;45(6):400-9. doi: 10.1016/j.exger.2010.03.008. Epub 2010 Mar 18.

  PMID: 20303404 BACKGROUND

• Frontera WR, Hughes VA, Krivickas LS, Roubenoff R. Contractile properties of aging skeletal muscle. Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S16-20. doi: 10.1123/ijsnem.11.s1.s16. No abstract available.

  PMID: 11915915 BACKGROUND

• Frontera WR, Reid KF, Phillips EM, Krivickas LS, Hughes VA, Roubenoff R, Fielding RA. Muscle fiber size and function in elderly humans: a longitudinal study. J Appl Physiol (1985). 2008 Aug;105(2):637-42. doi: 10.1152/japplphysiol.90332.2008. Epub 2008 Jun 12.

  PMID: 18556434 BACKGROUND

• Cadore EL, Rodriguez-Manas L, Sinclair A, Izquierdo M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuvenation Res. 2013 Apr;16(2):105-14. doi: 10.1089/rej.2012.1397.

  PMID: 23327448 BACKGROUND

• Chen TC, Tseng WC, Huang GL, Chen HL, Tseng KW, Nosaka K. Superior Effects of Eccentric to Concentric Knee Extensor Resistance Training on Physical Fitness, Insulin Sensitivity and Lipid Profiles of Elderly Men. Front Physiol. 2017 Apr 10;8:209. doi: 10.3389/fphys.2017.00209. eCollection 2017.

  PMID: 28443029 BACKGROUND

• Dias CP, Toscan R, de Camargo M, Pereira EP, Griebler N, Baroni BM, Tiggemann CL. Effects of eccentric-focused and conventional resistance training on strength and functional capacity of older adults. Age (Dordr). 2015 Oct;37(5):99. doi: 10.1007/s11357-015-9838-1. Epub 2015 Sep 15.

  PMID: 26374635 BACKGROUND

• Enoka RM. Eccentric contractions require unique activation strategies by the nervous system. J Appl Physiol (1985). 1996 Dec;81(6):2339-46. doi: 10.1152/jappl.1996.81.6.2339.

  PMID: 9018476 BACKGROUND

• Gault ML, Willems ME. Aging, functional capacity and eccentric exercise training. Aging Dis. 2013 Sep 25;4(6):351-63. doi: 10.14336/AD.2013.0400351.

  PMID: 24307968 BACKGROUND

• Hanson ED, Srivatsan SR, Agrawal S, Menon KS, Delmonico MJ, Wang MQ, Hurley BF. Effects of strength training on physical function: influence of power, strength, and body composition. J Strength Cond Res. 2009 Dec;23(9):2627-37. doi: 10.1519/JSC.0b013e3181b2297b.

  PMID: 19910811 BACKGROUND

• LaStayo P, Marcus R, Dibble L, Wong B, Pepper G. Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program. BMC Geriatr. 2017 Jul 17;17(1):149. doi: 10.1186/s12877-017-0539-8.

  PMID: 28716003 BACKGROUND

• Lim JY. Therapeutic potential of eccentric exercises for age-related muscle atrophy. Integr Med Res. 2016 Sep;5(3):176-181. doi: 10.1016/j.imr.2016.06.003. Epub 2016 Jun 18.

  PMID: 28462115 BACKGROUND

• Mueller M, Breil FA, Vogt M, Steiner R, Lippuner K, Popp A, Klossner S, Hoppeler H, Dapp C. Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol. 2009 Sep;107(2):145-53. doi: 10.1007/s00421-009-1108-4. Epub 2009 Jun 20.

  PMID: 19543908 BACKGROUND

• Orer GE, Guzel NA, Arslan E. Recovery levels after eccentric and concentric loading in maximal force. J Phys Ther Sci. 2016 Jun;28(6):1743-7. doi: 10.1589/jpts.28.1743. Epub 2016 Jun 28.

  PMID: 27390407 BACKGROUND

• Raj IS, Bird SR, Westfold BA, Shield AJ. Effects of eccentrically biased versus conventional weight training in older adults. Med Sci Sports Exerc. 2012 Jun;44(6):1167-76. doi: 10.1249/MSS.0b013e3182442ecd.

  PMID: 22143107 BACKGROUND

• Roig M, O'Brien K, Kirk G, Murray R, McKinnon P, Shadgan B, Reid WD. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. 2009 Aug;43(8):556-68. doi: 10.1136/bjsm.2008.051417. Epub 2008 Nov 3.

  PMID: 18981046 BACKGROUND

• Symons TB, Vandervoort AA, Rice CL, Overend TJ, Marsh GD. Effects of maximal isometric and isokinetic resistance training on strength and functional mobility in older adults. J Gerontol A Biol Sci Med Sci. 2005 Jun;60(6):777-81. doi: 10.1093/gerona/60.6.777.

  PMID: 15983182 BACKGROUND

• Vaczi M, Nagy SA, Koszegi T, Ambrus M, Bogner P, Perlaki G, Orsi G, Toth K, Hortobagyi T. Mechanical, hormonal, and hypertrophic adaptations to 10 weeks of eccentric and stretch-shortening cycle exercise training in old males. Exp Gerontol. 2014 Oct;58:69-77. doi: 10.1016/j.exger.2014.07.013. Epub 2014 Jul 23.

  PMID: 25064038 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Central Study Contacts

Jae-Young Lim, Ph.D.

CONTACT

+821053900373; drlim1@snu.ac.kr

Dae Young Kim, M.S.

CONTACT

821037570435; day22311@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Department of Rehabilitation Medicine

Study Record Dates

• First Submitted: May 16, 2019
• First Posted: September 23, 2019
• Study Start: July 20, 2017
• Primary Completion: September 30, 2019
• Study Completion: October 31, 2019
• Last Updated: September 23, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)