Protein Supplementation and Recovery of Muscle Function

NCT03297151 | Completed DMC

• 2 other identifiers: FHIHAPN3.3RXTC20130001
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The focus is performance nutrition. Resistance exercise can induce low level muscle damage in conjunction with impaired contractile function. Milk-derived proteins contain, or induce, bioactive properties that assist muscle recovery and restore/improve muscle function. The aim of the research is the recovery of muscle function following resistance exercise. In this study, the investigators propose to undertake a comparison of the ingestion of two milk-derived protein-based recovery drinks on muscle function after resistance exercise compares to an isonitrogenous, non-essential amino acid control.

Conditions

Resistance Training; Muscle Damage

Keywords

Resistance Training; Muscle Function; Protein Synthesis

Outcome Measures

Primary Outcomes (1)

• Change in Muscle Contractile Function

  Maximal Voluntary Contract (MVC) of Knee Extensor Muscle measured by laboratory-based ergometry

  Day 9, 10, 11, 12, 13, 14, 15, 16 and 17

Secondary Outcomes (1)

• Change in Muscle Protein Synthesis

  Day 11 and 16

Study Arms (3)

CONTROL

SHAM COMPARATOR

Intervention: Dietary Supplement: Non-essential amino acids A group of subjects ingesting a liquid beverage (per kilogram body mass: 0.33g non-essential amino acids dissolved in water ) prior to completion of a prescribed resistance exercise training (RET) session. Muscle Contractile Function to be conducted prior to and following the RET session by laboratory-based ergometry. Muscle Protein Synthesis induced by RET to be measured by deuterium incorporation in to skeletal muscle sampled by microbiopsy.

Dietary Supplement: CONTROL

PROTEIN

ACTIVE COMPARATOR

Intervention: Dietary Supplement: Whey Protein Concentrate A group of subjects ingesting a liquid beverage (per kilogram body mass: 0.33g of Whey Protein Concentrate dissolved in water ) prior to completion of a prescribed resistance exercise training (RET) session. Muscle Contractile Function to be conducted prior to and following the RET session by laboratory-based ergometry. Muscle Protein Synthesis induced by RET to be measured by deuterium incorporation in to skeletal muscle sampled by microbiopsy.

Dietary Supplement: Whey Protein Concentrate

HYDROLYSATE

ACTIVE COMPARATOR

Intervention: Dietary Supplement: Whey Protein Hydrolysate A group of subjects ingesting a liquid beverage (per kilogram body mass: 0.33g of Whey Protein Hydrolysate dissolved in water ) prior to completion of a prescribed resistance exercise training (RET) session. Muscle Contractile Function to be conducted prior to and following the RET session by laboratory-based ergometry. Muscle Protein Synthesis induced by RET to be measured by deuterium incorporation in to skeletal muscle sampled by microbiopsy.

Dietary Supplement: Whey Protein Hydrolysate

Interventions

CONTROL DIETARY_SUPPLEMENT

Food grade mixture of non-essential amino acids in powdered form, flavoured and instantised to be dissolved in water. Supplied by Carbery Food Ingredients Limited, Ballineen, Ireland. Product Reference Number 10955

CONTROL

Whey Protein Concentrate DIETARY_SUPPLEMENT

Whey protein concentrate in powdered form, flavoured and instantised to be dissolved in water. Supplied by Carbery Food Ingredients Limited, Ballineen, Ireland. Trade name of product is Carbelac80 Instant Product Reference Number 10431

Also known as: Carbelac80 Instant

PROTEIN

Whey Protein Hydrolysate DIETARY_SUPPLEMENT

Whey protein concentrate hydrolysate (degree of hydrolysate 27%) in powdered form, flavoured and instantised to be dissolved in water. Supplied by Carbery Food Ingredients Limited, Ballineen, Ireland. Product Reference Number 10468

HYDROLYSATE

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• risk
• no known current illness or physically active
• resistance-exercise trained
• no known intolerance to milk-based products
• no known blood born disease or medication that would adversely affect participation
• no adverse risk to venepuncture

You may not qualify if:

• recent musculoskeletal injury

Sponsors & Collaborators

• University of Limerick: lead

Study Sites (1)

University of Limerick

Limerick, Co Limerick, Ireland

Location

Related Links

• Food For Health Ireland National Technology Centre

MeSH Terms

Interventions

Whey

Intervention Hierarchy (Ancestors)

Milk; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages

Study Officials

• Philip M Jakeman, PhD

  University of Limerick

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Double blind (participant and investigator)
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Block randomised, between group study

Study Record Dates

• First Submitted: August 17, 2017
• First Posted: September 29, 2017
• Study Start: July 1, 2017
• Primary Completion: September 30, 2017
• Study Completion: March 20, 2021
• Last Updated: January 31, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

IE (1)