The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Recovery Following Strenuous Exercise

NCT05010057 | Completed

• 1 other identifier: UEC/2015/112/FHMS
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise. The investigation will compare responses between an experimental (NZBC capsule, 300 mg/day) and placebo (PLA capsule, 300 mg sugar) group. Participants will attend a screening session where they will consent to the study, complete a pre-activity medical questionnaire and have their height, weight and resting blood pressure measured. If the participants meet the inclusion criteria they will perform a familarisation session on the muscle strength assessment. Participants will be randomized to NZBC or placebo groups, and consume one capsule in the morning (between 6-10 am) for 12 days. This is a double-blinded study, which means that the participant and the study team will not know which group the participants are assigned to until the study is over. On day 8 participants will perform a strenuous bout of upper body resistance exercise on the isokinetic dynamometer (exercise device). Muscle strength and soreness, arm circumference, and elbow range of motion will be measured, and a fasted blood sample will be collected, before and 24, 48, 72 \& 96 hours after the muscle fatigue protocol (on days 9, 10, 11 \& 12). A marker of muscle damage (creatine kinase \[CK\] concentration) will be measured in the blood samples. Participants will also be asked to complete a 6-day dietary record, beginning on day 7 and ending on the final day of testing (day 12).

Conditions

Muscle Damage

Keywords

Exercise-induced muscle damage; Recovery; Supplementation; Oxidative stress; Anthocyanin; New Zealand blackcurrant

Outcome Measures

Primary Outcomes (2)

• Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise

  Serum biomarker for muscle damage

  At baseline (pre-exercise) and 72 hours post-exercise.

• Change from baseline in creatine kinase (CK) concentration at 96 hours post-exercise

  Serum biomarker for muscle damage

  At baseline (pre-exercise) and 96 hours post-exercise..

Secondary Outcomes (4)

• Change in maximum voluntary contraction (MVC) from baseline to 96 hours post-exercise

  At baseline (pre-exercise) and post-exercise time points (at 0, 24, 48, 72 and 96 hours respectively).

• Change in rating of Delayed Onset of Muscle Soreness (DOMS) from baseline to 96 hours post-exercise

  At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).

• Change in joint range of motion (ROM) from baseline to 96 hours post-exercise

  At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).

• Change in mid arm circumference (MAC) from baseline to 96 hours post-exercise

  At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).

Study Arms (2)

New Zealand blackcurrants (NZBC)

EXPERIMENTAL

1 NZBC capsule (containing 300 mg active cassis containing 105 mg of anthocyanins, i.e. 35-50 % delphinidin-3-rutinoside, 5-20 % delphinidin-3-glucoside, 30-45 % cyanidin-3-rutinoside, 3-10 % cyanidin-3-glucoside), consumed in the morning, for 12 days.

Dietary Supplement: New Zealand blackcurrants (NZBC)

Placebo (PLA)

PLACEBO COMPARATOR

1 placebo capsule (containing 300 mg microcrystalline cellulose M102), consumed in the morning, for 12 days.

Dietary Supplement: Placebo (PLA)

Interventions

New Zealand blackcurrants (NZBC) DIETARY_SUPPLEMENT

NZBC capsules containing anthocyanin-rich blackcurrant extract

Also known as: NZBC extract supplement (Health Currancy Ltd [UK] / CurraNZ Ltd [NZ])

New Zealand blackcurrants (NZBC)

Placebo (PLA) DIETARY_SUPPLEMENT

Placebo capsules containing microcrystalline cellulose

Also known as: Placebo capsules

Placebo (PLA)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males and Females
• years old
• BMI: 19 - 29.9 kg/m2
• Healthy: no active disease process that could interfere with endpoints measured as determined by medical history

You may not qualify if:

• Smoking and tobacco use
• Takes medication \[excluding contraception\]
• BMI ≥ 30 kg/m2
• Hypertensive (diastolic \> 90 and/or systolic blood pressure \> 140 mmHg)
• History of musculoskeletal upper limb injuries
• Performs regular resistance exercise (\> 2 sessions per week)
• Uses dietary supplements that could influence muscle recovery or function (e.g. protein supplements, antioxidants etc)

Sponsors & Collaborators

• University of Surrey: lead

Study Sites (1)

Surrey Human Performance Institute

Guildford, Surrey, GU2 7AD, United Kingdom

Location

Study Officials

• Julie EA Hunt, PhD

  University of Surrey

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Coded, capsules
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomised, parallel design.

Study Record Dates

• First Submitted: August 6, 2021
• First Posted: August 18, 2021
• Study Start: June 10, 2016
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: August 18, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)