Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder

NCT03295838 | Completed

• 1 other identifier: DNR 2011/1909-31/3
• Study Type: interventional
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

The effects of a psychological treatment, Mentalization-Based Treatment, was studied using a research protocol with patients with mood swings and impulsive behavior (borderline personality disorder).

Conditions

Borderline Personality Disorder

Keywords

Borderline personality disorder; Psychotherapy; Treatment outcome; Pragmatic clinical trials as topic; Mentalization-based treatment; Alexithymia

Outcome Measures

Primary Outcomes (1)

• Borderline Symptoms

  Key psychiatric and borderline symptomatology as measured by the Karolinska Borderline And Symptoms Scales (KABOSS-S) was the primary outcome measure. The KABOSS-S consists of three general symptom scales (depression, anxiety, obsessive-compulsive symptoms) derived from the Comprehensive Psychopathological Self-rating Scale for Affective Syndromes and one specific borderline scale compromising the items "Mood swings", "Ability to understand own emotions", "Self-control", "Self-soothing", "Feelings of abandonment", "Feelings of emptiness", "Self-image" and "Reality Presence". Each item is scored on a Likert scale from 0 ("no presence") to 6 ("severe").

  0-18 months

Secondary Outcomes (5)

• Suicidality

  0-18 months

• General Psychiatric Symptoms

  0-18 months

• Self-harm

  0-18 months

• Alexithymia

  0-18 months

• Self-image

  0-18 months

Study Arms (1)

Mentalization-based Treatment

EXPERIMENTAL

MBT was conducted according to the treatment manual developed by Bateman \& Fonagy. Patients were offered individual sessions with a psychotherapist and group sessions with 6-8 participants and 1-2 group therapists for 18 months. An introductory psycho-educational component (9-12 sessions) was also offered focusing on explicit mentalising skills (i.e. understanding one's own or others' intentions). Group and individual MBT focused on implicit mentalising towards self and others.

Behavioral: Mentalization-based treatment

Interventions

Mentalization-based treatment BEHAVIORAL

See Arm description

Mentalization-based Treatment

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Self-identification.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Karolinska Institutet: lead

Related Publications (1)

• Lof J, Clinton D, Kaldo V, Ryden G. Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. BMC Psychiatry. 2018 Jun 11;18(1):185. doi: 10.1186/s12888-018-1699-6.

  PMID: 29890960 DERIVED

MeSH Terms

Conditions

Borderline Personality Disorder; Affective Symptoms

Interventions

Mentalization-Based Therapy

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Viktor Kaldo, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Med PhD, clinical psychologist, associate professor, research team leader

Model Details: Patients were selected using a research protocol with defined criteria, all patients that were intended to treat in the Mentalization-based Treatment program were followed over 18 months and assessed for primary and secondary outcomes.

Study Record Dates

• First Submitted: September 14, 2017
• First Posted: September 28, 2017
• Study Start: February 1, 2007
• Primary Completion: May 3, 2014
• Study Completion: May 3, 2014
• Last Updated: September 28, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF, ANALYTIC CODE
• Time Frame: 1st feb 2007 - 3rd may 2014.
• Access Criteria: Upon reasonable request.