NCT00358969

Brief Summary

This study is designed to investigate whether guanfacine (Tenex) is an effective treatment for borderline personality disorder (BPD), an illness often characterized by unstable mood and impulsive aggression. Guanfacine stimulates activity in the front portion of the brain, a region associated with attention and the control of behavior. We believe that guanfacine may improve symptoms of BPD by improving attention and aiding regulation of behavior.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2006

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 31, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 1, 2006

Completed
Last Updated

August 1, 2006

Status Verified

July 1, 2006

First QC Date

July 31, 2006

Last Update Submit

July 31, 2006

Conditions

Borderline Personality Disorder

Keywords

borderline personality disorderguanfacineimpulsivityaggressionaffective instability

Outcome Measures

Primary Outcomes (4)

  • measures of impulsive aggression

  • measures of affective disturbance

  • measures of social and occupational functioning

  • measures of overall clinical status

Interventions

guanfacine (Tenex)DRUG

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mount Sinai Hospital - Mood & Personality Research Group

New York, New York, 10029, United States

RECRUITING

MeSH Terms

Conditions

Borderline Personality DisorderImpulsive BehaviorAggression

Interventions

Guanfacine

Condition Hierarchy (Ancestors)

Personality DisordersMental DisordersBehaviorAberrant Motor Behavior in DementiaBehavioral SymptomsSocial Behavior

Intervention Hierarchy (Ancestors)

GuanidinesAmidinesOrganic ChemicalsPhenylacetatesAcids, CarbocyclicCarboxylic Acids

Study Officials

  • Antonia S. New, M.D.

    Icahn School of Medicine at Mount Sinai

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Emily Hart

CONTACT

(212) 241-4459mpgroup@mssm.edu

David Meyerson

CONTACT

(212) 241-9734david.meyerson@mssm.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 31, 2006

First Posted

August 1, 2006

Study Start

July 1, 2006

Last Updated

August 1, 2006

Record last verified: 2006-07

Locations

US(1)