Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder

NCT01896024 | Completed

• 1 other identifier: SNSF 100014-134562
• Study Type: interventional
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder. The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson \& Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post. The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.

Conditions

Borderline Personality Disorder

Outcome Measures

Primary Outcomes (1)

• Outcome Questionnaire -45.2 (Lambert et al., 2004)

  pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months

  3 months

Secondary Outcomes (1)

• Inventory of Interpersonal Problems (Horowitz et al., 1988)

  3 months

Other Outcomes (1)

• Borderline Symptom List (Bohus, 2009)

  3 months

Study Arms (2)

General Psychiatric Management (GPM; Gunderson & Links, 2008)

ACTIVE COMPARATOR

psychodynamic-psychiatric treatment for borderline personality disorder

Behavioral: Psychiatric Management

GPM plus Motive-Oriented Therapeutic Relationship

EXPERIMENTAL

use of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM

Behavioral: Psychiatric Management; Behavioral: Motive-oriented therapeutic relationship/Plan Analysis

Interventions

Psychiatric Management BEHAVIORAL

GPM plus Motive-Oriented Therapeutic Relationship; General Psychiatric Management (GPM; Gunderson & Links, 2008)

Motive-oriented therapeutic relationship/Plan Analysis BEHAVIORAL

GPM plus Motive-Oriented Therapeutic Relationship

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• DSM-IV Borderline Personality Disorder;
• between 18 and 65 yrs of age

You may not qualify if:

• DSM-IV psychotic disorders,
• mental retardation,
• substance abuse in the forefront

Sponsors & Collaborators

• University of Lausanne Hospitals: lead

Study Sites (1)

Department of Psychiatry-CHUV, University of Lausanne

Lausanne, Canton of Vaud, 1004, Switzerland

Location

Related Publications (6)

• Kramer U, Berger T, Kolly S, Marquet P, Preisig M, de Roten Y, Despland JN, Caspar F. Effects of motive-oriented therapeutic relationship in early-phase treatment of borderline personality disorder: a pilot study of a randomized trial. J Nerv Ment Dis. 2011 Apr;199(4):244-50. doi: 10.1097/NMD.0b013e3182125d19.

  PMID: 21451348 RESULT

• Kramer U, Kolly S, Berthoud L, Keller S, Preisig M, Caspar F, Berger T, de Roten Y, Marquet P, Despland JN. Effects of motive-oriented therapeutic relationship in a ten-session general psychiatric treatment of borderline personality disorder: a randomized controlled trial. Psychother Psychosom. 2014;83(3):176-86. doi: 10.1159/000358528. Epub 2014 Apr 17.

  PMID: 24752034 RESULT

• Kramer U, Fluckiger C, Kolly S, Caspar F, Marquet P, Despland JN, de Roten Y. Unpacking the effects of therapist responsiveness in borderline personality disorder: motive-oriented therapeutic relationship, patient in-session experience, and the therapeutic alliance. Psychother Psychosom. 2014;83(6):386-7. doi: 10.1159/000365400. Epub 2014 Oct 16. No abstract available.

  PMID: 25324025 RESULT

• Sallin L, Geissbuehler I, Grandjean L, Beuchat H, Martin-Soelch C, Pascual-Leone A, Kramer U. Self-Contempt, the Working Alliance and Outcome in Treatments for Borderline Personality Disorder: An Exploratory Study. Psychother Res. 2021 Jul;31(6):765-777. doi: 10.1080/10503307.2020.1849848. Epub 2020 Nov 30.

  PMID: 33256540 DERIVED

• Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.

  PMID: 32368793 DERIVED

• Penzenstadler L, Kolly S, Rothen S, Khazaal Y, Kramer U. Effects of substance use disorder on treatment process and outcome in a ten-session psychiatric treatment for borderline personality disorder. Subst Abuse Treat Prev Policy. 2018 Feb 26;13(1):10. doi: 10.1186/s13011-018-0145-6.

  PMID: 29482597 DERIVED

MeSH Terms

Conditions

Borderline Personality Disorder

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: July 5, 2013
• First Posted: July 11, 2013
• Study Start: June 1, 2010
• Primary Completion: May 1, 2013
• Study Completion: April 1, 2014
• Last Updated: December 2, 2014

Record last verified: 2014-12

Locations

CH (1)