The Effect of Non Invasive Brain Stimulation on Impulsivity in Borderline Personality Disorder

NCT05453032 | Completed

• 1 other identifier: 2021-2308
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

A pilot study to examine the effects of Non-Invasive Brain stimulation on impulsive behaviour in patients diagnosed with Borderline Personality Disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)

Conditions

Borderline Personality Disorder

Keywords

impulsivity; Non-Invasive Brain Stimulation; Psychotherapy

Outcome Measures

Primary Outcomes (1)

• The effect of NIBS on impulsivity (UPPS- Behavioral Impulsive scale)

  Patients with BPD will complete UPPS impulsive behavioral scale, a self reported questionnaire, before the first tDCS session and after they complete the 10 sessions of tDCS sessions. this questionnaire consists of 45 questions with 4 likert scale range for each question. The questionnaire is divided into 4 subscales: Urgency, lack of premeditation, lack of perseverance, sensation seeking.

  2-week stimulation session

Secondary Outcomes (3)

• The effect of tDCS on BPD severity overall ( Borderline Personality Disorder Severity Index: BPDSI)

  3 months

• The Effect of tDCS on Risk taking ( an impulsive behavior dimension)

  2 weeks

• the effect of tDCS on depressive symptoms in BPD (Montgomery-Asberg Depression Rating Scale (MADRS))

  2 weeks

Study Arms (1)

Patients with BPD assigned to the trial of 10 active tDCS sessions followed by psychotherapy

EXPERIMENTAL

Patients diagnosed with Borderline Personality disorder and BPDSI score is \> or = 17 will be assigned for active tDCS session (NeuroConn, Germany) candidates will have 20-minute session per day for 10 weekdays in 2 weeks. Then they will attend short term psychotherapy session for 3 months.

Device: NeuroConn

Interventions

NeuroConn DEVICE

A neurostimulation decivse that works be generating weak electric current via Electrodes. These electrodes placed on a specific cerebral location, where the defect assumed to be there) to modulate the neuronal activity. This neuronal modulation does not induce or fire action potential but it facilitate action potentials and cerebral interconnection as well corticolimbic connection)

Also known as: tDCS, transcranial Direct Current Stimulation

Patients with BPD assigned to the trial of 10 active tDCS sessions followed by psychotherapy

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical Diagnosis of Borderline Personality Disorder (DSM-V)
• Resident of Great Montreal
• Ability to make decision
• Clinical score is equal or more than 17 in Borderline Personality Disorder Severity Index (BPDSI)
• resident of greater Montreal Area,

You may not qualify if:

• material Metal in the brain
• History of seizure or epilepsy
• severe scalp irritation or eczema
• recent scares, cut wounds, tattoo on the scalp
• severe substance use disorder
• clinical diagnosis of severe mood disorders o
• Active psychotic episode
• Pregnancy

Sponsors & Collaborators

• Ciusss de L'Est de l'Île de Montréal: lead
• Dr. Lionel Cailhol, chef of psychiatry department at Montreal Psychiatric Institute (IUSMM): collaborator

Study Sites (1)

Centre Recherche_ Institut Univesitaire de Santé Mentale à Montréal

Montreal, Quebec, H1N 3M5, Canada

Location

Related Publications (3)

• Lisoni J, Miotto P, Barlati S, Calza S, Crescini A, Deste G, Sacchetti E, Vita A. Change in core symptoms of borderline personality disorder by tDCS: A pilot study. Psychiatry Res. 2020 Sep;291:113261. doi: 10.1016/j.psychres.2020.113261. Epub 2020 Jun 28.

  PMID: 32622171 BACKGROUND

• Lisoni J, Barlati S, Deste G, Ceraso A, Nibbio G, Baldacci G, Vita A. Efficacy and tolerability of Brain Stimulation interventions in Borderline Personality Disorder: state of the art and future perspectives - A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 8;116:110537. doi: 10.1016/j.pnpbp.2022.110537. Epub 2022 Feb 15.

  PMID: 35176417 BACKGROUND

• Teti Mayer J, Chopard G, Nicolier M, Gabriel D, Masse C, Giustiniani J, Vandel P, Haffen E, Bennabi D. Can transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Mar 2;98:109814. doi: 10.1016/j.pnpbp.2019.109814. Epub 2019 Nov 9.

  PMID: 31715284 RESULT

MeSH Terms

Conditions

Borderline Personality Disorder; Impulsive Behavior

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Behavior

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master's Student

Model Details: we recruited 10 patients who attended a 10-session of tDCS stimulation. Each session lasted for 20 minutes in a 2-week.

Study Record Dates

• First Submitted: March 29, 2022
• First Posted: July 12, 2022
• Study Start: May 10, 2021
• Primary Completion: March 30, 2022
• Study Completion: July 20, 2022
• Last Updated: February 14, 2023

Record last verified: 2023-02

Locations

CA (1)