Sensori-motor and Perceptual Functions of the PPC.

NCT03286686 | Recruiting

• 2 other identifiers: 69HCL17_03412017-A02562-51
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles. The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning. In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests. Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

Conditions

Healthy Volunteers; Optic Ataxia

Keywords

optic ataxia; posterior parietal cortex functions; multisensory integration

Outcome Measures

Primary Outcomes (3)

• response error - number of pointing error

  Day 0 after each stimulation

• response error -measure of reaction times

  Day 0 after each stimulation

• response error - percentage of right responses

  Day 0 after each stimulation

Study Arms (6)

Experience 1

EXPERIMENTAL

Behavioral: point targets

Experience 2

EXPERIMENTAL

Behavioral: point targets

Experience 3

EXPERIMENTAL

Behavioral: tactile stimulation

Experience 4

EXPERIMENTAL

Behavioral: visual images

Experience 5

EXPERIMENTAL

Behavioral: visual images

Experience 6

EXPERIMENTAL

Behavioral: visual images

Interventions

point targets BEHAVIORAL

In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.

Experience 1; Experience 2

tactile stimulation BEHAVIORAL

In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.

Experience 3

visual images BEHAVIORAL

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Experience 4; Experience 5; Experience 6

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients and healthy subjects:
• male and female, age from 18 to 75 years included
• normal vision or corrected vision
• covered by social security
• signed written informed consent
• Patients:
• neurological injury in posterior parietal cortex supported by a cerebral MRI
• present optic ataxia symptoms Healthy subjects
• no known neurological injury

You may not qualify if:

• \- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

U1028 INSERM - CNRS UMR 5292 Equipe ImpAct

Bron, 69500, France

RECRUITING

Study Officials

• Laure PISELLA, PhD

  INSERM U1028 - Impact - CRNL

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Laure PISELLA, PhD

CONTACT

4 72 91 34 05; laure.pisella@inserm.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 14, 2017
• First Posted: September 18, 2017
• Study Start: February 22, 2018
• Primary Completion (Estimated): February 22, 2031
• Study Completion (Estimated): February 22, 2031
• Last Updated: January 20, 2026

Record last verified: 2026-01

Locations

FR (1)