NCT03282175

Brief Summary

The aim of this study was to investigate the acute and chronic effect of elastic resistance exercise in elderly women living in a nursing home. The primary outcome was the functional performance and hand grip strength. The secondary outcomes were myokines and inflammatory markers analysis.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2016

Shorter than P25 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 15, 2016

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2016

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

September 6, 2017

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 13, 2017

Completed
Last Updated

September 28, 2017

Status Verified

September 1, 2017

Enrollment Period

6 months

First QC Date

September 6, 2017

Last Update Submit

September 26, 2017

Conditions

Exercise

Keywords

BDNFinterleukin-15interleukin-8resistinSPPB

Outcome Measures

Primary Outcomes (1)

  • Functional performance

    A short battery of physical performance tests (SPPB) was used to assess baseline and post-training lower extremity function (0-12 point scale).

    1 week

Secondary Outcomes (2)

  • Acute effect of resistance exercise

    4 hours

  • Biochemical analysis of chronic effect of resistance training

    2 weeks

Study Arms (3)

Exercise

EXPERIMENTAL

Participant in this group performed an acute resistance exercise protocol. The exercise protocol consisted of general warm-up of 10 min, followed by 8 exercises with 2 sets of 8 repetition and 1 min between sets.

Other: Exercise

Training

EXPERIMENTAL

Participants allocated to intervention group initiated the progressive resistance training program of moderate intensity, with three weekly sessions throughout the 12-week treatment period.

Other: Training

Control group

ACTIVE COMPARATOR

Participants allocated to control group did not receive any placebo or treatment.

Other: Control group

Interventions

ExerciseOTHER

Exercise session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.

Exercise
TrainingOTHER

Each training session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.

Training
Control groupOTHER

The control group did not receive any treatment.

Control group

Eligibility Criteria

Age65 Years - 99 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsFemale nursing home residents
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • nursing home residents
  • participants did not perform any regular resistance training

You may not qualify if:

  • immobility
  • implantable cardiac peacemaker
  • severe dementia
  • terminal illness

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (9)

  • Argiles JM, Lopez-Soriano FJ, Busquets S. Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity. Drug Discov Today. 2009 Feb;14(3-4):208-13. doi: 10.1016/j.drudis.2008.10.010. Epub 2008 Dec 16.

    PMID: 19041416BACKGROUND

  • Busquets S, Figueras M, Almendro V, Lopez-Soriano FJ, Argiles JM. Interleukin-15 increases glucose uptake in skeletal muscle. An antidiabetogenic effect of the cytokine. Biochim Biophys Acta. 2006 Nov;1760(11):1613-7. doi: 10.1016/j.bbagen.2006.09.001. Epub 2006 Sep 12.

    PMID: 17056184BACKGROUND

  • Geroldi D, Minoretti P, Emanuele E. Brain-derived neurotrophic factor and the metabolic syndrome: more than just a hypothesis. Med Hypotheses. 2006;67(1):195-6. doi: 10.1016/j.mehy.2006.02.001. Epub 2006 Mar 20. No abstract available.

    PMID: 16545915BACKGROUND

  • Martins WR, Safons MP, Bottaro M, Blasczyk JC, Diniz LR, Fonseca RM, Bonini-Rocha AC, de Oliveira RJ. Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial. BMC Geriatr. 2015 Aug 12;15:99. doi: 10.1186/s12877-015-0101-5.

    PMID: 26265075BACKGROUND

  • Oesen S, Halper B, Hofmann M, Jandrasits W, Franzke B, Strasser EM, Graf A, Tschan H, Bachl N, Quittan M, Wagner KH, Wessner B. Effects of elastic band resistance training and nutritional supplementation on physical performance of institutionalised elderly--A randomized controlled trial. Exp Gerontol. 2015 Dec;72:99-108. doi: 10.1016/j.exger.2015.08.013. Epub 2015 Sep 2.

    PMID: 26341720BACKGROUND

  • Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G, Magosso R, Baldissera V, Cavaglieri C, Perez S. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci. 2009 Dec;27(14):1607-15. doi: 10.1080/02640410903352923.

    PMID: 19967592BACKGROUND

  • Pereira DS, de Queiroz BZ, Miranda AS, Rocha NP, Felicio DC, Mateo EC, Favero M, Coelho FM, Jesus-Moraleida F, Gomes Pereira DA, Teixeira AL, Maximo Pereira LS. Effects of physical exercise on plasma levels of brain-derived neurotrophic factor and depressive symptoms in elderly women--a randomized clinical trial. Arch Phys Med Rehabil. 2013 Aug;94(8):1443-50. doi: 10.1016/j.apmr.2013.03.029. Epub 2013 Apr 18.

    PMID: 23602881BACKGROUND

  • Troseid M, Lappegard KT, Claudi T, Damas JK, Morkrid L, Brendberg R, Mollnes TE. Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. Eur Heart J. 2004 Feb;25(4):349-55. doi: 10.1016/j.ehj.2003.12.006.

    PMID: 14984925BACKGROUND

  • Yeo NH, Woo J, Shin KO, Park JY, Kang S. The effects of different exercise intensity on myokine and angiogenesis factors. J Sports Med Phys Fitness. 2012 Aug;52(4):448-54.

    PMID: 22828466BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

ExerciseControl Groups

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological PhenomenaEpidemiologic Research DesignEpidemiologic MethodsInvestigative TechniquesResearch DesignMethods

Study Officials

  • Felicita Urzi, MSc

    University of Primorska Faculty of Mathematics, Natural Sciences and Information Technologies

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 6, 2017

First Posted

September 13, 2017

Study Start

January 15, 2016

Primary Completion

June 30, 2016

Study Completion

June 30, 2016

Last Updated

September 28, 2017

Record last verified: 2017-09