The Effects of Whey vs. Collagen on MPS

NCT03281434 | Completed

• 1 other identifier: HIREB 3916
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 2

Brief Summary

With aging there is a natural loss of muscle mass and strength called sarcopenia, which increases the risk of falls and metabolic disease (i.e. Type II diabetes) and decreases the ability to perform activities of daily living. Eating protein and doing resistance exercise both increase the body's ability to make muscle protein, which is important to offset losses in muscle mass; however, older adults have a lower appetite and do not consume enough calories or protein to crease muscle and as such investigations in this population are needed. The amino acid (the building blocks of proteins) leucine is known to increase the ability of protein to make muscle. In this study we will investigate the ability of beverages with different types of protein and leucine to create muscle in older men and women whoa re particularly vulnerable to muscle losses and do not eat enough protein and are understudied in this area.

Conditions

Aging

Keywords

Skeletal muscle; Protein synthesis; Protein ingestion; Resistance exercise

Outcome Measures

Primary Outcomes (2)

• Acute myofibrillar muscle protein synthesis

  Assessed with stable isotope tracer infusion (\[L-ring\] 13C6 phenylalanine)

  8 hours

• Medium length myofibrillar muscle protein synthesis

  Assessed with deuterated water

  7 days

Secondary Outcomes (1)

• Fasted glucose, insulin and oxidative stress (IL6, TNF-a, CRP)

  Assessed every 2 days throughout the 7 day monitoring period

Study Arms (2)

Collagen peptide

ACTIVE COMPARATOR

Supplement will be delivered twice daily (30g per supplement) of hydrolyzed collagen peptides

Dietary Supplement: Collagen peptide

Whey protein

EXPERIMENTAL

Supplement will be delivered twice daily (30g per supplement) of whey protein isolate

Dietary Supplement: Whey protein isolate

Interventions

Collagen peptide DIETARY_SUPPLEMENT

Low leucine content protein supplement to be consumed twice daily

Collagen peptide

Whey protein isolate DIETARY_SUPPLEMENT

High quality protein (DIAAS score), high leucine supplement, to be consumed twice daily

Whey protein

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy
• Ambulatory, and able to perform exercise
• Active (\~3500-10,000 steps per day)

You may not qualify if:

• Smoker
• Diabetic
• Chronic conditions
• Consumption of medications known to affect muscle protein synthesis
• Statin myalgia
• Allergy to milk protein

Sponsors & Collaborators

• McMaster University: lead

Study Sites (2)

Exercise Metabolism Research Laboratory, McMaster Univeristy

Hamilton, Ontario, L8S 4K1, Canada

Location

Ivor Wynne Center

Hamilton, Ontario, L8S4K1, Canada

Location

Related Publications (1)

• Oikawa SY, Kamal MJ, Webb EK, McGlory C, Baker SK, Phillips SM. Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. Am J Clin Nutr. 2020 Mar 1;111(3):708-718. doi: 10.1093/ajcn/nqz332.

  PMID: 31919527 RESULT

Study Officials

• Stuart M Phillips, Ph.D.

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Double blind
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Parallel group design (with repeated measurements within each group)

Study Record Dates

• First Submitted: September 11, 2017
• First Posted: September 13, 2017
• Study Start: January 1, 2018
• Primary Completion: August 30, 2018
• Study Completion: August 1, 2019
• Last Updated: February 10, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)