Optimal Exercise Training and Nutrition Supplementation in Older Men

NCT02281331 | Completed

• 1 other identifier: REB 14-677
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.

Conditions

Aging

Outcome Measures

Primary Outcomes (1)

• Muscle mass

  DXA, ultrasound

  12 weeks

Secondary Outcomes (4)

• Muscle protein synthesis

  12 weeks

• Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain

  12 weeks

• Glycemic control

  12 weeks

• Cognitive function

  12 weeks

Study Arms (2)

Supplement

ACTIVE COMPARATOR

Each day, participants in this group will receive a supplement that provides a total of protein, creatine monohydrate, calcium, vitamin D and carbohydrate. This supplement will be provided to participants in beverage format, twice daily.

Dietary Supplement: Supplement

Placebo

PLACEBO COMPARATOR

The placebo will provide participants with maltodextrin (carbohydrate) and sucrose.

Dietary Supplement: Supplement

Interventions

Supplement DIETARY_SUPPLEMENT

supplement/placebo plus exercise training

Placebo; Supplement

Eligibility Criteria

• Age: 60 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sedentary (no participation in a structured exercise training program in past 6 months)
• BMI between 18.5-30.0 kg/m2
• Weight stable for past 6 months
• Normal resting blood pressure, or stage I hypertension

You may not qualify if:

• Smoking
• Use of simvastatin or atorvastatin
• Use of non-steroidal anti-inflammatory drugs
• Injuries that prevent safe-participation in an exercise training program
• Prescription blood thinners
• Diabetes or other metabolic disorders
• Cardiac or gastro-intestinal problems
• Infectious disease or cancer

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

McMaster Univeristy

Hamilton, Ontario, L8S 4K1, Canada

Location

Related Publications (4)

• Bell KE, Fang H, Snijders T, Allison DJ, Zulyniak MA, Chabowski A, Parise G, Phillips SM, Heisz JJ. A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index in Healthy Older Men: A Randomized Controlled Trial. Front Aging Neurosci. 2019 May 9;11:107. doi: 10.3389/fnagi.2019.00107. eCollection 2019.

  PMID: 31143111 DERIVED

• Bell KE, Brook MS, Snijders T, Kumbhare D, Parise G, Smith K, Atherton PJ, Phillips SM. Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men. Front Nutr. 2019 Apr 11;6:40. doi: 10.3389/fnut.2019.00040. eCollection 2019.

  PMID: 31032258 DERIVED

• Snijders T, Bell KE, Nederveen JP, Saddler NI, Mazara N, Kumbhare DA, Phillips SM, Parise G. Ingestion of a Multi-Ingredient Supplement Does Not Alter Exercise-Induced Satellite Cell Responses in Older Men. J Nutr. 2018 Jun 1;148(6):891-899. doi: 10.1093/jn/nxy063.

  PMID: 29878269 DERIVED

• Bell KE, Snijders T, Zulyniak M, Kumbhare D, Parise G, Chabowski A, Phillips SM. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLoS One. 2017 Jul 18;12(7):e0181387. doi: 10.1371/journal.pone.0181387. eCollection 2017.

  PMID: 28719669 DERIVED

MeSH Terms

Interventions

Dietary Supplements

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Stuart Phillips, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 8, 2014
• First Posted: November 3, 2014
• Study Start: October 1, 2014
• Primary Completion: December 1, 2016
• Study Completion: May 1, 2018
• Last Updated: August 16, 2018

Record last verified: 2018-08

Locations

CA (1)