Tea Consumption and Cognitive Performance in the Very Old

NCT03278743 | Completed

• 1 other identifier: UNewcastle
• Study Type: observational
• Target: 1,042
• Locations: 1 country
• Sites: 1

Brief Summary

Studies have found a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old defined as individuals aged 85 years and over. Therefore, we hypothesized that higher tea consumption was associated with better global and domain-specific cognitive function. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed. The Newcastle 85+ Study was a longitudinal (5-years), population-based cohort study of individuals aged 85+ years in North East England, United Kingdom. The final sample included 676 community-dwelling and institutionalized men and women recruited through general medical practices. Baseline tea consumption was assessed through a 2x24-hr multiple pass recall and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function through the standardized mini-mental state examination and the cognitive drug research system. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline.

Conditions

Cognition

Keywords

tea; cognition; very old; Newcastle 85+; epidemiology

Outcome Measures

Primary Outcomes (2)

• Standardized mini-mental state examination

  Measure of global cognition (Score 0-30)

  Baseline

• Rate of decline of the standardized mini-mental state examination

  Measure of global cognition (Score 0-30)

  Baseline to 5 years follow-up

Secondary Outcomes (8)

• Simple reaction time

  Baseline

• Rate of reaction speed decline

  Baseline to 3 years follow-up

• Choice reaction time

  Baseline

• Rate of reaction choice decline

  Baseline to 3 years follow-up

• Digit vigilance task

  Baseline

Study Arms (2)

low to moderate tea consumption

consumption of 0.4 to 4.6 cups of tea (200 ml) per day (n=463)

Other: Cognitive performance and cognitive decline

High tea consumption

consumption of 4.6 to 11.9 cups of tea (200 ml) per day (n=213)

Other: Cognitive performance and cognitive decline

Interventions

Cognitive performance and cognitive decline OTHER

Assess the global and domain specific (memory, speed and attention) cognitive function at baseline and over 5 years in the high vs. low/moderate tea consumption groups

High tea consumption; low to moderate tea consumption

Eligibility Criteria

• Age: 85 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community-dwelling and institutionalized men and women recruited through general medical practices in North East England, UK (n=676) and born in 1921 (85 years old at baseline).

You may qualify if:

• Born in 1921
• Permanently registered with a participating general practice in Newcastle upon Tyne or North Tyneside primary care trusts in the UK

You may not qualify if:

• End-stage illness
• Individuals who might pose a safety risk to a nurse visiting alone, with dementia
• Clinical diagnosis of dementia at baseline

Sponsors & Collaborators

• Newcastle University: lead

Study Sites (1)

Newcastle University

Newcastle upon Tyne, NE17RU, United Kingdom

Location

Study Officials

• Tom Kirkwood

  Newcastle University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2017
• First Posted: September 12, 2017
• Study Start: June 1, 2006
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: September 12, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will share
• Access Criteria: Data request

Locations

GB (1)