Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units

NCT03270774 | Completed

• 1 other identifier: CVC Study
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract. This study set out to determine the prevalence and associated factors for central venous catheter colonisation among critically ill patient. No data exists in this clinical setting addressing this topic. Methods: The study population included 100 participants with central venous catheters in situ for at least 24 hours. Catheter tip (distal 5-cm segment) and blood cultures (10mls peripheral blood) were obtained at the time of catheter removal.

Conditions

Sepsis; Septic Shock; Post-cardiac Surgery; Post-Cardiorespiratory Arrest Coma; Head Injury; Hypoxic Brain Damage; Acute Liver Failure; Diabetic Ketoacidotic Hyperglycaemic Coma

Outcome Measures

Primary Outcomes (1)

• Prevalence of central venous catheter colonisation

  Of the patients that had central venous catheter inserted, how many of them developed central venous catheter colonisation

  up to 14 days

Secondary Outcomes (2)

• Prevalence of Central venous catheter associated bloodstream infections

  Up to 48 hours after removal of central venous catheter

• Factors associated with central venous catheter colonisation

  up to 14 days

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population All the critically ill patients with CVCs admitted to the general ICUs in the 4 hospitals above during the study period and who met the inclusion criteria

You may qualify if:

• Patients of all age groups were included in this study
• All critically ill patients admitted to the ICU with Central Venous Catheters in situ
• Written informed consent/assent
• Waiver of consent for unconscious patients with no attendant/valid surrogate respondent to provide the required information

You may not qualify if:

• Patients who were already on treatment for CVC-related infectious complications.

Sponsors & Collaborators

• Makerere University: lead

MeSH Terms

Conditions

Sepsis; Shock, Septic; Craniocerebral Trauma; Hypoxia, Brain; Liver Failure, Acute

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock; Trauma, Nervous System; Nervous System Diseases; Wounds and Injuries; Brain Diseases; Central Nervous System Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Liver Failure; Hepatic Insufficiency; Liver Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 30, 2017
• First Posted: September 1, 2017
• Study Start: April 19, 2016
• Primary Completion: April 10, 2017
• Study Completion: April 19, 2017
• Last Updated: September 1, 2017

Record last verified: 2017-08