A Prognosis and Predicting Genetic Study of Lung Cancer

NCT03234179 | Not Yet Recruiting DMC

• 1 other identifier: 201705110RIND
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

Lung cancer is a leading cause of cancer mortality among adults worldwide. The incidence rates of lung cancer among never smoking females in some parts of East Asia are among the highest in the world. The adenocarcinoma of lung being the most frequently identified histological type is more weakly associated with smoking, and often occurs in females and never-smokers. Although family history of lung cancer has been associated with histological subtypes, the inherited susceptibility factors that affect specific histology are unknown. Genetic factors that determine individual predisposition to lung cancer have been identified via genome-wide association studies. These known common loci, however, explain only a small fraction of the familial risk of lung cancer. The hypothesis of this study is that there are genetic factors that confer inherited susceptibility among patients with primary non-small-cell lung cancer (NSCLC).

Conditions

Lung Cancer; Genetic Predisposition to Disease

Keywords

Non small cell lung cancer; Genetic study

Outcome Measures

Primary Outcomes (1)

• Genetic information of lung cancer patients

  Collect study subjects' blood sample and analysis with Genome-wide SNP genotyping

  One week after the study subjects sign the permit of informed consents

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with diagnosis of primary non small cell lung cancer

You may qualify if:

• The patient's family (within third-degree relatives) has at least one diagnosed of primary non-small cell lung cancer.
• The patient was diagnosed of primary non-small cell lung cancer at the age \< 45 years old.

You may not qualify if:

• Patients without the diagnosis of primary non-small cell lung cancer.
• Patients who are combined with other malignancy and ongoing chemotherapy / radiation therapy.
• Patients combined with coagulopathy.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Biospecimen

Retention: SAMPLES WITH DNA

The samples are stored at the lab of NTUH hospital with protected of security. The information of the study subjects will be reached only by investigator of this study.

MeSH Terms

Conditions

Lung Neoplasms; Genetic Predisposition to Disease; Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Carcinoma, Bronchogenic; Bronchial Neoplasms

Study Officials

• Jin-Shing Chen, PhD

  National Taiwan University Hospital

  STUDY DIRECTOR

Central Study Contacts

Tung-Ming Tsai, MD

CONTACT

+886972792011; eldorado0607@gmail.com

Jin-Shing Chen, PhD

CONTACT

+8869721451; chenjs@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2017
• First Posted: July 31, 2017
• Study Start: August 1, 2017
• Primary Completion: August 1, 2020
• Study Completion (Estimated): August 1, 2037
• Last Updated: August 1, 2017

Record last verified: 2017-07

Data Sharing

• IPD Sharing: Will not share