Serotonin and Motor Plasticity
The Effects of Serotonergic Challenge on Motor Learning and Neuroplasticity
1 other identifier
interventional
60
1 country
1
Brief Summary
With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy humans.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Apr 2017
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2017
CompletedFirst Submitted
Initial submission to the registry
May 18, 2017
CompletedFirst Posted
Study publicly available on registry
May 22, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2017
CompletedMay 22, 2017
May 1, 2017
8 months
May 18, 2017
May 19, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Pinch Force Task.
The primary outcome measure will be reaction time and accuracy of motor responses, as measured by the Pinch Force Task. This will be applied to both the experimental (SSRI) and control (Placebo) groups.
1 week
Study Arms (2)
Interventional group
EXPERIMENTALHalf of the participants (n = 30) will receive 20mg of the SSRI Escitalopram.
Control group
PLACEBO COMPARATORHalf of the participants ( n= 30) will receive the placebo.
Interventions
Experimental group participants (n = 30) will receive 20 mg of Escitalopram for 7 days.
Eligibility Criteria
You may qualify if:
- female
- right-handed
- healthy
- has taken oral contraceptives (ovulation inhibitor) continuously for at least 3 months
- has read and agreed to study parameters
You may not qualify if:
- tattoos on head or neck
- non-removable metal on or in body
- alcohol abuse
- is currently taking medication
- smokes more than 3 cigarettes per day
- positive drug test
- pregnancy
- plays an instrument professionally
- plays videogames more than 2 hours per week
- is a professional athlete
- suffers from migraines
- has taken part in another study, where motor learning skills and/or medication is a factor, in the last 3 months
- heart rhythm disorders (long QT)
- hypertension
- calcium or magnesium deficiency
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Max Planck Institute for Cognition and Brain Sciences
Leipzig, Saxony, 04103, Germany
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Arno Villringer
Max Planck Institute for Human Cognitive and Brain Sciences
- STUDY DIRECTOR
Julia Sacher
Max Planck Institute for Human Cognitive and Brain Sciences
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Masking Details
- Double-blind
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 18, 2017
First Posted
May 22, 2017
Study Start
April 1, 2017
Primary Completion
November 30, 2017
Study Completion
November 30, 2017
Last Updated
May 22, 2017
Record last verified: 2017-05
Data Sharing
- IPD Sharing
- Will not share