Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes

NCT03152747 | Completed

• 1 other identifier: Myopred
• Study Type: observational
• Target: 609
• Locations: 1 country
• Sites: 1

Brief Summary

Phacoemulsification with implantation of posterior chamber lenses represents the gold standard of care for patients needing lens surgery, but there is an increased risk of developing pseudophakic retinal detachment after surgery. Especially myopic patients have an even higher risk of pseudophakic retinal detachment compared to the general population. The aim of this multicenter study is to document the presence and/or post-operative development of posterior vitreous detachment (PVD) and to assess its influence on the incidence of retinal detachment (RD) in myopes in a time period of three and five years after lens surgery. 618 eyes of patients scheduled for regular lens surgery will be included, defined by an axial length of 25.0 mm or more. To examine the vitreous status, all patients will receive a comprehensive eye examination pre-operatively, including funduscopy with assessment of a Weiss ring and optical coherence tomography (OCT). Patients will be divided into two groups, group A with pre-operative complete PVD and group B with no/partial PVD. Group A will be invited for one follow-up visit (two months post-operatively) followed up by telephone interviews at one, two, three and five years after surgery to determine occurrence of pseudophakic retinal detachment. Group B will be invited for follow-up examinations at two months, six months and one year after surgery to document occurrence of PVD (if a PVD is present at one of the follow-ups, no more visits are necessary). Two, three and five years after surgery, all patients from group B will be interviewed by telephone, as in group A, to document the occurrence of pseudophakic retinal detachment. In the recent literature the association between the occurrence of PVD pre-/post-operative and RD after lens surgery is well documented but not described for myopic patients. The results of this multicenter study should help to tackle the problem of RD prediction in myopic patients depending on their pre-operative vitreous status, especially in the setting of refractive lens exchange.

Conditions

Myopia; Cataract; Pseudophakic Retinal Detachment; Refractive Lens Exchange

Outcome Measures

Primary Outcomes (2)

• PVD status

  Number of patients with preoperative and/or post-operatively developed posterior vitreous detachment (PVD)

  1 year

• Incidence of RD

  Influence of PVD on the incidence of retinal detachment (RD) in myopes after lens surgery.

  5 years

Interventions

ultrasound, b-scan

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study population: target 618. The participants will be selected by the clinical investigators at several ophthalmological centres in Austria, Belgium, Spain, Norway and the Netherlands. As the study population is already scheduled for cataract surgery / refractive lens exchange, recruitment will be performed directly in these centres at the pre-assessment visits. At this visit, optical biometry is performed and patients with suitable axial eye lengths will be screened. If all inclusion and no exclusion criteria are met the patients will be asked to participate in the trial.

You may qualify if:

• Minimum 21 years of age
• Patients scheduled for lens surgery with an axial eye length of 25.0 mm or more
• Availability, willingness, sufficient cognitive awareness to comply with examination procedures
• Ability to sign informed consent

You may not qualify if:

• Patients with combined surgery (e.g. combined phacoemulsification and vitrectomy or trabeculectomy or DSAEK)
• Patients with previous intraocular surgery (except any kind of laser surgery e.g. retinopexy, refractive laser surgery)
• Patients with recurrent severe anterior or posterior segment inflammation or uveitis of unknown aetiology, or any disease producing an inflammatory reaction in the eye
• Any ophthalmological pathology with the potential to compromise the measurements (e.g. mature/very dense cataract, fixation difficulties)
• Penetrating ocular trauma
• Previous history of retinal detachment
• Patient is pregnant, plans to become pregnant, is lactating or has another condition associated with the fluctuation of hormones that could lead to refractive changes
• Patients participating in another study

Sponsors & Collaborators

• Prim. Prof. Dr. Oliver Findl, MBA: lead
• European Society of Cataract and Refractive Surgeons: collaborator

Study Sites (1)

Vienna Institute for Research in Ocular Surgery

Vienna, Vienna, 1140, Austria

Location

MeSH Terms

Conditions

Myopia; Cataract

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases; Lens Diseases

Study Officials

• Oliver Findl, Prof. Dr.

  Vienna Institute for Research in Ocular Surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principle Investigator, Sponsor

Study Record Dates

• First Submitted: April 19, 2017
• First Posted: May 15, 2017
• Study Start: April 27, 2017
• Primary Completion: October 30, 2024
• Study Completion: September 14, 2025
• Last Updated: March 13, 2026

Record last verified: 2026-03

Locations

AU (1)