NCT03751462

Brief Summary

Compare visual acuity of patients after cataract surgery with implantation of an IOL clinical outcome measure in eyes with and without pseudoexfoliation syndrome or history of ocular trauma.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2018

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2018

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

November 21, 2018

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 23, 2018

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2019

Completed
Last Updated

November 23, 2018

Status Verified

November 1, 2018

Enrollment Period

1.6 years

First QC Date

November 21, 2018

Last Update Submit

November 21, 2018

Conditions

Keywords

CataractPseudoexfoliationTraumatic cataract

Outcome Measures

Primary Outcomes (1)

  • IOL wobble

    IOL wobble, tilt and decentration will be assessed in patients with PEX or traumatic cataract using the Purkinjemeter device. The smaller the amount of IOL wobble, tilt and decentration, the better the results.

    12 months

Secondary Outcomes (1)

  • Best corrected distance visual acuity (BCDVA)

    12 months

Study Arms (1)

Pseudoexfoliation syndrome

EXPERIMENTAL

Patients with pseudoexfoliation syndrome or traumatic cataract will be examined using the Purkinjemeter device concerning IOL wobble, tilt and decentration

Device: Purkinjemeter

Interventions

The Purkinjemeter will be used for assessment of IOL wobbling, tilt and decentration in patients with pseudoexfoliation syndrome or traumatic cataract

Pseudoexfoliation syndrome

Eligibility Criteria

Age21 Years - 105 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Cataract with the indication for surgery (decrease in visual acuity, blurred vision or glare ) for both groups (study and control group)
  • Age 18 and older
  • Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
  • Written informed consent
  • Pseudoexfoliation syndrome or history of blunt ocular trauma - for the study group

You may not qualify if:

  • Pseudoexfoliation syndrome or history of blunt ocular trauma - for the control group
  • History of penetrating ocular trauma
  • Relevant other ophthalmic diseases that could affect corneal transparency or the ability for fixation
  • Any relevant ophthalmic disease leading to limited visual acuity prognosis after cataract surgery
  • In case of pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vienna Institute for Research in Ocular Surgery (VIROS)

Vienna, 1140, Austria

RECRUITING

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens DiseasesEye Diseases

Central Study Contacts

Sophie Mädel, MD

CONTACT

Nino Hirnschall, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 21, 2018

First Posted

November 23, 2018

Study Start

May 1, 2018

Primary Completion

December 1, 2019

Study Completion

December 1, 2019

Last Updated

November 23, 2018

Record last verified: 2018-11

Locations