NCT03749161

Brief Summary

Compare low-add multifocal IOLs with monofocal IOLs to evaluate if patients in the low-add multifocal IOL group have better unaided distance visual acuity compared to the monofocal group.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2018

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2018

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

November 19, 2018

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 21, 2018

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2019

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2020

Completed
Last Updated

November 21, 2018

Status Verified

November 1, 2018

Enrollment Period

1.7 years

First QC Date

November 19, 2018

Last Update Submit

November 20, 2018

Conditions

Keywords

Cataract SurgeryLow-add intraocular lens

Outcome Measures

Primary Outcomes (1)

  • Spectacle independence questionnaire

    Spectacle independence will be assessed using a questionnaire. In this questionnaire the patient will be asked about usage of spectacles for far, near and intermediate distance. Best result will be if the patient is independent from any spectacles in the different distances.

    12 months

Secondary Outcomes (2)

  • Best Corrected Distance Visual Acuity and Uncorrected Intermediate Visual Acuity

    12 months

  • Titmus Fly Stereo test

    12 months

Study Arms (2)

Lentis comfort

EXPERIMENTAL

Patient will receive the low-add multifocal IOL during cataract surgery

Device: Low-add multifocal IOL

Lentis L-313

EXPERIMENTAL

Patient will receive the monofocal IOL Lentis L-313 during cataract surgery

Device: Monofocal IOL

Interventions

Lentis comfort, low-add multifocal, IOL

Lentis comfort

Lentis L-313, monofocal IOL

Lentis L-313

Eligibility Criteria

Age21 Years - 105 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age-related cataract in both eyes
  • Scheduled for bilateral cataract surgery
  • Motivated to be less spectacle dependant in the distance to intermediate vision range
  • Patients with an expected BCDVA of 0.8 snellen score or better after surgery
  • Patients with the need of an IOL Power in the range of 10 to 30D (biometry performed with the IOL master 700)
  • Age 21 and older
  • Written informed consent prior to recruitment

You may not qualify if:

  • Pregnancy (pregnancy test will be taken pre-operatively in women of reproductive age)
  • Retinopathia pigmentosa
  • Chronic uveitis
  • Amblyopia
  • Pupil decentration \> 1mm center shift
  • preceded retinal surgery
  • preceded Laser-in-situ-Keratomileusis (LASIK)
  • Any ophthalmic abnormality that could compromise visual function or the measurements

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vienna Institute for Research in Ocular Surgery (VIROS)

Vienna, 1140, Austria

RECRUITING

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens DiseasesEye Diseases

Central Study Contacts

John Falasinnu, MD

CONTACT

Nino Hirnschall, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 19, 2018

First Posted

November 21, 2018

Study Start

April 1, 2018

Primary Completion

December 1, 2019

Study Completion

January 1, 2020

Last Updated

November 21, 2018

Record last verified: 2018-11

Locations