Role of Acute Exercise Modality on Appetite Regulation and Energy Intake

NCT03143868 | Completed

• 2 other identifiers: 16-2697UL1TR001082-04
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

This study plans to learn more about how type of exercise influences measures of appetite regulation. In this study, investigators will be evaluating a resistance exercise session (using weight machines and free weights) and an aerobic exercise session (using a treadmill). Participants will also complete a sedentary control condition. A secondary purpose is to compare sex-based differences in appetite-indices in response to exercise. Therefore, the responses to aerobic and resistance exercise will also be compared between men and women.

Conditions

Appetite Regulation; Acute Exercise; Energy Intake

Keywords

acute exercise; resistance exercise; aerobic exercise; appetite; energy intake

Outcome Measures

Primary Outcomes (3)

• Change in Ghrelin Area Under the Curve (AUC)

  Concentration of ghrelin values, overtime for each arm of the study

  At baseline and every 30 minutes for 3 hours following a breakfast meal

• Change in Peptide YY (PYY) AUC

  Concentration of PYY values, overtime for each arm of the study

  At baseline and every 30 minutes for 3 hours following a breakfast meal

• Change in GLP-1 AUC

  Concentration of GLP-1 values, overtime for each arm of the study. Added in December 2017 following receipt of additional funding to add this measure)

  At baseline and every 30 minutes for 3 hours following a breakfast meal

Secondary Outcomes (5)

• Change in Hunger AUC

  At baseline and every 30 minutes for 3 hours following a breakfast meal

• Change in Satiety AUC

  At baseline and every 30 minutes for 3 hours following a breakfast meal

• Change in Prospective Food Consumption AUC

  At baseline and every 30 minutes for 3 hours following a breakfast meal

• Change in Ad libitum Energy Intake - in lab

  3 hours following breakfast meal on each arm

• Change in Ad libitum Energy Intake - free living

  For 3 days following each arm

Other Outcomes (2)

• Difference Between Men and Women in Appetite-Indices

  At baseline, every 30 minutes for 3 hours following a breakfast meal, and for 3 days following each arm

• Difference in Behavioral Economics Constructs (Delayed Discounting and Hypothetical Purchase Task)

  In the fed state, following completion of assigned exercise bout (or control bout).

Study Arms (3)

Aerobic Exercise

EXPERIMENTAL

Behavioral: Exercise Modality

Resistance Exercise

EXPERIMENTAL

Behavioral: Exercise Modality

No Exercise

PLACEBO COMPARATOR

Behavioral: Exercise Modality

Interventions

Exercise Modality BEHAVIORAL

The overall aim of this study is to compare how acute exercise modality (e.g. resistance exercise vs. aerobic exercise) differentially influence hormonal and behavioral indices of appetite regulation and ad libitum energy intake. Both conditions will also be compared to a non-exercise control condition.

Aerobic Exercise; No Exercise; Resistance Exercise

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• All ethnic groups and both genders
• Age: 18-55 yrs (changed in September 2018 because trial we are modeling enrollment criteria on \[NCT02047721\] changed age range, so we adjusted for this trial as well)
• BMI: 18.5-40 kg/m2 (changed in June 2018 from original range of 27-35 kg/m2 in order to improve recruitment. This is because recruitment within our prior BMI range had been slower than anticipated and potential participants that have expressed interest have screened out because of this. Given that we are still limiting enrollment criteria to adults who are inactive, it is likely that most will have body fat levels above normative standards, and therefore still be classified as having excess adiposity, even if their BMI is below 25 kg/m2. Furthermore, given the pilot nature of this work we believe it is important to complete the trial in a timely manner. We anticipate alterations to the enrollment criteria helping with this effort.)
• Weight stable within ±5% in the last 6 months
• Physically inactive (not meeting current physical activity guidelines, by self-report, no resistance training in previous 12-months)

You may not qualify if:

• Symptoms suggestive of CVD: chest pain, shortness of breath at rest or with mild exertion, syncope.
• Unable to exercise due to cardiac, pulmonary, neurologic or orthopedic reasons.
• Significant gastrointestinal disorders including: inflammatory bowel disease requiring treatment within the past year, chronic malabsorptive conditions, chronic diarrhea, or active gallbladder disease.
• Currently smoking and/or nicotine use within the past 6 months.
• Treatment with medications known to significantly affecting appetite, weight, energy metabolism, energy intake or energy expenditure in the last 6 months (e.g. systemic corticosteroids, appetite suppressants, lithium, stimulants, anti-psychotics, tricyclic antidepressants).
• Weight loss or weight gain of \>5% in past 6 months.
• History of surgical procedure for weight loss at any time (e.g. gastroplasty, gastric bypass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve); history of extensive bowel resection for other reasons.
• Currently pregnant (confirmed via urine pregnancy test), lactating or less than 6 months post-partum.
• Self-report of alcohol or substance abuse within the past 12 months.
• History of clinically diagnosed eating disorders including anorexia nervosa, bulimia, binge eating disorder, or score \>20 on the EATS-26. Participants with a score \>20 on the EATS-26 will be referred to their primary care physician for further evaluation.
• Major psychiatric disorder (e.g. diagnosis of schizophrenia, bipolar disorder, or other psychotic disorders).
• Current severe depression or history of severe depression within the previous year (based on reported history, study physician examination findings, and/or a score \>21 on the CES-D). Participants meeting any of these criteria will be referred to their primary care physician and/or the emergency department (based upon study physician determined level of severity).
• Significant food intolerances/allergies that cannot be accommodated by the CTRC Metabolic Kitchen.
• Currently participating in or planning to participate in any formal weight loss or physical activity programs or clinical trials.
• Other medical, psychiatric, or behavioral limitations that may interfere with participation (as determined by study physician).

Sponsors & Collaborators

• University of Colorado, Denver: lead
• National Center for Advancing Translational Sciences (NCATS): collaborator

Study Sites (1)

University of Colorado Denver - Anschutz Medical Campus

Aurora, Colorado, 80045, United States

Location

Related Publications (2)

• Tobin SY, Cornier MA, White MH, Hild AK, Simonsen SE, Melanson EL, Halliday TM. The effects of acute exercise on appetite and energy intake in men and women. Physiol Behav. 2021 Nov 1;241:113562. doi: 10.1016/j.physbeh.2021.113562. Epub 2021 Sep 10.

  PMID: 34516956 DERIVED

• Halliday TM, White MH, Hild AK, Conroy MB, Melanson EL, Cornier MA. Appetite and Energy Intake Regulation in Response to Acute Exercise. Med Sci Sports Exerc. 2021 Oct 1;53(10):2173-2181. doi: 10.1249/MSS.0000000000002678.

  PMID: 33831896 DERIVED

Study Officials

• Tanya M Halliday, PhD, RD

  University of Colorado, Denver

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 2, 2017
• First Posted: May 8, 2017
• Study Start: June 14, 2017
• Primary Completion: June 3, 2019
• Study Completion: June 3, 2019
• Last Updated: June 4, 2019

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)