NCT03141866

Brief Summary

This trial will take the form of a feasibility study; designed to assess the feasibility of a proposed future clinical trial in this setting. This proposed future clinical trial is proposed to assess the impact of physical activity, in the form of specialised chair based physical activity interventions, on the physiological, psychological, cognitive, social and emotional health, and functional capacity of geriatric populations with pre-existing frailty within a clinical hospital ward setting; recognising health as a holistic concept incorporating a multitude of inter-related dimensions. This feasibility study is single-centre (taking place in the Harborne Ward of the Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, United Kingdom).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2018

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 21, 2017

Completed
14 days until next milestone

First Posted

Study publicly available on registry

May 5, 2017

Completed
1.3 years until next milestone

Study Start

First participant enrolled

September 3, 2018

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 9, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 9, 2019

Completed
Last Updated

July 26, 2019

Status Verified

April 1, 2019

Enrollment Period

11 months

First QC Date

April 21, 2017

Last Update Submit

July 25, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Feasibility

    The primary dependent variable of this feasibility study will relate to the eight primary areas of focus of feasibility studies (Bowen et al. 2009), relating to: * Acceptability * Demand * Implementation * Practicality * Adaptation * Integration * Expansion and * Limited-efficacy testing These eight aforementioned areas (constituting the one variable of feasibility) will serve as the primary dependent variable for this study, in order to establish the feasibility of a proposed future clinical trial within this setting. The dependent variable of feasibility will be assessed through semi-structured interviews with participants post intervention, while focus groups will be utilised with both the intervention implementers and study support staff in order to assess the primary dependent variable of the study. Participant uptake and adherence records will also be employed throughout.

    Post-Intervention (2 weeks)

Secondary Outcomes (17)

  • Cortisol (Physiological Dependent Variable)

    Pre-intervention (baseline), and post-intervention (2 weeks)

  • Dehydroepiandrosterone-sulphate (DHEAS) (Physiological Dependent Variable)

    Pre-intervention (baseline), and post-intervention (2 weeks)

  • Serum cortisol : DHEAS ratio (Physiological Dependent Variable)

    Pre-intervention (baseline), and post-intervention (2 weeks)

  • C-reactive proteins (CRP) (Physiological Dependent Variable)

    Pre-intervention (baseline), and post-intervention (2 weeks)

  • Inflammatory Cytokine: Interleukin 6 (IL-6) (Physiological Dependent Variable)

    Pre-intervention (baseline), and post-intervention (2 weeks)

  • +12 more secondary outcomes

Study Arms (2)

Exercise Intervention 1: Move It Or Lose It (MIOLI)

EXPERIMENTAL

An established chair-based physical activity programme for older adults.

Other: Exercise Intervention 1: Move It Or Lose It (MIOLI)

Exercise Intervention 2: Machine-based resistance training

EXPERIMENTAL

Specialised, chair-based resistance training equipment for older adults.

Other: Exercise Intervention 2: Machine-based resistance training intervention

Interventions

An established chair-based physical activity programme for older adults.

Exercise Intervention 1: Move It Or Lose It (MIOLI)

Specialised, chair-based, pneumatic resistance training equipment for older adults.

Exercise Intervention 2: Machine-based resistance training

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Temporary residents within the Harborne 'living lab' ward of the Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, United Kingdom
  • ≥ 65 years of age
  • Frail according to the Fried Frailty criteria: meeting at least three of the five characteristics of frailty (Fried et al. 2001)
  • Have the capacity to speak and read in English
  • Anticipated by their care team to remain on the ward for approximately 14 days post enrolment into the study. This will be advised by the patient's care team.

You may not qualify if:

  • Currently taking part in any other clinical trial which could potentially have an impact upon or influences the findings of the current study
  • Currently terminally ill with life expectancy which is less than the duration of the study's interventions
  • Severe sensory impairment which would profoundly impact on their capacity to undergo the interventions, even once appropriate adaptations have been made.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Harborne Ward, Queen Elizabeth Hospital Birmingham

Birmingham, West Midlands, B15 2TH, United Kingdom

RECRUITING

Related Publications (2)

  • Bowen DJ, Kreuter M, Spring B, Cofta-Woerpel L, Linnan L, Weiner D, Bakken S, Kaplan CP, Squiers L, Fabrizio C, Fernandez M. How we design feasibility studies. Am J Prev Med. 2009 May;36(5):452-7. doi: 10.1016/j.amepre.2009.02.002.

    PMID: 19362699BACKGROUND
  • Doody P, Lord JM, Greig CA, Whittaker AC. Assessing the feasibility and impact of specially adapted exercise interventions, aimed at improving the multi-dimensional health and functional capacity of frail geriatric hospital inpatients: protocol for a feasibility study. BMJ Open. 2019 Nov 21;9(11):e031159. doi: 10.1136/bmjopen-2019-031159.

Related Links

MeSH Terms

Conditions

FrailtyMotor Activity

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and SymptomsBehavior

Study Officials

  • Prof. Anna Whittaker

    University of Birmingham

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 21, 2017

First Posted

May 5, 2017

Study Start

September 3, 2018

Primary Completion

August 9, 2019

Study Completion

August 9, 2019

Last Updated

July 26, 2019

Record last verified: 2019-04

Data Sharing

IPD Sharing
Will share

Locations