Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study

NCT03627793 | Unknown

• 1 other identifier: 3.0
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

After the age of 40-45 years muscle mass and function progressively decline, reducing older peoples' abilities to perform tasks of daily living and also increase the risk of falls. It is known that, across the life course, resistance exercise can be of benefit in increasing muscle mass and function, yet how hard the exercise should be performed has received little attention. Current recommendations are for older people to perform exercise at 70% of the maximum they can lift, quite a high intensity that often puts older people off participating. Recent evidence in younger people has suggested that such intensities are not required. The investigators aim to determine the feasibility of a study to investigate recruitment and adherence of older people to a study of exercise training at different intensities.

Conditions

Frail Elderly Syndrome

Keywords

frailty; exercise; resistance training; strength; older adults

Outcome Measures

Primary Outcomes (4)

• Number of training sessions attended

  Expressed as a percentage of number of sessions attended

  8 weeks

• Compliance with protocol

  Expressed as a percentage of number of sessions where training protocol was adhered to

  8 weeks

• Number of treatment-related adverse events as assessed by CTCAE v4.0

  Number of adverse events that could be attributed to the intervention

  8 weeks

• Acceptability of intervention (qualitative)

  focus groups with semi-structured discussion plans will investigate the acceptability of the intervention

  8 weeks

Secondary Outcomes (9)

• Muscle thickness

  8 weeks

• Muscle power

  8 weeks

• Muscle strength

  8 weeks

• Frailty

  8 weeks

• Quality of life

  8 weeks

Study Arms (4)

High load non-frail

ACTIVE COMPARATOR

Non-frail participants who will receive resistance training at 70% of their maximal strength

Other: resistance training

low load non-frail

ACTIVE COMPARATOR

Non-frail participants who will receive resistance training at 30% of their maximal strength

Other: resistance training

high load frail

EXPERIMENTAL

Frail participants who will receive resistance training at 70% of their maximal strength

Other: resistance training

low load frail

EXPERIMENTAL

Frail participants who will receive resistance training at 30% of their maximal strength

Other: resistance training

Interventions

resistance training OTHER

Moving muscles against loads with the purpose of increasing strength.

High load non-frail; high load frail; low load frail; low load non-frail

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Non-frail - Over 65 years of age Frail - Over 65 years of age, Three or more of the following criteria: \>10lbs of weight loss unintentionally in previous year; grip strength in lowest 20% (by sex and BMI); self-reported exhaustion; walking time for 15 feet in slowest 20% (by sex and height); physical activity in the lowest 20%.

You may not qualify if:

• Non-frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.
• Frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.

Sponsors & Collaborators

• University of Glasgow: lead
• NHS Greater Glasgow and Clyde: collaborator

Study Sites (1)

Glasgow Royal Infirmary

Glasgow, United Kingdom

RECRUITING

MeSH Terms

Conditions

Frailty; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Evan Campbell, PhD

  Univeristy of Glasgow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Evan Campbell, PhD

CONTACT

0141 330 3076; campbell.evan@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Associate

Model Details: RCT

Study Record Dates

• First Submitted: August 2, 2018
• First Posted: August 13, 2018
• Study Start: August 21, 2018
• Primary Completion: November 29, 2019
• Study Completion: November 29, 2019
• Last Updated: October 11, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)