Cognitive Behavioural Therapy for Children With Autism Spectrum Disorder and Obsessive Compulsive Behaviour

NCT03123146 | Completed

• 1 other identifier: 09-066-VAUSE
• Study Type: interventional
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals with high functioning autism spectrum disorder (ASD) frequently experience obsessions and/or compulsions that are similar to those specified in Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for obsessive compulsive disorder (OCD). However, little research exists on effective interventions for OCD symptoms (referred to as OCBs) in ASD. In a randomized controlled trial, a manualized functional behavior-based cognitive-behavior therapy (Fb-CBT) consisting of traditional CBT components (psychoeducation and mapping, cognitive-behavioral skills training, exposure, and response prevention) as well as function-based behavioral assessment will be evaluated. Participants will be assigned randomly to Fb-CBT or treatment as usual (TAU). Primary and secondary outcome measures will be used to evaluate the efficacy of the treatment, and will be administered at pre and post-intervention as well as six month follow-up.

Conditions

Autism Spectrum Disorder; Obsessive-Compulsive Behavior

Keywords

Cognitive Behavioral Therapy

Outcome Measures

Primary Outcomes (2)

• Change in Repetitive Behavior Scale (RBS_SCR)

  The RBS is a 43-item parent rating measure of repetitive behavior. It is comprised of a four-point Likert scale ranging from (0) behavior does not occur, to (3) behavior occurs and is a severe problem . The RBS\_SCR scale specifically focusses on the assessment of sameness, compulsive, and ritualistic behaviors

  Assessment occurred at baseline and 2 weeks following end of treatment, as well as at follow-up (6 months following the cessation of treatment)

• Change in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS)

  A 10-item, semi-structured interview used to assess symptom severity for children ages 6 through 17 years. Each item is rated on a 5-point ordinal scale from 0 (none) to 4 (extreme)' For the purpose of this study, only the 5-item Compulsion score was used pre and post-treatment.

  Assessment occurred at baseline and 2 weeks following end of treatment

Secondary Outcomes (3)

• Change in Repetitive Behavior Scale 100 (RBS_100)

  Assessment occurred at baseline and 2 weeks following the end of treatment, as well as at follow-up (6 months following the cessation of treatment)

• Change in The child Obsessive-Compulsive Impact Scale-Revised (COIS-R)

  Assessment occurred at baseline and 2-weeks following the end of treatment, as well as at follow-up (6 months following the cessation of treatment)

• Parent OCB Rating Scale.

  Scale was completed by parents at baseline, each day throughout the 9-week treatment period, and at follow-up (6 months following the cessation of treatment)

Study Arms (2)

Fb-Cognitive Behavioral Therapy

EXPERIMENTAL

Functional Behavior-Based Cognitive Behavioral Therapy: Group activities, individual work in parent-child dyads, group parent training, and social skills exercises.

Behavioral: Functional Behavior-Based Cognitive Behavioral Therapy

Treatment as Usual (TAU)

NO INTERVENTION

Children assigned to this condition received "usual care," meaning that they could continue with any services. This group acted as a control group whereby access to intervention was patient-directed.

Interventions

Functional Behavior-Based Cognitive Behavioral Therapy BEHAVIORAL

Fb-CBT involved nine 2-hour weekly sessions with three to four children in each group and two therapists. Therapy consisted of group activities, individual work in parent-child dyads, group parent training, and social skills exercises.

Fb-Cognitive Behavioral Therapy

Eligibility Criteria

• Age: 7 Years - 13 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Previous diagnosis of ASD
• Presence of OCBs as defined by Sameness, Ritualistic and Compulsive subscales on the RBS-R
• a Full Scale IQ (WISC-IV; Wechsler, 2004) ≥ 70
• parent indicated no planned change in child medication during the study (unless the physician deemed the change medically necessary)

You may not qualify if:

• participation in treatment for anxiety
• participation in treatment for repetitive behaviour
• participation in treatment for intensive behavioural intervention

Sponsors & Collaborators

• Tricia Vause: lead
• Ontario Mental Health Foundation: collaborator
• Ontario Ministry of Health and Long Term Care: collaborator

Study Sites (1)

Brock University

St. Catharines, Ontario, L2S3A1, Canada

Location

Related Publications (1)

• Vause T, Jaksic H, Neil N, Frijters JC, Jackiewicz G, Feldman M. Functional Behavior-Based Cognitive-Behavioral Therapy for Obsessive Compulsive Behavior in Children with Autism Spectrum Disorder: A Randomized Controlled Trial. J Autism Dev Disord. 2020 Jul;50(7):2375-2388. doi: 10.1007/s10803-018-3772-x.

  PMID: 30293128 DERIVED

MeSH Terms

Conditions

Autism Spectrum Disorder; Compulsive Behavior

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Impulsive Behavior; Behavior

Study Officials

• Tricia Vause, PhD

  Brock University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 13, 2017
• First Posted: April 21, 2017
• Study Start: June 1, 2010
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2014
• Last Updated: April 21, 2017

Record last verified: 2017-04

Locations

CA (1)