Upstate New York Infant Development Screening Program

NCT03106493 | Completed

• 1 other identifier: HHSN275201400013C
• Study Type: observational
• Target: 6,171
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of the Upstate KIDS Study is to track the growth, development and long-term health of children given the increasing use of infertility treatment, occurrence of maternal obesity and pregnancy complications, and rising maternal age at birth.

Conditions

Obesity; Blood Pressure; Motor Delay; Developmental Delay; Asthma; Allergies

Outcome Measures

Primary Outcomes (1)

• Blood Pressure

  Measurement of blood pressure

  Through age 9 years

Secondary Outcomes (1)

• Motor milestone development

  4-24 months

Other Outcomes (1)

• Breastfeeding information

  4-12 months

Study Arms (3)

Primary

Singletons and 1 twin of each pair

Other: None (observational)

Secondary

Twin sibling of children enrolled in primary cohort

Other: None (observational)

Tertiary

Higher order multiples and siblings

Other: None (observational)

Interventions

None (observational) OTHER

None (observational)

Primary; Secondary; Tertiary

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Exposure enriched cohort as described: Buck Louis GM, Hediger ML, Bell EM, Kus CA, Sundaram R, McLain AC, Yeung E, Hills EA, Thoma ME, Druschel CM. Methodology for Establishing a Population-Based Birth Cohort Focusing on Couple Fertility and Children's Development, the Upstate KIDS Study. Paediatric and Perinatal Epidemiology. 2014 May;28(3):191-202.

You may qualify if:

• Mothers delivering a live birth in New York State (excluding New York City).

You may not qualify if:

• Refused follow-up

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): lead
• New York State Department of Health: collaborator
• University at Albany: collaborator

Related Publications (9)

• Buck Louis GM, Hediger ML, Bell EM, Kus CA, Sundaram R, McLain AC, Yeung E, Hills EA, Thoma ME, Druschel CM. Methodology for establishing a population-based birth cohort focusing on couple fertility and children's development, the Upstate KIDS Study. Paediatr Perinat Epidemiol. 2014 May;28(3):191-202. doi: 10.1111/ppe.12121. Epub 2014 Mar 25.

  PMID: 24665916 BACKGROUND

• Andersen NJ, Mondal TK, Preissler MT, Freed BM, Stockinger S, Bell E, Druschel C, Louis GM, Lawrence DA. Detection of immunoglobulin isotypes from dried blood spots. J Immunol Methods. 2014 Feb;404:24-32. doi: 10.1016/j.jim.2013.12.001. Epub 2013 Dec 13.

  PMID: 24333851 BACKGROUND

• Buck Louis GM, Druschel C, Bell E, Stern JE, Luke B, McLain A, Sundaram R, Yeung E. Use of assisted reproductive technology treatment as reported by mothers in comparison with registry data: the Upstate KIDS Study. Fertil Steril. 2015 Jun;103(6):1461-8. doi: 10.1016/j.fertnstert.2015.02.033. Epub 2015 Mar 23.

  PMID: 25813287 BACKGROUND

• Yeung EH, Sundaram R, Bell EM, Druschel C, Kus C, Ghassabian A, Bello S, Xie Y, Buck Louis GM. Examining Infertility Treatment and Early Childhood Development in the Upstate KIDS Study. JAMA Pediatr. 2016 Mar;170(3):251-8. doi: 10.1001/jamapediatrics.2015.4164.

  PMID: 26746435 BACKGROUND

• Yeung EH, Sundaram R, Bell EM, Druschel C, Kus C, Xie Y, Buck Louis GM. Infertility treatment and children's longitudinal growth between birth and 3 years of age. Hum Reprod. 2016 Jul;31(7):1621-8. doi: 10.1093/humrep/dew106. Epub 2016 May 10.

  PMID: 27165624 BACKGROUND

• Clayton PK, Putnick DL, Trees IR, Robinson SL, O'Connor TG, Tyris JN, Yeung EH. Age of Juice Introduction and Cardiometabolic Outcomes in Middle Childhood. J Nutr. 2024 Aug;154(8):2514-2523. doi: 10.1016/j.tjnut.2024.06.014. Epub 2024 Jun 26.

  PMID: 38936550 DERIVED

• Polinski KJ, Robinson SL, Putnick DL, Sundaram R, Ghassabian A, Joseph P, Gomez-Lobo V, Bell EM, Yeung EH. Maternal self-reported polycystic ovary syndrome with offspring and maternal cardiometabolic outcomes. Hum Reprod. 2024 Jan 5;39(1):232-239. doi: 10.1093/humrep/dead227.

  PMID: 37935839 DERIVED

• Yeung EH, Mendola P, Sundaram R, Lin TC, Broadney MM, Putnick DL, Robinson SL, Polinski KJ, Wactawski-Wende J, Ghassabian A, O'Connor TG, Gore-Langton RE, Stern JE, Bell E. Conception by fertility treatment and cardiometabolic risk in middle childhood. Fertil Steril. 2022 Aug;118(2):349-359. doi: 10.1016/j.fertnstert.2022.04.030. Epub 2022 Jun 10.

  PMID: 35697532 DERIVED

• Michels KA, Ghassabian A, Mumford SL, Sundaram R, Bell EM, Bello SC, Yeung EH. Breastfeeding and motor development in term and preterm infants in a longitudinal US cohort. Am J Clin Nutr. 2017 Dec;106(6):1456-1462. doi: 10.3945/ajcn.116.144279. Epub 2017 Nov 1.

  PMID: 29092884 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Plasma, urine, saliva (in subgroup under ongoing future work)

MeSH Terms

Conditions

Obesity; Psychomotor Disorders; Learning Disabilities; Asthma; Hypersensitivity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Communication Disorders; Neurodevelopmental Disorders; Mental Disorders; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 4, 2017
• First Posted: April 10, 2017
• Study Start: July 1, 2008
• Primary Completion: November 1, 2019
• Study Completion: November 1, 2019
• Last Updated: March 3, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will share