Acute Kidney Injury in Adult Patients Supported by VA-ECMO
AKI-ECMO
Risk Factors and Prognosis of Acute Kidney Injury in Peri Operative Cardiac Surgery Adult Patients Supported by VA-ECMO
1 other identifier
observational
347
1 country
1
Brief Summary
Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane Oxygenation (VA-ECMO). Acute Kidney Injury is a frequent complication in this population and negatively impacts the survival. We aimed to determine whether the timing of ECMO implantation influence the renal prognosis of these patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 5, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 5, 2019
CompletedFirst Submitted
Initial submission to the registry
September 5, 2019
CompletedFirst Posted
Study publicly available on registry
September 9, 2019
CompletedSeptember 13, 2023
September 1, 2023
3 years
September 5, 2019
September 11, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Occurrence of a stage 3 AKI
Number of Participants with Stage 3 Acute Kidney Injury according to the Kidney Disease: Improving Global Outcomes (KDIGO) group
Day 10 after ECMO implantation
Secondary Outcomes (2)
Mortality at Day 30
Day 30 after ECMO implantation
Mortality at 6 months
6 months after ECMO implantation
Study Arms (3)
Group 1
Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + with KDIGO stage 3 AKI
Group 2
Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + without KDIGO stage 3 AKI and alive at D10
Group 3
Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + died before D10 without KDIGO stage 3 AKI
Interventions
Eligibility Criteria
All patients admitted in the Surgical Intensive Care Unit of the Cardiology Institute of La Pitié Salpêtrière University Hospital (Paris, France) between January 2013 and December 2016.
You may qualify if:
- All patients admitted in post-operative of cardiac surgery
- Assisted by VA-ECMO
You may not qualify if:
- Chronic hemodialysis
- Death occurring within the first 48 hours of VA-ECMO implantation
- Multiple VA-ECMO during the same hospitalization.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Dr Adrien Bouglé
Paris, 75013, France
Related Publications (1)
Lepere V, Duceau B, Lebreton G, Bombled C, Dujardin O, Boccara L, Charfeddine A, Amour J, Hajage D, Bougle A. Risk Factors for Developing Severe Acute Kidney Injury in Adult Patients With Refractory Postcardiotomy Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. Crit Care Med. 2020 Aug;48(8):e715-e721. doi: 10.1097/CCM.0000000000004433.
PMID: 32697513DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head of Surgical Intensive Care Unit
Study Record Dates
First Submitted
September 5, 2019
First Posted
September 9, 2019
Study Start
May 1, 2016
Primary Completion
May 5, 2019
Study Completion
July 5, 2019
Last Updated
September 13, 2023
Record last verified: 2023-09
Data Sharing
- IPD Sharing
- Will not share