Effect of an Antioxidant-rich Diet During Moderate Altitude Training

NCT03088891 | Completed

• 1 other identifier: ALTAX
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 2

Brief Summary

Athletes, especially in endurance sports, are at increased risk of oxidative stress and inflammation-related diseases and injuries. The production of reactive oxygen and nitrogen species (RONS) and inflammatory markers increase during exercise and especially during altitude training. Antioxidant supplementation is commonly used among athletes in the belief that it prevents oxidative stress and oxidative damage. A transient increase of RONS is however necessary to activate signaling cascades initiating training adaptation. Antioxidant supplementation has been shown to inhibit the exercise effects in several independent studies, possibly by interfering/reducing the signal cascades initiated by RONS. However, it is unknown whether a high intake of antioxidant rich foods can affect the amount of RONS, inflammation markers and/or training adaptation. The investigators want to examine whether an increased intake of natural antioxidants in the form of antioxidant-rich foods fruits, vegetables and berries, in line with the official Norwegian dietary advice can affect antioxidant status, immune function and training adaptation associated with altitude training in Norwegian elite athletes.

Conditions

Oxidative Stress; Adaptation Reaction; Inflammation

Keywords

altitude training; antioxidants; oxidative stress; elite athletes; inflammation; diet

Outcome Measures

Primary Outcomes (3)

• Percent change in performance (sport specific tests will be aggregated to one outcome by the use of percent change)

  Cycling: 10 000 m on a bike roller; Rowing: 2000 meter on Concept2-apparatus; Paddling: 1000 meter Concept2-apparatus; Swimming: 200 meter

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

• Training adaptation

  change in Vo2-max

  Measured one week before, and one week after the moderate altitude training camp

• Training adaptation for swimmers

  For swimming only: 100 meter max speed

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

Secondary Outcomes (19)

• Change in biomarkers of inflammation

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

• change in lean body mass

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

• Bone mineral density

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

• change in fat mass

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

• change in body composition

  Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp

Study Arms (2)

Antioxidant-rich snacks

EXPERIMENTAL

The participants received antioxidant-rich snacks every day during 21 days of moderate altitude training (2300 meters above sea level). The snack included fruits and vegetable smoothies, dark chocolate, walnuts, dried fruits and berries.

Other: Antioxidant-rich snacks

Control snacks

PLACEBO COMPARATOR

The participants received antioxidant-depleted snacks every day during 21 days of moderate altitude training (2300 meters above sea level). The snack included milkshake, and other milk-based drinks, biscuits (both sweet and salty), white chocolate.

Other: Control snacks

Interventions

Antioxidant-rich snacks OTHER

Bama Smoothies (Bama, Oslo, Norway), Freia Premium Dark Chocolate (Freia, Oslo, Norway), Walnuts (Eldorado, Norway), Dried fruits and berries (Cranberries, Gojiberries, apricots)(Bama, Oslo, Norway and Rema 1000, Norway)

Antioxidant-rich snacks

Control snacks OTHER

Milkshake (Tine, Oslo, Norway), YT restitusjonsdrikk (Tine, Oslo, Norway), Bixit (Sætre, Oslo, Norway), Ritz (Mondelez, Oslo, Norway), White chololate (Freia, Oslo, Norway)

Control snacks

Eligibility Criteria

• Age: 16 Years - 42 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• National team athletes, summer endurance sports

You may not qualify if:

• Allergies in conflict with the intervention foods
• Use of medication that could affect training and performance
• Injuries that could affect training and performance

Sponsors & Collaborators

• University of Oslo: lead
• Norwegian School of Sport Sciences: collaborator
• Norwegian Olympic Federation, Oslo, Norway: collaborator

Study Sites (2)

University of Oslo

Oslo, 0316, Norway

Location

Norwegian Olympic Federation

Oslo, Norway

Location

Related Publications (1)

• Koivisto-Mork AE, Paur I, Paulsen G, Garthe I, Raastad T, Bastani NE, Blomhoff R, Bohn SK. Dietary Adjustments to Altitude Training in Elite Endurance Athletes; Impact of a Randomized Clinical Trial With Antioxidant-Rich Foods. Front Sports Act Living. 2020 Aug 26;2:106. doi: 10.3389/fspor.2020.00106. eCollection 2020.

  PMID: 33345095 DERIVED

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 20, 2016
• First Posted: March 23, 2017
• Study Start: October 1, 2015
• Primary Completion: November 1, 2015
• Study Completion: November 1, 2015
• Last Updated: March 23, 2017

Record last verified: 2017-03

Locations

NO (2)