China Registry of Non-disabling Ischemic Cerebrovascular Events
CR-NICE
1 other identifier
observational
10,000
1 country
44
Brief Summary
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. In order to achieve accurate risk stratification and effective treatments, developing new diagnostic, therapeutic, and prognostic strategies is indispensable. Chinese registry of NICE is a national multi-center prospective study aimed to explore the epidemiology, new biomarkers, risk factors and prognostic models.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2017
Typical duration for all trials
44 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 9, 2017
CompletedFirst Posted
Study publicly available on registry
March 14, 2017
CompletedStudy Start
First participant enrolled
June 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2020
CompletedMay 11, 2017
May 1, 2017
1.7 years
March 9, 2017
May 9, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
Death
Death from any cause
3 months
Death
Death from any cause
6 months
Death
Death from any cause
12 months
Stroke recurrence
Ischemic stroke
3 months
Stroke recurrence
Ischemic stroke
6 months
Stroke recurrence
Ischemic stroke
12 months
Secondary Outcomes (9)
Hemorrhagic stroke
3 months
Hemorrhagic stroke
6 months
Hemorrhagic stroke
12 months
Cardiovascular disease
3 months
Cardiovascular disease
6 months
- +4 more secondary outcomes
Study Arms (1)
NICE patients
Non-disabling ischemic cerebrovascular events patients indicate patients with transient ischemic attack and minor stroke (National Institute of Health stroke scale, NIHSS≤3).
Interventions
Eligibility Criteria
Adults patients (≥18 years) within 48 hours of onset of a minor stroke (National Institute of Health stroke scale, NIHSS≥3) and TIA.
You may qualify if:
- ≥18 years old
- elapsed time from last episode to registry \<48 hours
You may not qualify if:
- patients who refused to participate in the research, and patients who failed to complete the follow-up protocol.
- patients with malignant tumors, or patients with severe liver or kidney disease, whose life expectancy is less than 1 year.
- patients who received endovascular or thrombolytic therapy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (44)
Chongqing Three Gorges Central Hospital
Chongqing, Chongqing Municipality, 404000, China
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, 361003, China
Jiangmen Central Hospital
Jiangmen, Guangdong, 529000, China
Yuebei People's Hospital
Shaoguan, Guangdong, 512026, China
Shijiazhuang the Third Hospital
Shijiazhuang, Hebei, 050011, China
Xingtai Third Hospital
Xingtai, Hebei, 054000, China
Anyang People's Hospital
Anyang, Henan, 455000, China
The People's Hospital of Hebi
Hebi, Henan, 458000, China
The Second People 's Hospital of Jiaozuo
Jiaozuo, Henan, 454150, China
The Huaihe Hospital of Henan University
Kaifeng, Henan, 475000, China
Luohe Central Hospital
Luohe, Henan, 462000, China
Luoyang Central Hospital Affiliated to Zhengzhou University
Luoyang, Henan, 471000, China
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, 471000, China
Nanyang City Central Hospital
Nanyang, Henan, 473000, China
Nanshi Hospital of Nanyang
Nanyang, Henan, 473065, China
The First People's Hospital of Pingdingshan
Pingdingshan, Henan, 467000, China
People's Hospital of Puyang
Puyang, Henan, 457000, China
Sanmenxia Central Hospital
Sanmenxia, Henan, 472000, China
The First People's Hospital of Shangqiu
Shangqiu, Henan, 476100, China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan, 453000, China
Xinxiang Central Hospital
Xinxiang, Henan, 453000, China
Xinyang Central Hospital
Xinyang, Henan, 464000, China
Xuchang Central Hospital
Xuchang, Henan, 461000, China
The Fifth Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
The Medical Group of Zhengzhou First People's Hospital
Zhengzhou, Henan, 450000, China
People's Hospital of Zhengzhou
Zhengzhou, Henan, 450003, China
Zhoukou Central Hospital
Zhoukou, Henan, 466000, China
Zhumadian Central Hospital
Zhumadian, Henan, 463000, China
Jingmen No.1 People 's Hospital
Jingmen, Hubei, 448000, China
Wuhan NO.1 Hospital
Wuhan, Hubei, 430022, China
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 014010, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
The General Hospital of Shenyang Military
Shenyang, Liaoning, 110840, China
Ankang HospitaL of Traditional Chinese Medicine
Ankang, Shanxi, 725000, China
Fenyang Hospital
Fenyang, Shanxi, 032200, China
Linfen People's Hospital
Linfen, Shanxi, 041000, China
Shanxi Provincial People 's Hospital
Xi'an Shi, Shanxi, 710068, China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, 646000, China
Mianyang Central Hospital
Mianyang, Sichuan, 621000, China
Nanchong Central Hospital
Nanchong, Sichuan, 637000, China
The Institute of Traditional Chinese Medicine of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang, 830000, China
Yan'an Affiliated Hospital to Kunming Medical University
Kunming, Yunnan, 650051, China
The Second Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650101, China
Related Publications (14)
Yaghi S, Rostanski SK, Boehme AK, Martin-Schild S, Samai A, Silver B, Blum CA, Jayaraman MV, Siket MS, Khan M, Furie KL, Elkind MS, Marshall RS, Willey JZ. Imaging Parameters and Recurrent Cerebrovascular Events in Patients With Minor Stroke or Transient Ischemic Attack. JAMA Neurol. 2016 May 1;73(5):572-8. doi: 10.1001/jamaneurol.2015.4906.
PMID: 26998948BACKGROUNDMeng X, Wang Y, Liu L, Pu Y, Zhao X, Wang C, Wang Y. Validation of the ABCD(2)-I score to predict stroke risk after transient ischemic attack. Neurol Res. 2011 Jun;33(5):482-6. doi: 10.1179/016164111X13007856084043.
PMID: 21669116BACKGROUNDGiles MF, Rothwell PM. Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol. 2007 Dec;6(12):1063-72. doi: 10.1016/S1474-4422(07)70274-0. Epub 2007 Nov 13.
PMID: 17993293BACKGROUNDWu CM, McLaughlin K, Lorenzetti DL, Hill MD, Manns BJ, Ghali WA. Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis. Arch Intern Med. 2007 Dec 10;167(22):2417-22. doi: 10.1001/archinte.167.22.2417.
PMID: 18071162BACKGROUNDWang Y, Zhao X, Jiang Y, Li H, Wang L, Johnston SC, Liu L, Wong KS, Wang C, Pan Y, Jing J, Xu J, Meng X, Zhang M, Li Y, Zhou Y, Zhao W, Wang Y. Prevalence, knowledge, and treatment of transient ischemic attacks in China. Neurology. 2015 Jun 9;84(23):2354-61. doi: 10.1212/WNL.0000000000001665. Epub 2015 May 8.
PMID: 25957333BACKGROUNDWang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, Zhou Y, Zhao X, Wang C, Liu L, Nguyen-Huynh MN, Claiborne Johnston S, Wong L, Li H; China National Stroke Registry Investigators. The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke. 2011 Aug;6(4):355-61. doi: 10.1111/j.1747-4949.2011.00584.x. Epub 2011 Feb 17.
PMID: 21609414BACKGROUNDWang Y, Li Z, Xian Y, Zhao X, Li H, Shen H, Wang C, Liu L, Wang C, Pan Y, Wang D, Prvu Bettger J, Fonarow GC, Schwamm LH, Smith SC Jr, Peterson ED, Wang Y; GOLDEN BRIDGE-AIS investigators. Rationale and design of a cluster-randomized multifaceted intervention trial to improve stroke care quality in China: The GOLDEN BRIDGE-Acute Ischemic Stroke. Am Heart J. 2015 Jun;169(6):767-774.e2. doi: 10.1016/j.ahj.2015.03.008. Epub 2015 Mar 26.
PMID: 26027613BACKGROUNDWardlaw JM, Brazzelli M, Chappell FM, Miranda H, Shuler K, Sandercock PA, Dennis MS. ABCD2 score and secondary stroke prevention: meta-analysis and effect per 1,000 patients triaged. Neurology. 2015 Jul 28;85(4):373-80. doi: 10.1212/WNL.0000000000001780. Epub 2015 Jul 1.
PMID: 26136519BACKGROUNDSong B, Fang H, Zhao L, Gao Y, Tan S, Lu J, Sun S, Chandra A, Wang R, Xu Y. Validation of the ABCD3-I score to predict stroke risk after transient ischemic attack. Stroke. 2013 May;44(5):1244-8. doi: 10.1161/STROKEAHA.113.000969. Epub 2013 Mar 26.
PMID: 23532014BACKGROUNDWang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke. 2014 Mar;45(3):663-9. doi: 10.1161/STROKEAHA.113.003508. Epub 2014 Jan 30.
PMID: 24481975BACKGROUNDSuri MF, Qiao Y, Ma X, Guallar E, Zhou J, Zhang Y, Liu L, Chu H, Qureshi AI, Alonso A, Folsom AR, Wasserman BA. Prevalence of Intracranial Atherosclerotic Stenosis Using High-Resolution Magnetic Resonance Angiography in the General Population: The Atherosclerosis Risk in Communities Study. Stroke. 2016 May;47(5):1187-93. doi: 10.1161/STROKEAHA.115.011292. Epub 2016 Apr 7.
PMID: 27056984BACKGROUNDAmarenco P, Lavallee PC, Labreuche J, Albers GW, Bornstein NM, Canhao P, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Molina C, Rothwell PM, Sissani L, Skoloudik D, Steg PG, Touboul PJ, Uchiyama S, Vicaut E, Wong LK; TIAregistry.org Investigators. One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke. N Engl J Med. 2016 Apr 21;374(16):1533-42. doi: 10.1056/NEJMoa1412981.
PMID: 27096581BACKGROUNDWang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC; CHANCE Investigators. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013 Jul 4;369(1):11-9. doi: 10.1056/NEJMoa1215340. Epub 2013 Jun 26.
PMID: 23803136BACKGROUNDWang Y, Pan Y, Zhao X, Li H, Wang D, Johnston SC, Liu L, Meng X, Wang A, Wang C, Wang Y; CHANCE Investigators. Clopidogrel With Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) Trial: One-Year Outcomes. Circulation. 2015 Jul 7;132(1):40-6. doi: 10.1161/CIRCULATIONAHA.114.014791. Epub 2015 May 8.
PMID: 25957224BACKGROUND
Biospecimen
The faecal samples, plasma, serum and whole blood are retained to establish the biological samples library of NICE.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yuming Xu, MD, PhD
The First Affiliated Hospital of Zhengzhou University
- PRINCIPAL INVESTIGATOR
Yilong Wang, MD, PhD
Beijing Tiantan Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 12 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 9, 2017
First Posted
March 14, 2017
Study Start
June 1, 2017
Primary Completion
February 1, 2019
Study Completion
February 1, 2020
Last Updated
May 11, 2017
Record last verified: 2017-05