Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
CHANCE-2
1 other identifier
interventional
6,412
1 country
214
Brief Summary
The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 stroke
Started Sep 2019
Shorter than P25 for phase_3 stroke
214 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 8, 2019
CompletedFirst Posted
Study publicly available on registry
September 6, 2019
CompletedStudy Start
First participant enrolled
September 23, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 24, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2021
CompletedDecember 2, 2021
November 1, 2021
1.8 years
July 8, 2019
November 30, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Any new stroke events (ischemic stroke or hemorrhagic stroke) within 3 months
The aim is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
3 months after randomization
Secondary Outcomes (8)
Any new stroke events within 30 days and 1 year
30 days and 1 year after randomization
New clinical vascular events including stroke, TIA, myocardial infarction, and vascular deaths within 3 months and 1 year
3 months and 1 year after randomization
New ischemic stroke within 3 months and 1 year
3 months and 1 year after randomization
Disabling stroke (Modified Rankin Scale score, mRS>1) at 3 months and 1 year
3 months and 1 year after randomization
Incidence and severity of recurrent stroke and TIA during follow-up to 3 months and 1-year
3 months and 1 year after randomization
- +3 more secondary outcomes
Other Outcomes (6)
Moderate and severe bleeding events according to the GUSTO criteria
3 months after randomization
Moderate and severe bleeding events according to the GUSTO criteria
1 year after randomization
All bleeding events
3 months and 1 year after randomization
- +3 more other outcomes
Study Arms (2)
Ticagrelor plus Aspirin Group
EXPERIMENTALTicagrelor of loading dosing of 180mg followed by 90mg bid for 3 months plus aspirin of loading dose of 75-300mg followed by 75mg daily for 21 days
Clopidogrel plus Aspirin Group
ACTIVE COMPARATORClopidogrel of loading dosing of 300mg followed by 75mg daily for 3 months plus aspirin loading dose of 75-300mg followed by 75mg daily for 21 days
Interventions
Day of randomization: Day1:Ticagrelor 180mg; placebo of clopidogrel 300mg; aspirin 75-300mg (open label) Day2-21st: Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg; aspirin 75mg (open label) Day 22nd-3 months:Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg
Day of randomization: Day 1: Clopidogrel 300mg; placebo of ticagrelor 180mg; aspirin 75-300mg (open label) Day2-21st: Clopidogrel 75mg/day; placebo of ticagrelor 90mg bid/day; aspirin 75mg (open label) Day 22nd-3 months:Clopidogrel 75mg; placebo of ticagrelor 90mg bid/day
Eligibility Criteria
You may qualify if:
- years or older than 40 years；
- Acute cerebral ischemic event due to：
- Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization)or，
- TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization)；
- Can be treated with study drug within 24 hours of symptoms onset\*(\*Symptom onset is defined by the "last seen normal" principle)；
- CYP2C19 loss-of-function allele carriers；
- Informed consent signed.
You may not qualify if:
- Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.
- Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
- Iatrogenic causes (angioplasty or surgery) of minor stroke or TIA.
- Preceding moderate or severe dependency (modified Rankin scale \[mRS\] score 3-5).
- Contraindication to clopidogrel, ticagrelor or aspirin
- Known allergy
- Severe renal (creatinine exceeding 1.5 times of the upper limit of normal range) or hepatic (ALT or AST \> twice the upper limit of normal range) insufficiency
- Severe cardiac failure (NYHA level: III to IV)
- History of hemostatic disorder or systemic bleeding
- History of thrombocytopenia or neutropenia
- History of drug-induced hematologic disorder or hepatic dysfunction
- Low white blood cell (\<2×109/L) or platelet count (\<100×109/L)
- Hematocrit (HCT) \<30%
- Clear indication for anticoagulation (presumed cardiac source of embolus, e.g., atrial fibrillation, prosthetic cardiac valves known or suspected endocarditis)
- History of intracranial hemorrhage or amyloid angiopathy
- +17 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (214)
Anqing Municipal Hospital
Anqing, Anhui, 246003, China
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, 233004, China
Beijing Chaoyang Hospital, Capital MedicalUniversity（west Hospital）
Beijing, Beijing Municipality, 100043, China
Beijing Tian tan Hospital
Beijing, Beijing Municipality, 100070, China
Beijing Shunyi Airport Hospital
Beijing, Beijing Municipality, 101318, China
The First Hospital of Fangshan District
Beijing, Beijing Municipality, 102488, China
Beijing Coal Group Hospital
Beijing, Beijing Municipality, China
Peking University Third Hospital
Beijing, Beijing Municipality, China
Chongqing People's Hospital
Chongqing, Chongqing Municipality, 400010, China
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400010, China
Chongqing Sanbo Chang 'an Hospital
Chongqing, Chongqing Municipality, 400023, China
Daping Hospital of Army Military Medical University
Chongqing, Chongqing Municipality, 400042, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400060, China
Chongqing Fifth People's Hospital
Chongqing, Chongqing Municipality, 400062, China
The Third Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 401120, China
People's Hospital of Rongchang District, Chongqing,
Chongqing, Chongqing Municipality, 402460, China
Chongqing Three Gorges Central Hospital
Chongqing, Chongqing Municipality, 404000, China
Chongqing Kaizhou District People's Hospital
Chongqing, Chongqing Municipality, 405400, China
Chongqing Fuling Central Hospital
Chongqing, Chongqing Municipality, 408000, China
Chongqing Nanchuan District People's Hospital
Chongqing, Chongqing Municipality, 408400, China
Xiushan Tujia and Miao Autonomous County People's Hospital
Chongqing, Chongqing Municipality, 409900, China
The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine
Fuzhou, Fujian, 350025, China
Fuzhou Second Hospital
Fuzhou, Fujian, China
Sanming First Hospital Affiliated to Fujian Medical University
Sanming, Fujian, 100043, China
Wuwei People's Hospital
Wuwei, Gansu, 733000, China
Zhangye People's Hospital Affiliated to Hexi College
Zhangye, Gansu, 734000, China
Dongguan People's Hospital
Dongguan, Guangdong, 523000, China
The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510260, China
Nanfang Hospital Of Southern Medical University
Guangzhou, Guangdong, 510515, China
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510632, China
The first Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, 515041, China
Guiyang Second People's Hospital
Guiyang, Guizhou, 550000, China
Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, 550004, China
Hainan West Central Hospital
Danzhou, Hainan, 571799, China
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, 570102, China
Affiliated Hospital of Hebei Medical University
Baoding, Hebei, 071000, China
Affiliated Hospital of Hebei University
Baoding, Hebei, 071000, China
The Affiliated Hospital of Chengde Medical College
Chengde, Hebei, 067000, China
Hejian People's Hospital
Hejian, Hebei, 062450, China
HaLixun InternationalPeace Hospital
Hengshui, Hebei, 053000, China
Hengshui fourth People Hospital（Department of Neurology ward 2）
Hengshui, Hebei, 053000, China
The Fourth People's Hospital of Hengshui City（Department of Neurology ward 1）
Hengshui, Hebei, 053000, China
The Second Hospitalof Hebei Medical University
Shijiazhuang, Hebei, 050000, China
The First Affiliated Hospital of Hebei North University
Zhangjiakou, Hebei, 75000, China
Second Central Hospital of Baoding
Zhuozhou, Hebei, 072750, China
Daqing Oilfield Gengeal Hospital
Daqing, Heilongjiang, 163001, China
Daqing People's Hospital
Daqing, Heilongjiang, 163361, China
The First Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
The Second Hospital of Harbin Medical University（Department of Neurology ward 1）
Harbin, Heilongjiang, 150086, China
The Second Hospital of Harbin Medical University（Department of Neurology ward ）
Harbin, Heilongjiang, 150086, China
The First Affiliated Hospital of Jiamusi University
Jiamusi, Heilongjiang, 154002, China
Hongqi Hospital affiliated to Mudanjiang Medical University
Mudanjiang, Heilongjiang, 157000, China
Qiqihar Rongjian Institute of Stroke Prevention and Treatment
Qiqihar, Heilongjiang, China
Anyang People's Hospital
Anyang, Henan, 455000, China
Changge People's Hospital
Jianshe, Henan, 461500, China
Xiuwu County People's Hospital
Jiaozuo, Henan, 454350, China
Jiyuan People's Hospital
Jiyuan, Henan, 459000, China
Kaifeng Central Hospital
Kaifeng, Henan, 475000, China
weishi county Central Hospital
Kaifeng, Henan, 475500, China
Luohe Central Hospital
Luohe, Henan, 462000, China
Luoyang Central Hospital
Luoyang, Henan, 471000, China
The first Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, 471000, China
The Second Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, 471000, China
Luoyang New District People's Hospital
Luoyang, Henan, 471023, China
Pingdingshan First People's Hospital
Pingdingshan, Henan, 467000, China
Sanmenxia Central Hospital
Sanmenxia, Henan, 472000, China
Shangqiu Fourth People's Hospital
Shangqiu, Henan, 476000, China
Suixian county Hospital of Traditional Chinese Medicine
Shangqiu, Henan, 476900, China
Xingyang People's Hospital
Xingyang, Henan, 450100, China
The first Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan, 453100, China
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Zhengzhou, Henan, 450000, China
Gongyi People's Hospital
Zhengzhou, Henan, 451200, China
Zhoukou Yongshan Hospital
Zhoukou, Henan, 461300, China
Zhumadian Hospital of Traditional Chinese Medicine
Zhumadian, Henan, 463000, China
Wuhan No.1 Hospital
Wuhan, Hubei, 430000, China
The Central Hospital of Wuhan
Wuhan, Hubei, 430014, China
First hospital of Changsha city
Changsha, Hunan, 410005, China
Chenzhou First People's Hospital
Chenzhou, Hunan, 423000, China
Fourth People's Hospital of Chenzhou
Chenzhou, Hunan, 423000, China
The First Affiliated Hospital of Nanhua University
Hengyang, Hunan, 421001, China
Loudi City Central Hospital
Loudi, Hunan, 417000, China
shaoyang Central Hospital
Shaoyang, Hunan, China
Xiangtan Central Hospital
Xiangtan, Hunan, 411100, China
Yueyang Second People's Hospital
Yueyang, Hunan, 414000, China
The first Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 014010, China
Baotou CentralHospital
Baotou, Inner Mongolia, 014040, China
The second Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 14030, China
Wuyuan County People's Hospital
Bayan Nur, Inner Mongolia, 15100, China
Hulun Buir People's Hospital
Buri, Inner Mongolia, 21000, China
Chifeng City Hospital
Chifeng, Inner Mongolia, 024000, China
Affiliated Hospital of Chifeng University
Chifeng, Inner Mongolia, 024005, China
Inner Mongolia People's Hospital
Hohhot, Inner Mongolia, 010017, China
Inner Mongolia International Mongolian Hospital
Hohhot, Inner Mongolia, 010069, China
Huaian Hospital of Traditional Chinese Medicine
Huai'an, Jiangsu, 223001, China
Lianshui County People's Hospital
Huai'an, Jiangsu, 223400, China
The Second People's Hospital of Lianyungang
Lianyungang, Jiangsu, 222023, China
Nanjing Jiangning Hospital
Nanjing, Jiangsu, 210000, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, 210003, China
Nanjing Gulou Hospital
Nanjing, Jiangsu, 210008, China
BenQ Hospital affiliated to Nanjing Medical University
Nanjing, Jiangsu, 210019, China
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Nanjing, Jiangsu, 210029, China
Nanjing Brain Hospital
Nanjing, Jiangsu, 210029, China
The Fourth Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, 210031, China
Nanjing Jiangbei People's Hospital
Nanjing, Jiangsu, 210048, China
Nanjing Gaochun People's Hospital
Nanjing, Jiangsu, 211300, China
Nantong 6th People's Hospital
Nantong, Jiangsu, 226000, China
Nantong Hospital of Traditional Chinese Medicine
Nantong, Jiangsu, 226000, China
The Third People's Hospital in Tongzhou District, Nantong
Nantong, Jiangsu, 226000, China
Affiliated Hospital of Nantong University
Nantong, Jiangsu, 226001, China
Nantong First People's Hospital
Nantong, Jiangsu, 226001, China
Nantong Second People's Hospital
Nantong, Jiangsu, 226002, China
Nantong Fourth People's Hospital
Nantong, Jiangsu, 226005, China
Nantong Third People's Hospital
Nantong, Jiangsu, 22600, China
Tongzhou District People's Hospital of Nantong City
Nantong, Jiangsu, 226300, China
Rudong County People's Hospital
Nantong, Jiangsu, 226400, China
Rugao People's Hospital
Nantong, Jiangsu, 226500, China
Hai 'an People's Hospital
Nantong, Jiangsu, 226600, China
Tongzhou District 8th People's Hospital of Nantong City
Nantong, Jiangsu, China
Siyang County People's Hospital
Suqian, Jiangsu, 223700, China
Siyang Kangda Hospital
Suqian, Jiangsu, 223700, China
Suqian People's Hospital
Suqian, Jiangsu, 223800, China
Suzhou Municipal Hospital
Suzhou, Jiangsu, 215000, China
The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215004, China
Taizhou People's Hospital
Taizhou, Jiangsu, 225300, China
Xinghua People's Hospital
Taizhou, Jiangsu, 225700, China
Wuxi People's Hospital
Wuxi, Jiangsu, 214000, China
Affiliated Hospital of Jiangnan University
Wuxi, Jiangsu, 214041, China
Yixing People's Hospital
Wuxi, Jiangsu, 214200, China
Jiangyin People's Hospital
Wuxi, Jiangsu, 214400, China
xuzhou Central Hospital
Xuzhou, Jiangsu, 221000, China
Xuzhou coal mining group General Hospital
Xuzhou, Jiangsu, 221000, China
Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 1）
Xuzhou, Jiangsu, 221002, China
Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 2）
Xuzhou, Jiangsu, 221002, China
Subei People's Hospital of Jiangsu province
Yangzhou, Jiangsu, 225009, China
Affiliated Hospital of Yangzhou University
Yangzhou, Jiangsu, 225012, China
The fourth peoples hospital of zhenjiang city
Zhenjiang, Jiangsu, 212001, China
Ganzhou city people's Hospital
Ganzhou, Jiangxi, 341000, China
The First People's Hospital of Jingdehzne City
Jingdezhen, Jiangxi, 333000, China
Affiliated Hospital of Jiujiang College
Jiujiang, Jiangxi, 332000, China
Jiujiang first people's Hospital
Jiujiang, Jiangxi, 332000, China
First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330000, China
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, 330006, China
Shangrao City People's Hospital
Shangrao, Jiangxi, China
Sino-Japanese Friendship Hospital Of Jilin University
Changchun, Jilin, 130031, China
The First Hospital Of Jilin University
Changchun, Jilin, 130031, China
Jilin Provincial People's Hospital
Changchun, Jilin, China
Xinhua Hospital affiliated to Dalian University
Dalian, Liaoning, 116023, China
Second People's Hospital of Huludao City
Huludao, Liaoning, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, 110004, China
First People's Hospital of Shenyang
Shenyang, Liaoning, 110041, China
Guyuan people's hospital
Guyuan, Ningxia, 756000, China
The Fifth People's Hospital of Ningxia Hui Autonomous Region
Shizuishan, Ningxia, 753000, China
The Second People's Hospital of Shizuishan
Shizuishan, Ningxia, 753000, China
Shizuishan First People's Hospital
Shizuishan, Ningxia, 753200, China
Second people's Hospital of shizuishan
Shizuishan, Ningxia, 753400, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750001, China
Yinchuan First People's Hospital
Yinchuan, Ningxia, 750001, China
Cardiovascular and Cerebrovoscular Hospital of General Hospital of Ningxia Med. Univ
Yinchuan, Ningxia, 750002, China
People's Hospital of Ningxia Hui Autonomous Region
Yinchuan, Ningxia, 750002, China
Zhongwei People's Hospital
Zhongwei, Ningxia, 755000, China
Baoji High-tech People's Hospital
Baoji, Shaanxi, 721000, China
weinan Central Hospital
Weinan, Shaanxi, 714000, China
Xi 'an Hi-tech Hospital
Xi'an, Shaanxi, 710000, China
Xi 'an Fengcheng Hospital
Xi'an, Shaanxi, 710016, China
Xian 141 Hospital
Xi'an, Shaanxi, 710089, China
Dezhou People's Hospital
Dezhou, Shandong, 2530000, China
Ningjin County People's Hospital
Dezhou, Shandong, 253400, China
Shandong Provincial Hospital
Jinan, Shandong, 250021, China
Liaocheng City Third People's Hospital
Liaocheng, Shandong, 252000, China
Liaocheng People's Hospital
Liaocheng, Shandong, 252000, China
Liaocheng Veterans Hospital
Liaocheng, Shandong, 252000, China
The Brain Hospital of Liaocheng People's Hospital
Liaocheng, Shandong, 252000, China
Guanxian People's Hospital
Liaocheng, Shandong, 252500, China
Liaocheng City Second People's Hospital
Liaocheng, Shandong, 252601, China
Dongchangfu people's Hospital
Liaocheng, Shandong, China
Liaocheng Central Hospital
Liaocheng, Shandong, China
Linqing People's Hospital
Linqing, Shandong, 252600, China
Qingdao Municipal Hospital
Qingdao, Shandong, 266000, China
Affiliated Hospital of Qingdao University Medical College
Qingdao, Shandong, 266071, China
Qingdao West Coast New Area People's Hospital
Qingdao, Shandong, 266400, China
Affiliated Hospital of Weifang Medical University
Weifang, Shandong, China
Sunshine Union Hospital
Weifang, Shandong, China
weihai Central Hospital
Weihai, Shandong, 264400, China
Wendeng District People's Hospital
Weihai, Shandong, 264400, China
Penglai People's Hospital
Yantai, Shandong, 265600, China
Yantai Beihai Hospita
Yantai, Shandong, 265701, China
Putuo District Central Hospital
Shanghai, Shanghai Municipality, 200062, China
Shanghai 7th People's Hospital
Shanghai, Shanghai Municipality, 200137, China
Changzhi People's Hospital
Changzhi, Shanxi, 046000, China
Heping Hospital affiliated to Changzhi Medical College
Changzhi, Shanxi, 046000, China
Datong Fifth People's Hospital
Datong, Shanxi, 037000, China
The Third People's Hospital of Datong
Datong, Shanxi, 037008, China
Shanxi cardiovascular disease hospital
Taiyuan, Shanxi, 030024, China
Shanxi Bethune Hospital
Taiyuan, Shanxi, 30000, China
Taiyuan Iron and Steel (Group) Co, Ltd,General Hospital
Taiyuan, Shanxi, 30001, China
The First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Xi 'an First Hospital
Xi’an, Shanxi, China
Shenzhen Integrated Chinese and Western Medicine Hospital
Shenzhen, Shenzhen, 100191, China
Shenzhen Luohu People's Hospital
Shenzhen, Shenzhen, 518001, China
Shenzhen Second People's Hospital
Shenzhen, Shenzhen, 518035, China
Huazhong University of Science and Technology Union Shenzhen Hospital
Shenzhen, Shenzhen, 518052, China
West China Hospital Of Sichuan University
Chengdou, Sichuan, 610041, China
Chengdu second Municipal People'sHospital
Chengdu, Sichuan, 610000, China
Sichuan Provincial People's Hospital
Chengdu, Sichuan, 610072, China
dazhou Central Hospital
Dazhou, Sichuan, 635099, China
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, 300052, China
First Affiliated Hospital of Xinjiang Medical University
Guiyang, Xinjiang Autonomous Region, 8300054, China
People's Hospital Of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang Autonomous Region, 830001, China
Friendship Hospital of Ili Kazak Autonomous Prefecture
Yining, Xinjiang Autonomous Region, 835000, China
First People's Hospital of Yunnan Province
Kunming, Yunnan, 650000, China
Hangzhou first people's Hospital
Hangzhou, Zhejiang, 310006, China
lishui municipal Central Hospital
Lishui, Zhejiang, 323000, China
Zhejiang Wenzhou Medical College Third Affiliated Hospital
Ruian, Zhejiang, 325200, China
Taizhou First People's Hospital
Taizhou, Zhejiang, 318020, China
Related Publications (22)
Zhao J, Tian X, Yang X, Xu Q, Xia X, Zhang Y, Xie X, Bath PM, Jing J, Wang Y, Meng X, Wang A. Effect of insulin resistance on ticagrelor-versus clopidogrel-based dual antiplatelet therapy for secondary prevention of stroke in carriers of CYP2C19 loss-of-function mutations. CMAJ. 2026 Jan 18;198(2):E36-E43. doi: 10.1503/cmaj.241581.
PMID: 41554550DERIVEDLin J, Zhou H, Wang Y, Jin A, Li S, Zhang L, Meng X, Xie X, Jing J, Jiang Y, Wang Y, Zhao X, Li H, Li Z, Wang Y; CHANCE-2 Investigators. Lp-PLA2 Activity and Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack. Stroke. 2026 Jan 13. doi: 10.1161/STROKEAHA.125.052954. Online ahead of print.
PMID: 41527826DERIVEDLi H, Xia X, Xu Q, Meng X, Wang Y, Wang A. Differential Effect of Ticagrelor Versus Clopidogrel by Causative Classification of Stroke Classification and Vascular Cellular Adhesion Molecule-1 Level on the Risk of Recurrent Stroke: A Post Hoc Analysis of the CHANCE-2 Trial. J Am Heart Assoc. 2026 Jan 6;15(1):e042259. doi: 10.1161/JAHA.125.042259. Epub 2025 Dec 18.
PMID: 41413755DERIVEDFeng Z, Zhang F, Jin A, Li X, Li Y, Chu Q, Xue J, Cheng A, Lin J, Li H, Meng X, Wang Y, Xu J. Genotype-guided dual antiplatelet therapy in minor stroke or transient ischemic attack with metabolic syndrome: A post hoc analysis of CHANCE-2. Diabetes Obes Metab. 2026 Jan;28(1):625-633. doi: 10.1111/dom.70243. Epub 2025 Oct 27.
PMID: 41145384DERIVEDLin X, Guo C, Meng X, Zhao X, Li H, Wang Y, Yang J. PCISOS Risk Profiles Stratify Heterogeneous Outcomes in Minor Posterior Circulation Ischemic Stroke: A Post Hoc Analysis of the CHANCE-2 Trial. Stroke. 2025 Dec;56(12):3371-3381. doi: 10.1161/STROKEAHA.125.053054. Epub 2025 Sep 10.
PMID: 40927840DERIVEDXie X, Jing J, Wang A, Xu Q, Zhao X, Lin J, Chen P, Jiang Y, Wang Y, Li H, Meng X, Wang Y. Dual antiplatelet therapy with ticagrelor vs clopidogrel in patients with TIA or minor stroke with or without symptomatic carotid artery stenosis: a post hoc analysis of the CHANCE-2 trial. Stroke Vasc Neurol. 2025 Oct 27;10(5):551-559. doi: 10.1136/svn-2024-003293.
PMID: 39773886DERIVEDXie X, Jing J, Meng X, Johnston SC, Bath PM, Li Z, Zhao X, Wang Y, Xu Q, Wang A, Jiang Y, Li H, Wang Y; CHANCE-2 Investigators. Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial. Stroke. 2024 Jul;55(7):1739-1747. doi: 10.1161/STROKEAHA.124.046834. Epub 2024 Jun 11.
PMID: 38860396DERIVEDWang A, Tian X, Xie X, Li H, Bath PM, Jing J, Lin J, Wang Y, Zhao X, Li Z, Liu L, Wang Y, Meng X. Differential effect of ticagrelor versus clopidogrel by homocysteine levels on risk of recurrent stroke: a post hoc analysis of the CHANCE-2 trial. CMAJ. 2024 Feb 11;196(5):E149-E156. doi: 10.1503/cmaj.231262.
PMID: 38346785DERIVEDZhang X, Jing J, Wang A, Xie X, Johnston SC, Li H, Bath PM, Xu Q, Lin J, Wang Y, Zhao X, Li Z, Jiang Y, Liu L, Chen W, Gong X, Li J, Han X, Meng X, Wang Y. Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial. Stroke Vasc Neurol. 2024 Nov 5;9(5):541-550. doi: 10.1136/svn-2023-002450.
PMID: 38286485DERIVEDMeng X, Wang A, Tian X, Johnston C, Li H, Bath PM, Xu Q, Zhang Y, Xie X, Jing J, Lin J, Wang Y, Zhao X, Li Z, Jiang Y, Liu L, Wang Y. One-Year Outcomes of Early Therapy With Ticagrelor vs Clopidogrel in CYP2C19 Loss-of-Function Carriers With Stroke or TIA Trial. Neurology. 2024 Feb 13;102(3):e207809. doi: 10.1212/WNL.0000000000207809. Epub 2024 Jan 5.
PMID: 38181311DERIVEDWang A, Tian X, Xie X, Li H, Jing J, Lin J, Wang Y, Zhao X, Li Z, Liu L, Wang Y, Meng X. Effects of remnant cholesterol on the efficacy of genotype-guided dual antiplatelet in CYP2C19 loss-of -function carriers with minor stroke or transient ischaemic attack: a post-hoc analysis of the CHANCE-2 trial. EClinicalMedicine. 2023 Dec 2;67:102357. doi: 10.1016/j.eclinm.2023.102357. eCollection 2024 Jan.
PMID: 38125963DERIVEDWang C, Jia W, Jing J, Meng X, Wang A, Xu Q, Zhang X, Pan Y, Xie X, Johnston SC, Bath PM, Lin J, Jiang Y, Li H, Wang Y, Zhao X, Liu L, Li Z, Wang Y; CHANCE-2 Investigators. Ticagrelor Versus Clopidogrel in Minor Stroke or Transient Ischemic Attack With Intracranial Artery Stenosis: A Post Hoc Analysis of CHANCE-2. J Am Heart Assoc. 2023 Nov 7;12(21):e031611. doi: 10.1161/JAHA.123.031611. Epub 2023 Oct 27.
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PMID: 33952670DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yongjun Wang, M.D
Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- President of Beijing Tiantan Hospital
Study Record Dates
First Submitted
July 8, 2019
First Posted
September 6, 2019
Study Start
September 23, 2019
Primary Completion
June 24, 2021
Study Completion
July 1, 2021
Last Updated
December 2, 2021
Record last verified: 2021-11
Data Sharing
- IPD Sharing
- Will not share