The Interactive Physical and Cognitive Exercise System
iPACES™
2 other identifiers
interventional
31
1 country
1
Brief Summary
This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise. In particular, this study will investigate the possible benefits of physical exercise (such as pedaling an under-table stationary elliptical) or mental exercise (such as playing a videogame on a portable tablet), or combining these activities together (as in the iPACES™ exergame).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2017
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 7, 2017
CompletedFirst Posted
Study publicly available on registry
March 3, 2017
CompletedStudy Start
First participant enrolled
March 4, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2022
CompletedMarch 31, 2020
March 1, 2020
5.3 years
February 7, 2017
March 29, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
executive function composite score
comprised of scores from Stroop, Trails, and Flanker
change over time from baseline to 3 months
Secondary Outcomes (2)
brain-derived neurotrophic factor (BDNF)
change over time from baseline to 3 months
Sit-Stand Test
change over time in score from baseline to 3 months
Study Arms (2)
physical, cognitive, then interactive
ACTIVE COMPARATORphysical exercise alone (PES) first, then iPACES
cognitive, physical, then interactive
ACTIVE COMPARATORcognitive exercise alone (iCE) first, then iPACES
Interventions
following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week physical exercise-only intervention, then 2-week cognitive exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)
following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)
following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise)
Eligibility Criteria
You may qualify if:
- co-residing older adults (e.g., spouses, partners, roommates, relatives)
- both at least 50 years of age
- normative/typical cognitive function or those with Mild Cognitive Impairment (MCI) or mild Neurocognitive Disorder (mNCD) or early Alzheimer's disease
- adequate vision and dexterity for on-screen assessments
- able to pedal an under-table elliptical
- permission of primary care provider and cardiologist (if applicable)
You may not qualify if:
- history of seizure
- Parkinson's disease
- significant dementia/memory loss
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Union College, New Yorklead
- 1st Playable Productionscollaborator
- Albany Medical Collegecollaborator
- Skidmore Collegecollaborator
- University of Illinois at Urbana-Champaigncollaborator
- National Institute on Aging (NIA)collaborator
Study Sites (1)
Healthy Aging & Neuropsychology Lab @ Union College
Schenectady, New York, 12308, United States
Related Publications (2)
Wall K, Stark J, Schillaci A, Saulnier ET, McLaren E, Striegnitz K, Cohen BD, Arciero PJ, Kramer AF, Anderson-Hanley C. The Enhanced Interactive Physical and Cognitive Exercise System (iPACESTM v2.0): Pilot Clinical Trial of an In-Home iPad-Based Neuro-Exergame for Mild Cognitive Impairment (MCI). J Clin Med. 2018 Aug 30;7(9):249. doi: 10.3390/jcm7090249.
PMID: 30200183RESULTAnderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clin Interv Aging. 2018 Sep 4;13:1565-1577. doi: 10.2147/CIA.S160756. eCollection 2018.
PMID: 30233154RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Cay Anderson-Hanley, PhD
Union College
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
February 7, 2017
First Posted
March 3, 2017
Study Start
March 4, 2017
Primary Completion
June 30, 2022
Study Completion
June 30, 2022
Last Updated
March 31, 2020
Record last verified: 2020-03
Data Sharing
- IPD Sharing
- Will not share