Physical Activity and Cognition Study

NCT02773121 | Completed

• 1 other identifier: H-34352
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this research study is to examine whether an intervention to increase physical activity using a body-worn sensor affects cognitive (thinking) processes.

Conditions

Aging

Keywords

Cognition; Learning; Memory; Executive Function; Attention; Neuropsychological Tests; Physical Activity; Physical Fitness; Exercise; Resistance Training; Walking; Muscle Stretching Exercises; Exercise Test; Balance; Flexibility; Body Composition

Outcome Measures

Primary Outcomes (2)

• Cognition

  Change in cognitive task performance post-intervention compared to baseline

  80-90 minutes

• Aerobic Fitness

  Change aerobic fitness measured with treadmill test post-intervention

  30 minutes

Secondary Outcomes (4)

• Functional fitness: Five Times Sit to Stand

  10 min

• Functional fitness: Timed Get Up and Go

  10 min

• Functional fitness: Flexibility

  10 min

• Physical activity

  12 weeks

Other Outcomes (3)

• Gait: step and stride time

  12 weeks

• Gait: stride time variability

  12 weeks

• Gait: gait symmetry

  12 weeks

Study Arms (2)

Physical activity monitoring

EXPERIMENTAL

Participants will wear a physical activity sensor on the hip or waist with a belt. They will be instructed to increase their physical activity level to at least 150 min of moderate-intensity physical activity per week. They will be asked to follow guidelines in the "Go4Life" brochure, website, and/or videos by the National Institute on Aging. Participants will receive weekly phone calls to monitor their progress, to provide feedback, and to suggest example exercises.

Behavioral: Physical Activity

Flexibility and balance

ACTIVE COMPARATOR

Participants will wear a physical activity sensor on the hip or waist with a belt. They will be instructed to increase their balance and flexibility over the 12 week period of the intervention. They will be asked to follow guidelines in the "Go4Life" brochure, website, and/or videos by the National Institute on Aging. Participants will receive weekly phone calls to monitor their progress, to provide feedback, and to suggest example exercises.

Behavioral: Physical Activity

Interventions

Physical Activity BEHAVIORAL

Trainer-guided at-home behavioral intervention

Flexibility and balance; Physical activity monitoring

Eligibility Criteria

• Age: 55 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-smoking
• Age between 55-85 years
• Sedentary status (physically inactive; not participating in at least 30 minutes of moderate intensity physical activity on at least three days per week for at least three months)
• Generally healthy men and women
• Living in the greater Boston area
• Available for the 4 month duration of the study
• Native-English speaking or fluent in English (must have attended elementary school and higher in English)

You may not qualify if:

• Poor vision that cannot be corrected with glasses or contact lenses
• Presence of an acute infection
• Diagnosis of kidney failure
• Diagnosis of liver disease
• Diagnosis of thyrotoxicosis/hyperthyroidism
• Diagnosis of cancer
• Past or present conditions that affect cognitive functioning:
• learning disability
• neurological disorders or conditions (movement disorder, history of head trauma or stroke, epilepsy, etc.)
• psychiatric disorders or conditions (depression, anxiety disorder, etc.)
• Past or present conditions that are counter indicators for participation in cardio-respiratory fitness assessment and moderate-intensity physical activity:
• heart conditions (e.g. heart attack, arrhythmias, etc.)
• circulatory conditions (e.g. uncontrolled hypertension, leg claudication, high cholesterol, etc.)
• respiratory conditions (e.g., asthma or lung conditions, such as chronic obstructive pulmonary disease, acute bronchitis, acute common cold, lung cancer, pneumonia, etc.)
• current musculoskeletal impairments (e.g. fractures, hemiplegia, chronic joint pain, arthritis, osteoporosis, not able to walk comfortably without assistance, etc.)

Sponsors & Collaborators

• Boston University: lead

Study Sites (1)

Boston University School of Medicine

Boston, Massachusetts, 02118, United States

Location

Related Publications (1)

• Kern KL, Storer TW, Schon K. Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging. Hum Brain Mapp. 2021 Mar;42(4):871-892. doi: 10.1002/hbm.25259. Epub 2020 Dec 16.

  PMID: 33325614 DERIVED

Related Links

• Brain Plasticity and Neuroimaging Laboratory at Boston University

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Karin Schon, Ph.D.

  Boston University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 11, 2016
• First Posted: May 16, 2016
• Study Start: March 1, 2017
• Primary Completion: January 17, 2020
• Study Completion: January 17, 2020
• Last Updated: April 21, 2020

Record last verified: 2020-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)