The Aerobic & Cognitive Exercise Study
ACES
The Cognitive Benefits of Interactive Mental and Physical Exercise for Older Adults at Risk for or With Mild Cognitive Impairment (MCI)
2 other identifiers
interventional
111
1 country
12
Brief Summary
The purpose of this study is to clarify the benefits to brain health and thinking processes that result from different forms of exercise. This study will examine the effectiveness of cybercycling (virtual reality enhanced stationary cycling) for persons at risk for and with MCI, and compare this with the individual cognitive, behavioral, and physiological effects of physical and mental exercise alone. The Investigators hypothesis that cognitive benefit will be greatest for combined aerobic and cognitive exercise compared to physical and mental exercise alone.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2014
Typical duration for not_applicable
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2014
CompletedFirst Submitted
Initial submission to the registry
September 4, 2014
CompletedFirst Posted
Study publicly available on registry
September 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2017
CompletedMay 3, 2018
April 1, 2018
2.8 years
September 4, 2014
April 30, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change from baseline in executive function at 6-months
Change in executive function from baseline at 6-months will be assessed by using a composite executive function score obtained from scores on Digit Span Backwards, Stroop, and Color Trails.
Baseline and 6-months
Secondary Outcomes (4)
Change in weight
Baseline, 3-months, 6-months, 1-year
Change in mood
Baseline, 3-months, 6-months, 1-year follow-up
Change from baseline in executive function at 3-months
Baseline and 3-months
Change from baseline in executive function at 1-year follow-up
Baseline and 1-year
Other Outcomes (4)
Change from baseline in BDNF at 6-months
Baseline and 6-months
Change from baseline in MRI at 6-months
Baseline and 6-months
Cognitive characteristics of sample pre- and post- intervention
Baseline and 6-months
- +1 more other outcomes
Study Arms (3)
Cybercycle-Game
EXPERIMENTALCombined aerobic \& cognitive exercise for 6 months, 3-5x/week.
Cybercyle-Tour
ACTIVE COMPARATORAerobic exercise only for 6 months, 3-5x/week.
Game Only
ACTIVE COMPARATORCognitive exercise only 6 months, 3-5x/week.
Interventions
Exercising on a virtual-reality enhanced stationary recumbent bicycle while playing interactive 3D video-game for 6 months, 3-5x/week.
Exercising on virtual-reality enhanced stationary recumbent bicycle and pedaling through interactive 3D scenic bike tours for 6 months, 3-5x/week.
While seated on a stationary recumbent seat play interactive 3D video-game for 6 months, 3-5x/week (no pedaling).
Eligibility Criteria
You may qualify if:
- age 50+
- able to pedal recumbent stationary bicycle
- available for regular exercise participation 3-5x/week for at least 6 months
- physician permission to exercise
You may not qualify if:
- unstable heart condition or other significant cardiovascular history (e.g,. stroke)
- meets criteria for Alzheimer's or other dementia
- significant history of other neurological disease (e.g., seizures, Parkinson's, etc.)
- physician denial to exercise
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Union College, New Yorklead
- National Institute on Aging (NIA)collaborator
Study Sites (12)
Albany Medical Center
Albany, New York, 12208, United States
Sidney Albert Albany Jewish Community Center
Albany, New York, 12208, United States
Stratton VA Medical Center
Albany, New York, 12208, United States
Hawthorne Ridge
East Greenbush, New York, 12061, United States
Guilderland YMCA
Guilderland, New York, 12084, United States
Glen Eddy
Niskayuna, New York, 12309, United States
Coburg Village
Rexford, New York, 12148, United States
Prestwick Chase
Saratoga Springs, New York, 12866, United States
Kingsway Parkland GardenApartments
Schenectady, New York, 12304, United States
Schaffer Heights
Schenectady, New York, 12308, United States
Sunnyview Rehabilitation Center
Schenectady, New York, 12308, United States
Beverwyck
Slingerlands, New York, 12159, United States
Related Publications (1)
Anderson-Hanley C, Barcelos NM, Zimmerman EA, Gillen RW, Dunnam M, Cohen BD, Yerokhin V, Miller KE, Hayes DJ, Arciero PJ, Maloney M, Kramer AF. The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial. Front Aging Neurosci. 2018 May 4;10:76. doi: 10.3389/fnagi.2018.00076. eCollection 2018.
PMID: 29780318DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Cay Anderson-Hanley, PhD
Union College
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
September 4, 2014
First Posted
September 11, 2014
Study Start
September 1, 2014
Primary Completion
July 1, 2017
Study Completion
July 1, 2017
Last Updated
May 3, 2018
Record last verified: 2018-04
Data Sharing
- IPD Sharing
- Will not share