Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

NCT03067181 | Recruiting Phase 3 FDA Drug

• 3 other identifiers: AGCT1531NCI-2017-00178U10CA180886
• Study Type: interventional
• Target: 1,780
• Locations: 9 countries
• Sites: 629

Brief Summary

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Conditions

Childhood Extracranial Germ Cell Tumor; Germ Cell Tumor; Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage I Testicular Embryonal Carcinoma AJCC v6 and v7; Stage I Testicular Seminoma AJCC v6 and v7; Stage I Testicular Yolk Sac Tumor AJCC v6 and v7; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7; Extragonadal Embryonal Carcinoma; Malignant Germ Cell Tumor; Malignant Ovarian Teratoma; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage I Testicular Choriocarcinoma AJCC v6 and v7; Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage II Testicular Choriocarcinoma AJCC v6 and v7; Stage II Testicular Embryonal Carcinoma AJCC v6 and v7; Stage II Testicular Yolk Sac Tumor AJCC v6 and v7; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7; Stage III Testicular Choriocarcinoma AJCC v6 and v7; Stage III Testicular Embryonal Carcinoma AJCC v6 and v7; Stage III Testicular Yolk Sac Tumor AJCC v6 and v7; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7; Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

Outcome Measures

Primary Outcomes (2)

• Overall survival

  The time from study entry to the date of death, or date of last contact and ascertained as alive, whichever comes first.

  Two years post enrollment

• Event-free survival

  The time from study entry to the date of death, date of disease progression or recurrence, date of second malignant neoplasm or date of last contact and ascertained as alive, whichever comes first.

  Two years post enrollment

Secondary Outcomes (3)

• Presence of hearing loss

  8 weeks after the last dose of platin therapy

• Adolescents and Young Adults-Hearing Screen (AYA HEARs)

  Baseline, end of therapy, 2 months post-end of therapy, and 1 year after enrollment

• Whole body lean body mass

  At diagnosis, at end of therapy, and up to 1 year after end of therapy

Other Outcomes (4)

• Event-free survival (EFS) for participants with and without tumor marker decline

  Up to 2 years

• Self-reported peripheral neuropathy score

  Up to 12 months after end of therapy

• Presence of residual tumor

  Up to 12 months

Study Arms (5)

Arm I (bleomycin, carboplatin, etoposide)

EXPERIMENTAL

Patients receive bleomycin IV over 10 minutes and carboplatin IV over 1 hour on day 1. Patients also receive etoposide IV over 1-2 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Biological: Bleomycin Sulfate; Drug: Carboplatin; Procedure: Computed Tomography; Drug: Etoposide; Procedure: Magnetic Resonance Imaging; Procedure: Pulmonary Function Test; Other: Questionnaire Administration

Arm II (bleomycin, etoposide, cisplatin)

EXPERIMENTAL

Patients receive bleomycin IV over 10 minutes on day 1. Patients also receive etoposide IV over 1-2 hours and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Biological: Bleomycin Sulfate; Drug: Cisplatin; Procedure: Computed Tomography; Drug: Etoposide; Procedure: Magnetic Resonance Imaging; Procedure: Pulmonary Function Test; Other: Questionnaire Administration

Arm III (bleomycin, etoposide, carboplatin)

EXPERIMENTAL

Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Biological: Bleomycin Sulfate; Drug: Carboplatin; Procedure: Computed Tomography; Drug: Etoposide; Procedure: Magnetic Resonance Imaging; Procedure: Pulmonary Function Test; Other: Questionnaire Administration

Arm IV (bleomycin, etoposide, cisplatin)

EXPERIMENTAL

Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study.

Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Biological: Bleomycin Sulfate; Drug: Cisplatin; Procedure: Computed Tomography; Drug: Etoposide; Procedure: Magnetic Resonance Imaging; Procedure: Pulmonary Function Test; Other: Questionnaire Administration

Low-Risk (observation)

EXPERIMENTAL

Patients with low-risk stage I grade 2, 3 ovarian immature teratoma or stage I non-seminoma or seminoma MGCTs undergo observation and can transfer to standard risk arm when eligibility criteria are met. Patients with stage I seminoma testicular MGCT undergo observation, and those with residual/recurrent disease are treated at the discretion of their physician. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial.

Other: Best Practice; Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration

Interventions

Magnetic Resonance Imaging PROCEDURE

Undergo MRI

Also known as: Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin); Low-Risk (observation)

Pulmonary Function Test PROCEDURE

Undergo a pulmonary function test

Also known as: lung function test, PFT, Pulmonary Function Testing, Pulmonary Function Tests

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin)

Questionnaire Administration OTHER

Ancillary studies

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin); Low-Risk (observation)

Biopsy Procedure PROCEDURE

Undergo a tumor biopsy

Also known as: Biopsy, BIOPSY_TYPE, Bx

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin); Low-Risk (observation)

Biospecimen Collection PROCEDURE

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin); Low-Risk (observation)

Bleomycin Sulfate BIOLOGICAL

Given IV

Also known as: Blanoxan, BleMomycine, Blenoxane, Bleo-cell, Bleo-S, Bleocin, Bleolem, Bleomycin Sulfas, Bleomycin Sulphate, Bleomycini Sulfas, Blexane, Oil Bleo

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin)

Carboplatin DRUG

Given IV

Also known as: Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo

Arm I (bleomycin, carboplatin, etoposide); Arm III (bleomycin, etoposide, carboplatin)

Cisplatin DRUG

Given IV

Also known as: Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin

Arm II (bleomycin, etoposide, cisplatin); Arm IV (bleomycin, etoposide, cisplatin)

Computed Tomography PROCEDURE

Undergo a CT scan

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, Diagnostic CAT Scan, Diagnostic CAT Scan Service Type, tomography

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin); Low-Risk (observation)

Etoposide DRUG

Given IV

Also known as: Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213

Arm I (bleomycin, carboplatin, etoposide); Arm II (bleomycin, etoposide, cisplatin); Arm III (bleomycin, etoposide, carboplatin); Arm IV (bleomycin, etoposide, cisplatin)

Best Practice OTHER

Undergo observation

Also known as: standard of care, standard therapy

Low-Risk (observation)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• There is no age limit for the low risk stratum (stage I ovarian immature teratoma and stage I non-seminoma or seminoma malignant GCT \[all sites\])
• Standard risk 1: Patients must be \< 11 years of age at enrollment
• Standard risk 2: Patients must be \>= 11 and \< 25 years of age at enrollment
• Patients enrolling on one of the low risk arms must be newly diagnosed with a stage I germ cell tumor; for the standard risk arms, patients must be newly diagnosed with malignant germ cell tumor (stage II or higher).
• Histologic confirmation of a primary extracranial germ cell tumor in any of the categories outlined below is required of all patients at enrollment , with the following exceptions:
• Among patients were initially diagnosed with completely resected non-seminoma malignant GCT and later recur during observation post surgery, a diagnostic biopsy is not required for enrollment if elevated tumor markers rise to \> 5 x upper limit of normal (ULN) on at least 2 measurements taken at least 1 week apart. The pathology report of initial surgery should be provided
• Patients may be enrolled without histologic or cytologic confirmation in the rare case where there are exceptionally raised tumor markers (alpha fetoprotein \[AFP- ≥ 500 ng/mL or HCG ≥ 500 IU/L) and radiologic features consistent with GCT. In addition, the treating clinician must deem that the patient's tumor is not suitable for upfront resection and that a biopsy is not in the patient's best interest; or that there is a need to start therapy urgently
• Low risk immature teratoma (IT); site: ovarian; stage: any; grade: any; histology: pure immature teratoma, mixed immature and mature teratoma, (may contain microscopic foci of yolk sac tumor \[\< 3 mm\], but no other pathological evidence of MGCT); tumor markers: alpha-FP =\< 1,000 ng/mL, beta-HCG institutional normal; all ages
• Low risk stage I non-seminoma MGCT; site: ovarian, testicular, or extragonadal; stage: COG stage I, FIGO stage IA and IB, American Joint Committee on Cancer (AJCC) testicular stage IA, IB and IS; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma (pure or mixed); all ages
• Low risk stage I seminoma-MGCT; site: testicular; stage: COG stage I; AJCC testicular stage IA IB, and IS; histology: must contain only seminoma; may contain immature/mature teratoma; may NOT contain yolk sac tumor, embryonal carcinoma, or choriocarcinoma; all ages
• Standard risk 1 (SR1); site: ovarian, testicular, or extragonadal; stage: COG stage II-IV, FIGO stage IC-IV, (International Germ Cell Consensus Classification \[IGCCC\] criteria DO NOT apply); histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \< 11
• Standard risk 2 (SR2)
• Site: ovarian; stage: COG stage II, III, and III-X, FIGO stage IC, II and III; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \>= 11 and \< 25
• Site: testicular; stage: COG stage II-IV, AJCC stage II, III, IGCCC good risk; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma: must be IGCCC good risk; post op: alpha-FP \< 1,000 ng/mL, beta-HCG \< 5,000 IU/mL and lactate dehydrogenase (LDH) \< 3.0 x normal; age (years) \>= 11 and \< 25
• Notes:

You may not qualify if:

• Patients with any diagnoses not listed including:
• Stage I testicular cancer patients who have undergone primary RPLND (retroperitoneal lymph node dissection)
• Pure ovarian or extragonadal dysgerminoma/seminoma
• Pure mature teratoma
• Pure immature teratoma with alpha-fetoprotein (AFP) \>= 1000 ng/mL
• "Poor risk" GCT (age \>= 11 years old and COG stage IV ovarian, COG stage II- IV extragonadal, or IGCCC intermediate or poor risk testicular), or
• Primary central nervous system (CNS) germ cell tumor
• Germ cell tumor with somatic malignant transformation
• Spermatocytic seminoma
• Patients must have had no prior systemic therapy for the current cancer diagnosis
• Patients must have had no prior radiation therapy with the exception of CNS irradiation of brain metastases; (this exception only applies to SR1 patients; any patients over age 11 with distant metastases to brain \[stage IV disease\] would be considered poor risk and therefore not eligible for this trial)
• Patients with significant, pre-existing co-morbid respiratory disease that contraindicate the use of bleomycin are ineligible for the standard risk arms of the trial
• Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs; a pregnancy test is required for female patients of childbearing potential; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])
• Lactating females who plan to breastfeed their infants; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])
• Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

Study Sites (629)

Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States

RECRUITING

USA Health Strada Patient Care Center

Mobile, Alabama, 36604, United States

SUSPENDED

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States

RECRUITING

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States

SUSPENDED

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States

RECRUITING

Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States

SUSPENDED

Katmai Oncology Group

Anchorage, Alaska, 99508, United States

RECRUITING

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

RECRUITING

Kingman Regional Medical Center

Kingman, Arizona, 86401, United States

RECRUITING

Banner Children's at Desert

Mesa, Arizona, 85202, United States

RECRUITING

Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States

ACTIVE NOT RECRUITING

Phoenix Childrens Hospital

Phoenix, Arizona, 85016, United States

RECRUITING

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States

ACTIVE NOT RECRUITING

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

ACTIVE NOT RECRUITING

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States

SUSPENDED

Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591, United States

RECRUITING

CARTI Cancer Center

Little Rock, Arkansas, 72205, United States

RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

ACTIVE NOT RECRUITING

Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States

RECRUITING

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States

ACTIVE NOT RECRUITING

PCR Oncology

Arroyo Grande, California, 93420, United States

RECRUITING

Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States

RECRUITING

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

RECRUITING

Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States

ACTIVE NOT RECRUITING

Mercy San Juan Medical Center

Carmichael, California, 95608, United States

ACTIVE NOT RECRUITING

Kaiser Permanente Downey Medical Center

Downey, California, 90242, United States

RECRUITING

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States

ACTIVE NOT RECRUITING

Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States

ACTIVE NOT RECRUITING

Kaiser Permanente-Fontana

Fontana, California, 92335, United States

RECRUITING

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

RECRUITING

Loma Linda University Medical Center

Loma Linda, California, 92354, United States

RECRUITING

Miller Children's and Women's Hospital Long Beach

Long Beach, California, 90806, United States

RECRUITING

Children's Hospital Los Angeles

Los Angeles, California, 90027, United States

RECRUITING

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States

RECRUITING

Los Angeles General Medical Center

Los Angeles, California, 90033, United States

ACTIVE NOT RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

ACTIVE NOT RECRUITING

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

Mattel Children's Hospital UCLA

Los Angeles, California, 90095, United States

RECRUITING

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States

SUSPENDED

Valley Children's Hospital

Madera, California, 93636, United States

RECRUITING

Providence Queen of The Valley

Napa, California, 94558, United States

RECRUITING

USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, 92663, United States

ACTIVE NOT RECRUITING

UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States

RECRUITING

Kaiser Permanente-Oakland

Oakland, California, 94611, United States

RECRUITING

Children's Hospital of Orange County

Orange, California, 92868, United States

RECRUITING

Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States

RECRUITING

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States

SUSPENDED

Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States

ACTIVE NOT RECRUITING

Kaiser Permanente-Roseville

Roseville, California, 95661, United States

ACTIVE NOT RECRUITING

Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States

ACTIVE NOT RECRUITING

Sutter Medical Center Sacramento

Sacramento, California, 95816, United States

ACTIVE NOT RECRUITING

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

RECRUITING

Kaiser Permanente-San Diego Mission

San Diego, California, 92108, United States

RECRUITING

Rady Children's Hospital - San Diego

San Diego, California, 92123, United States

RECRUITING

Naval Medical Center -San Diego

San Diego, California, 92134, United States

RECRUITING

UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States

RECRUITING

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States

ACTIVE NOT RECRUITING

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States

ACTIVE NOT RECRUITING

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States

ACTIVE NOT RECRUITING

Providence Medical Foundation - Santa Rosa

Santa Rosa, California, 95403, United States

RECRUITING

Providence Santa Rosa Memorial Hospital

Santa Rosa, California, 95405, United States

RECRUITING

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502, United States

ACTIVE NOT RECRUITING

Woodland Memorial Hospital

Woodland, California, 95695, United States

ACTIVE NOT RECRUITING

Children's Hospital Colorado

Aurora, Colorado, 80045, United States

RECRUITING

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

ACTIVE NOT RECRUITING

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States

ACTIVE NOT RECRUITING

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States

ACTIVE NOT RECRUITING

Memorial Hospital North

Colorado Springs, Colorado, 80920, United States

ACTIVE NOT RECRUITING

Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States

ACTIVE NOT RECRUITING

AdventHealth Porter

Denver, Colorado, 80210, United States

ACTIVE NOT RECRUITING

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, 80218, United States

RECRUITING

CommonSpirit Cancer Center Mercy

Durango, Colorado, 81301, United States

ACTIVE NOT RECRUITING

Mercy Medical Center

Durango, Colorado, 81301, United States

ACTIVE NOT RECRUITING

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

ACTIVE NOT RECRUITING

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States

ACTIVE NOT RECRUITING

Mountain Blue Cancer Care Center

Golden, Colorado, 80401, United States

SUSPENDED

UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States

SUSPENDED

Saint Anthony Hospital

Lakewood, Colorado, 80228, United States

ACTIVE NOT RECRUITING

AdventHealth Littleton

Littleton, Colorado, 80122, United States

ACTIVE NOT RECRUITING

UCHealth Lone Tree Health Center

Lone Tree, Colorado, 80124, United States

ACTIVE NOT RECRUITING

Longmont United Hospital

Longmont, Colorado, 80501, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States

SUSPENDED

Medical Center of the Rockies

Loveland, Colorado, 80538, United States

ACTIVE NOT RECRUITING

AdventHealth Parker

Parker, Colorado, 80138, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers-Parker

Parker, Colorado, 80138, United States

SUSPENDED

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States

ACTIVE NOT RECRUITING

Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado, 81008, United States

SUSPENDED

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States

SUSPENDED

Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States

RECRUITING

Yale University

New Haven, Connecticut, 06520, United States

RECRUITING

Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803, United States

RECRUITING

Kaiser Permanente-Capitol Hill Medical Center

Washington D.C., District of Columbia, 20002, United States

SUSPENDED

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States

ACTIVE NOT RECRUITING

Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States

RECRUITING

Broward Health Medical Center

Fort Lauderdale, Florida, 33316, United States

RECRUITING

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908, United States

RECRUITING

UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021, United States

RECRUITING

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207, United States

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States

RECRUITING

Nicklaus Children's Hospital

Miami, Florida, 33155, United States

RECRUITING

Miami Cancer Institute

Miami, Florida, 33176, United States

RECRUITING

AdventHealth Orlando

Orlando, Florida, 32803, United States

RECRUITING

Arnold Palmer Hospital for Children

Orlando, Florida, 32806, United States

RECRUITING

Nemours Children's Hospital

Orlando, Florida, 32827, United States

RECRUITING

Nemours Children's Clinic - Pensacola

Pensacola, Florida, 32504, United States

RECRUITING

Sacred Heart Hospital

Pensacola, Florida, 32504, United States

ACTIVE NOT RECRUITING

Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States

RECRUITING

Tampa General Hospital

Tampa, Florida, 33606, United States

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607, United States

RECRUITING

Saint Mary's Medical Center

West Palm Beach, Florida, 33407, United States

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329, United States

RECRUITING

Augusta University Medical Center

Augusta, Georgia, 30912, United States

RECRUITING

Atrium Health Navicent

Macon, Georgia, 31201, United States

RECRUITING

Memorial Health University Medical Center

Savannah, Georgia, 31404, United States

RECRUITING

Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States

RECRUITING

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States

SUSPENDED

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States

RECRUITING

Tripler Army Medical Center

Honolulu, Hawaii, 96859, United States

ACTIVE NOT RECRUITING

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

RECRUITING

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

RECRUITING

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

RECRUITING

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

RECRUITING

Rush-Copley Medical Center

Aurora, Illinois, 60504, United States

ACTIVE NOT RECRUITING

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

RECRUITING

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

RECRUITING

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

RECRUITING

SIH Cancer Institute

Carterville, Illinois, 62918, United States

RECRUITING

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

RECRUITING

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

RECRUITING

Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611, United States

RECRUITING

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States

SUSPENDED

Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States

SUSPENDED

University of Illinois

Chicago, Illinois, 60612, United States

RECRUITING

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States

RECRUITING

Carle at The Riverfront

Danville, Illinois, 61832, United States

ACTIVE NOT RECRUITING

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

RECRUITING

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

RECRUITING

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

RECRUITING

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

ACTIVE NOT RECRUITING

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

RECRUITING

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

RECRUITING

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

RECRUITING

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

RECRUITING

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

SUSPENDED

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

RECRUITING

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

RECRUITING

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

RECRUITING

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

ACTIVE NOT RECRUITING

Loyola University Medical Center

Maywood, Illinois, 60153, United States

RECRUITING

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

SUSPENDED

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269, United States

RECRUITING

Advocate Children's Hospital-Oak Lawn

Oak Lawn, Illinois, 60453, United States

RECRUITING

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

RECRUITING

Advocate Children's Hospital-Park Ridge

Park Ridge, Illinois, 60068, United States

RECRUITING

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

RECRUITING

OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States

RECRUITING

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

RECRUITING

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States

RECRUITING

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

RECRUITING

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

RECRUITING

Saint Jude Midwest Affiliate

Peoria, Illinois, 61637, United States

RECRUITING

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

RECRUITING

Valley Radiation Oncology

Peru, Illinois, 61354, United States

RECRUITING

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

RECRUITING

North Shore Medical Center

Skokie, Illinois, 60076, United States

SUSPENDED

Saint John's Hospital

Springfield, Illinois, 62702, United States

RECRUITING

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

RECRUITING

Springfield Clinic

Springfield, Illinois, 62702, United States

RECRUITING

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

RECRUITING

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States

SUSPENDED

Carle Cancer Center

Urbana, Illinois, 61801, United States

ACTIVE NOT RECRUITING

The Carle Foundation Hospital

Urbana, Illinois, 61801, United States

ACTIVE NOT RECRUITING

Illinois CancerCare - Washington

Washington, Illinois, 61571, United States

RECRUITING

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States

ACTIVE NOT RECRUITING

IU Health North Hospital

Carmel, Indiana, 46032, United States

SUSPENDED

Deaconess Clinic Downtown

Evansville, Indiana, 47713, United States

ACTIVE NOT RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

ACTIVE NOT RECRUITING

Riley Hospital for Children

Indianapolis, Indiana, 46202, United States

RECRUITING

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, Indiana, 46260, United States

RECRUITING

Chancellor Center for Oncology

Newburgh, Indiana, 47630, United States

ACTIVE NOT RECRUITING

Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States

SUSPENDED

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States

RECRUITING

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States

RECRUITING

Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States

ACTIVE NOT RECRUITING

Greater Regional Medical Center

Creston, Iowa, 50801, United States

RECRUITING

Blank Children's Hospital

Des Moines, Iowa, 50309, United States

RECRUITING

Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States

RECRUITING

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States

RECRUITING

Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States

SUSPENDED

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263, United States

RECRUITING

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States

RECRUITING

The Iowa Clinic PC

West Des Moines, Iowa, 50266, United States

RECRUITING

Wesley Medical Center

Wichita, Kansas, 67214, United States

RECRUITING

Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States

ACTIVE NOT RECRUITING

Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States

ACTIVE NOT RECRUITING

Saint Joseph Hospital

Lexington, Kentucky, 40504, United States

ACTIVE NOT RECRUITING

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States

ACTIVE NOT RECRUITING

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

ACTIVE NOT RECRUITING

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States

RECRUITING

Saint Joseph London

London, Kentucky, 40741, United States

ACTIVE NOT RECRUITING

Jewish Hospital

Louisville, Kentucky, 40202, United States

SUSPENDED

Norton Children's Hospital

Louisville, Kentucky, 40202, United States

RECRUITING

Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States

SUSPENDED

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

SUSPENDED

Saint Joseph Mount Sterling

Mount Sterling, Kentucky, 40353, United States

ACTIVE NOT RECRUITING

Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States

ACTIVE NOT RECRUITING

University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States

RECRUITING

Children's Hospital New Orleans

New Orleans, Louisiana, 70118, United States

RECRUITING

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States

RECRUITING

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

RECRUITING

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States

ACTIVE NOT RECRUITING

MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States

RECRUITING

Maine Children's Cancer Program

Scarborough, Maine, 04074, United States

RECRUITING

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States

RECRUITING

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

RECRUITING

Sinai Hospital of Baltimore

Baltimore, Maryland, 21215, United States

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

RECRUITING

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States

RECRUITING

Tufts Children's Hospital

Boston, Massachusetts, 02111, United States

SUSPENDED

Tufts Medical Center

Boston, Massachusetts, 02111, United States

RECRUITING

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

RECRUITING

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

RECRUITING

Baystate Medical Center

Springfield, Massachusetts, 01199, United States

RECRUITING

UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States

RECRUITING

C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States

RECRUITING

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States

RECRUITING

Bronson Battle Creek

Battle Creek, Michigan, 49017, United States

RECRUITING

Children's Hospital of Michigan

Detroit, Michigan, 48201, United States

RECRUITING

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States

ACTIVE NOT RECRUITING

Michigan State University

East Lansing, Michigan, 48823, United States

ACTIVE NOT RECRUITING

OSF Saint Francis Hospital and Medical Group

Escanaba, Michigan, 49829, United States

ACTIVE NOT RECRUITING

Hurley Medical Center

Flint, Michigan, 48503, United States

ACTIVE NOT RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

RECRUITING

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

RECRUITING

Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States

RECRUITING

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

RECRUITING

Lake Huron Medical Center

Port Huron, Michigan, 48060, United States

SUSPENDED

Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States

RECRUITING

Corewell Health Children's

Royal Oak, Michigan, 48073, United States

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

RECRUITING

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

RECRUITING

Munson Medical Center

Traverse City, Michigan, 49684, United States

RECRUITING

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

RECRUITING

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

ACTIVE NOT RECRUITING

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404, United States

RECRUITING

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States

RECRUITING

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

RECRUITING

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States

SUSPENDED

Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States

RECRUITING

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

RECRUITING

University of Missouri Children's Hospital

Columbia, Missouri, 65212, United States

RECRUITING

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

RECRUITING

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

SUSPENDED

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States

RECRUITING

Lake Regional Hospital

Osage Beach, Missouri, 65065, United States

RECRUITING

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

RECRUITING

Washington University School of Medicine

St Louis, Missouri, 63110, United States

RECRUITING

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

RECRUITING

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

RECRUITING

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

RECRUITING

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

RECRUITING

Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States

SUSPENDED

Fred and Pamela Buffett Cancer Center - Kearney

Kearney, Nebraska, 68845, United States

SUSPENDED

CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States

ACTIVE NOT RECRUITING

Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States

ACTIVE NOT RECRUITING

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114, United States

RECRUITING

Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States

ACTIVE NOT RECRUITING

Hematology and Oncology Consultants PC

Omaha, Nebraska, 68122, United States

SUSPENDED

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

ACTIVE NOT RECRUITING

Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States

ACTIVE NOT RECRUITING

Creighton University Medical Center

Omaha, Nebraska, 68131, United States

ACTIVE NOT RECRUITING

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

RECRUITING

Midlands Community Hospital

Papillion, Nebraska, 68046, United States

ACTIVE NOT RECRUITING

Carson Tahoe Regional Medical Center

Carson City, Nevada, 89703, United States

RECRUITING

Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States

SUSPENDED

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States

RECRUITING

Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States

RECRUITING

Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States

SUSPENDED

Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States

RECRUITING

Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States

RECRUITING

Las Vegas Urology - Pebble

Henderson, Nevada, 89074, United States

RECRUITING

Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States

RECRUITING

Las Vegas Urology - Pecos

Las Vegas, Nevada, 89074, United States

RECRUITING

Desert West Surgery

Las Vegas, Nevada, 89102, United States

SUSPENDED

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States

RECRUITING

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States

RECRUITING

Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States

RECRUITING

Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, 89106, United States

SUSPENDED

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States

RECRUITING

Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States

RECRUITING

Women's Cancer Center of Nevada

Las Vegas, Nevada, 89106, United States

RECRUITING

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109, United States

RECRUITING

Las Vegas Urology - Sunset

Las Vegas, Nevada, 89113, United States

RECRUITING

Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89113, United States

RECRUITING

Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States

RECRUITING

Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, 89121, United States

SUSPENDED

Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States

SUSPENDED

Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, 89128, United States

SUSPENDED

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

RECRUITING

Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, 89128, United States

RECRUITING

Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, 89128, United States

RECRUITING

OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States

RECRUITING

Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

RECRUITING

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States

RECRUITING

Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States

RECRUITING

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States

RECRUITING

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States

RECRUITING

Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States

SUSPENDED

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States

RECRUITING

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States

RECRUITING

University Cancer Center

Las Vegas, Nevada, 89169, United States

SUSPENDED

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States

RECRUITING

Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States

RECRUITING

Renown Regional Medical Center

Reno, Nevada, 89502, United States

RECRUITING

Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States

RECRUITING

Radiation Oncology Associates

Reno, Nevada, 89509, United States

RECRUITING

Cancer Care Specialists - Reno

Reno, Nevada, 89511, United States

SUSPENDED

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States

RECRUITING

Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States

RECRUITING

Morristown Medical Center

Morristown, New Jersey, 07960, United States

RECRUITING

Jersey Shore Medical Center

Neptune City, New Jersey, 07753, United States

RECRUITING

Saint Peter's University Hospital

New Brunswick, New Jersey, 08901, United States

RECRUITING

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903, United States

RECRUITING

Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States

RECRUITING

Saint Joseph's Regional Medical Center

Paterson, New Jersey, 07503, United States

RECRUITING

Presbyterian Hospital

Albuquerque, New Mexico, 87106, United States

RECRUITING

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

RECRUITING

Albany Medical Center

Albany, New York, 12208, United States

RECRUITING

Maimonides Medical Center

Brooklyn, New York, 11219, United States

RECRUITING

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

RECRUITING

Glens Falls Hospital

Glens Falls, New York, 12801, United States

ACTIVE NOT RECRUITING

NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States

RECRUITING

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040, United States

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

RECRUITING

Mount Sinai Hospital

New York, New York, 10029, United States

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States

RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

RECRUITING

University of Rochester

Rochester, New York, 14642, United States

ACTIVE NOT RECRUITING

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

RECRUITING

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

RECRUITING

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

RECRUITING

Children's Hospital at Montefiore

The Bronx, New York, 10467, United States

RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

RECRUITING

New York Medical College

Valhalla, New York, 10595, United States

RECRUITING

Westchester Medical Center

Valhalla, New York, 10595, United States

RECRUITING

Mission Hospital

Asheville, North Carolina, 28801, United States

RECRUITING

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

RECRUITING

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States

RECRUITING

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States

RECRUITING

Oncology Specialists of Charlotte

Charlotte, North Carolina, 28207, United States

SUSPENDED

Southern Oncology Specialists-Charlotte

Charlotte, North Carolina, 28262, United States

SUSPENDED

Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States

RECRUITING

Duke University Medical Center

Durham, North Carolina, 27710, United States

SUSPENDED

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States

RECRUITING

Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States

ACTIVE NOT RECRUITING

East Carolina University

Greenville, North Carolina, 27834, United States

RECRUITING

Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078, United States

SUSPENDED

Southern Oncology Specialists-Huntersville

Huntersville, North Carolina, 28078, United States

SUSPENDED

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States

RECRUITING

Matthews Radiation Oncology Center

Matthews, North Carolina, 28105, United States

SUSPENDED

Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105, United States

SUSPENDED

Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117, United States

SUSPENDED

Novant Health Cancer Institute - Rowan

Salisbury, North Carolina, 28144, United States

SUSPENDED

Rowan Regional Medical Center

Salisbury, North Carolina, 28144, United States

SUSPENDED

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

RECRUITING

Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States

RECRUITING

Children's Hospital Medical Center of Akron

Akron, Ohio, 44308, United States

RECRUITING

OhioHealth O'Bleness Hospital

Athens, Ohio, 45701, United States

RECRUITING

Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States

RECRUITING

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States

RECRUITING

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States

ACTIVE NOT RECRUITING

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

RECRUITING

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

ACTIVE NOT RECRUITING

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States

ACTIVE NOT RECRUITING

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States

ACTIVE NOT RECRUITING

Case Western Reserve University

Cleveland, Ohio, 44106, United States

RECRUITING

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106, United States

RECRUITING

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

RECRUITING

Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Mount Carmel East Hospital

Columbus, Ohio, 43213, United States

RECRUITING

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States

RECRUITING

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

RECRUITING

Grant Medical Center

Columbus, Ohio, 43215, United States

RECRUITING

The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States

RECRUITING

Mount Carmel Health Center West

Columbus, Ohio, 43222, United States

RECRUITING

Doctors Hospital

Columbus, Ohio, 43228, United States

RECRUITING

Dayton Children's Hospital

Dayton, Ohio, 45404, United States

RECRUITING

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States

RECRUITING

Grady Memorial Hospital

Delaware, Ohio, 43015, United States

RECRUITING

Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016, United States

RECRUITING

Dublin Methodist Hospital

Dublin, Ohio, 43016, United States

RECRUITING

Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States

RECRUITING

Saint Rita's Medical Center

Lima, Ohio, 45801, United States

RECRUITING

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

RECRUITING

Marietta Memorial Hospital

Marietta, Ohio, 45750, United States

RECRUITING

OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States

RECRUITING

Memorial Hospital

Marysville, Ohio, 43040, United States

RECRUITING

Knox Community Hospital

Mount Vernon, Ohio, 43050, United States

RECRUITING

Licking Memorial Hospital

Newark, Ohio, 43055, United States

RECRUITING

Mercy Health - Perrysburg Hospital

Perrysburg, Ohio, 43551, United States

RECRUITING

OhioHealth Pickerington Methodist Hospital

Pickerington, Ohio, 43147, United States

RECRUITING

Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States

RECRUITING

ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States

RECRUITING

Mercy Health - Saint Vincent Hospital

Toledo, Ohio, 43608, United States

RECRUITING

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States

RECRUITING

Saint Ann's Hospital

Westerville, Ohio, 43081, United States

RECRUITING

OhioHealth Westerville Medical Campus/Westerville Cancer Center

Westerville, Ohio, 43082, United States

RECRUITING

Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center

Wilmington, Ohio, 45177, United States

RECRUITING

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States

RECRUITING

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, 73505, United States

RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

RECRUITING

Saint Charles Health System

Bend, Oregon, 97701, United States

RECRUITING

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

RECRUITING

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

SUSPENDED

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

RECRUITING

Asante Rogue Regional Medical Center

Medford, Oregon, 97504, United States

SUSPENDED

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

RECRUITING

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Legacy Emanuel Children's Hospital

Portland, Oregon, 97227, United States

RECRUITING

Oregon Health and Science University

Portland, Oregon, 97239, United States

RECRUITING

Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States

ACTIVE NOT RECRUITING

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

RECRUITING

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

SUSPENDED

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

RECRUITING

Penn State Children's Hospital

Hershey, Pennsylvania, 17033, United States

RECRUITING

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, 19134, United States

RECRUITING

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States

RECRUITING

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237, United States

ACTIVE NOT RECRUITING

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States

ACTIVE NOT RECRUITING

Rhode Island Hospital

Providence, Rhode Island, 02903, United States

RECRUITING

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States

RECRUITING

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

RECRUITING

Prisma Health Richland Hospital

Columbia, South Carolina, 29203, United States

RECRUITING

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States

RECRUITING

Saint Francis Hospital

Greenville, South Carolina, 29601, United States

RECRUITING

BI-LO Charities Children's Cancer Center

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States

SUSPENDED

Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States

RECRUITING

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States

RECRUITING

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States

RECRUITING

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

RECRUITING

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

RECRUITING

North Grove Medical Park

Spartanburg, South Carolina, 29303, United States

RECRUITING

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

RECRUITING

Spartanburg Medical Center - Mary Black Campus

Spartanburg, South Carolina, 29307, United States

RECRUITING

SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States

RECRUITING

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

RECRUITING

T C Thompson Children's Hospital

Chattanooga, Tennessee, 37403, United States

RECRUITING

Memorial Hospital

Chattanooga, Tennessee, 37404, United States

SUSPENDED

Pulmonary Medicine Center of Chattanooga-Hixson

Hixson, Tennessee, 37343, United States

SUSPENDED

East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916, United States

RECRUITING

Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

RECRUITING

The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203, United States

RECRUITING

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States

RECRUITING

Memorial GYN Plus

Ooltewah, Tennessee, 37363, United States

SUSPENDED

Texas Tech University Health Sciences Center-Amarillo

Amarillo, Texas, 79106, United States

RECRUITING

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106, United States

SUSPENDED

Dell Children's Medical Center of Central Texas

Austin, Texas, 78723, United States

RECRUITING

Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States

ACTIVE NOT RECRUITING

Driscoll Children's Hospital

Corpus Christi, Texas, 78411, United States

RECRUITING

Medical City Dallas Hospital

Dallas, Texas, 75230, United States

RECRUITING

Parkland Memorial Hospital

Dallas, Texas, 75235, United States

SUSPENDED

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

RECRUITING

El Paso Children's Hospital

El Paso, Texas, 79905, United States

RECRUITING

Texas Tech University Health Sciences Center-El Paso

El Paso, Texas, 79905, United States

SUSPENDED

Cook Children's Medical Center

Fort Worth, Texas, 76104, United States

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States

RECRUITING

M D Anderson Cancer Center

Houston, Texas, 77030, United States

RECRUITING

Covenant Children's Hospital

Lubbock, Texas, 79410, United States

RECRUITING

UMC Cancer Center / UMC Health System

Lubbock, Texas, 79415, United States

RECRUITING

Texas Tech University Health Sciences Center-Lubbock

Lubbock, Texas, 79430, United States

ACTIVE NOT RECRUITING

Children's Hospital of San Antonio

San Antonio, Texas, 78207, United States

RECRUITING

Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229, United States

RECRUITING

University Hospital

San Antonio, Texas, 78229, United States

RECRUITING

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

RECRUITING

Scott and White Memorial Hospital

Temple, Texas, 76508, United States

RECRUITING

Primary Children's Hospital

Salt Lake City, Utah, 84113, United States

SUSPENDED

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States

ACTIVE NOT RECRUITING

University of Vermont Medical Center

Burlington, Vermont, 05401, United States

ACTIVE NOT RECRUITING

University of Vermont and State Agricultural College

Burlington, Vermont, 05405, United States

RECRUITING

University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States

RECRUITING

Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507, United States

RECRUITING

Naval Medical Center - Portsmouth

Portsmouth, Virginia, 23708-2197, United States

RECRUITING

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

RECRUITING

Carilion Children's

Roanoke, Virginia, 24014, United States

RECRUITING

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States

RECRUITING

Overlake Medical Center

Bellevue, Washington, 98004, United States

SUSPENDED

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

RECRUITING

Highline Medical Center-Main Campus

Burien, Washington, 98166, United States

ACTIVE NOT RECRUITING

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States

RECRUITING

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

RECRUITING

Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States

ACTIVE NOT RECRUITING

Providence Regional Cancer Partnership

Everett, Washington, 98201, United States

RECRUITING

Saint Francis Hospital

Federal Way, Washington, 98003, United States

ACTIVE NOT RECRUITING

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

RECRUITING

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

RECRUITING

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States

RECRUITING

Saint Clare Hospital

Lakewood, Washington, 98499, United States

ACTIVE NOT RECRUITING

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

RECRUITING

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States

ACTIVE NOT RECRUITING

Pacific Gynecology Specialists

Seattle, Washington, 98104, United States

SUSPENDED

Seattle Children's Hospital

Seattle, Washington, 98105, United States

RECRUITING

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States

RECRUITING

Kaiser Permanente Washington

Seattle, Washington, 98112, United States

ACTIVE NOT RECRUITING

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States

RECRUITING

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

RECRUITING

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States

SUSPENDED

Saint Michael Cancer Center

Silverdale, Washington, 98383, United States

ACTIVE NOT RECRUITING

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, 99204, United States

SUSPENDED

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204, United States

RECRUITING

MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, 99218, United States

SUSPENDED

MultiCare Deaconess Cancer and Blood Specialty Center - Valley

Spokane Valley, Washington, 99216, United States

SUSPENDED

Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States

ACTIVE NOT RECRUITING

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405, United States

RECRUITING

Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States

SUSPENDED

Madigan Army Medical Center

Tacoma, Washington, 98431, United States

RECRUITING

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States

SUSPENDED

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

RECRUITING

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States

RECRUITING

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States

SUSPENDED

United Hospital Center

Bridgeport, West Virginia, 26330, United States

SUSPENDED

West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States

RECRUITING

Edwards Comprehensive Cancer Center

Huntington, West Virginia, 25701, United States

RECRUITING

WVUH-Berkely Medical Center

Martinsburg, West Virginia, 25401, United States

SUSPENDED

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

RECRUITING

Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States

SUSPENDED

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, 54301-3526, United States

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States

SUSPENDED

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

RECRUITING

Holy Family Memorial Hospital

Manitowoc, Wisconsin, 54221, United States

SUSPENDED

Saint Vincent Hospital Cancer Center at Marinette

Marinette, Wisconsin, 54143, United States

SUSPENDED

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

RECRUITING

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154, United States

RECRUITING

HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, 53081, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States

RECRUITING

John Hunter Children's Hospital

Hunter Regional Mail Centre, New South Wales, 2310, Australia

RECRUITING

Sydney Children's Hospital

Randwick, New South Wales, 2031, Australia

RECRUITING

The Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia

RECRUITING

Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia

RECRUITING

Monash Medical Center-Clayton Campus

Clayton, Victoria, 3168, Australia

RECRUITING

Royal Children's Hospital

Parkville, Victoria, 3052, Australia

RECRUITING

Princess Margaret Hospital for Children

Perth, Western Australia, 6008, Australia

ACTIVE NOT RECRUITING

Perth Children's Hospital

Perth, Western Australia, 6009, Australia

RECRUITING

Alberta Children's Hospital

Calgary, Alberta, T3B 6A8, Canada

RECRUITING

University of Alberta Hospital

Edmonton, Alberta, T6G 2B7, Canada

RECRUITING

British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada

RECRUITING

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada

RECRUITING

Janeway Child Health Centre

St. John's, Newfoundland and Labrador, A1B 3V6, Canada

RECRUITING

IWK Health Centre

Halifax, Nova Scotia, B3K 6R8, Canada

RECRUITING

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5, Canada

RECRUITING

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada

RECRUITING

Children's Hospital

London, Ontario, N6A 5W9, Canada

RECRUITING

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1, Canada

RECRUITING

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada

RECRUITING

Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

RECRUITING

University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada

RECRUITING

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, H3H 1P3, Canada

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada

RECRUITING

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, G1V 4G2, Canada

RECRUITING

Tata Memorial Hospital

Mumbai, 400 012, India

RECRUITING

Tohoku University School of Medicine

Sendai, Aoba-ku, 980-8574, Japan

RECRUITING

Chiba University

Chiba-sgi, Chiba, 263-8522, Japan

RECRUITING

Niigata Cancer Centre

Niigata, Chuo-ku, 951-8566, Japan

RECRUITING

Kyushu Univeristy

Higashiku, Fukuoka, 812-8581, Japan

RECRUITING

Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan

RECRUITING

Hyogo Prefectural Kobe Children's Hospital

Kobe, Hyōgo, 650-0047, Japan

RECRUITING

University of Tsukuba Hospital

Tsukuba, Ibaraki, 305-8576, Japan

RECRUITING

Kanagawa Children's Medical Center

Yokohama, Kanagawa, 232-8555, Japan

RECRUITING

Saitama Children's Medical Center

Chuo-ku, Saitama, 330-8777, Japan

RECRUITING

Keio University

Shinjuku-ku, Tokyo, 160-8582, Japan

RECRUITING

Hiroshima University Hospital

Hiroshima, 734-8551, Japan

RECRUITING

Kyoto Perfectural University of Medicine

Kyoto, 602-8566, Japan

RECRUITING

Hyogo College of Medicine

Nishinomiya, Hyogo, 663-8501, Japan

SUSPENDED

Osaka City General Hospital

Osaka, 534-0021, Japan

RECRUITING

Saitama Medical University International Medical Center

Saitama, 350-1298, Japan

RECRUITING

National Cancer Center Hospital

Tokyo, 104 0045, Japan

RECRUITING

Kokuritsu Seiiku Medical Research Center Hospital

Tokyo, 157-8535, Japan

RECRUITING

Starship Children's Hospital

Grafton, Auckland, 1145, New Zealand

RECRUITING

Christchurch Hospital

Christchurch, 8011, New Zealand

RECRUITING

HIMA San Pablo Oncologic Hospital

Caguas, 00726, Puerto Rico

ACTIVE NOT RECRUITING

San Jorge Children's Hospital

San Juan, 00912, Puerto Rico

ACTIVE NOT RECRUITING

King Faisal Specialist Hospital and Research Centre

Riyadh, 11211, Saudi Arabia

SUSPENDED

Sheffield Children's Hospital

Broomhall, England, S10 2TH, United Kingdom

RECRUITING

Addenbrookes Hospital-Medical School

Cambridge, England, CB2 0QQ, United Kingdom

RECRUITING

Saint Bartholomew's Hospital

London, England, EC1A 7BE, United Kingdom

RECRUITING

University College London Hospitals NHS Trust - Foley Street

London, England, W1W 6DN, United Kingdom

RECRUITING

Royal Manchester Children Hospital

Manchester, England, M27 4HA, United Kingdom

RECRUITING

Royal Victoria Infirmary

Newcastle, England, NE1 4LP, United Kingdom

RECRUITING

Freeman Hospital

Newcastle upon Tyne, England, NE7 7DN, United Kingdom

RECRUITING

John Radcliffe Hospital

Oxford, England, OX3 9DU, United Kingdom

RECRUITING

Weston Park Hospital

Sheffield, England, S10 2SJ, United Kingdom

SUSPENDED

Saint James's University Hospital

West Yorkshire, England, LS9 7TF, United Kingdom

RECRUITING

Western General Hospital

Edinburgh, Scotland, EH4 2XU, United Kingdom

RECRUITING

Royal Hospital for Children and Young People

Edinburgh, Scotland, EH9 1LF, United Kingdom

RECRUITING

Beatson Oncology Center

Glasgow, Scotland, G12 0YN, United Kingdom

SUSPENDED

Royal Hospital for Children

Glasgow, Scotland, G51 4TF, United Kingdom

RECRUITING

Leeds General Infirmary

West Yorkshire, LS1 3EX, United Kingdom

RECRUITING

Related Publications (1)

• Trozzi R, Rosati A, Panico C, Perisiano C, Santoro A, Fagotti A. Extra-cranial meningioma associated with relapse of immature ovarian teratoma. Int J Gynecol Cancer. 2023 Oct 2;33(10):1649-1654. doi: 10.1136/ijgc-2023-004718. No abstract available.

  PMID: 37783480 DERIVED

MeSH Terms

Conditions

Neoplasms, Germ Cell and Embryonal; Carcinoma, Embryonal; Teratoma; Endodermal Sinus Tumor

Interventions

Practice Guidelines as Topic; Standard of Care; Biopsy; Specimen Handling; Bleomycin; Carboplatin; Cisplatin; 1,2-diaminocyclohexaneplatinum II citrate; Platinum; Etoposide; Magnetic Resonance Spectroscopy; Respiratory Physiological Phenomena

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Neoplasms; Mesonephroma

Intervention Hierarchy (Ancestors)

Guidelines as Topic; Quality Assurance, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation; Quality Indicators, Health Care; Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Investigative Techniques; Glycopeptides; Glycoconjugates; Carbohydrates; Peptides; Amino Acids, Peptides, and Proteins; Coordination Complexes; Organic Chemicals; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds; Metals, Heavy; Elements; Transition Elements; Metals; Podophyllotoxin; Tetrahydronaphthalenes; Naphthalenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Polycyclic Compounds; Glucosides; Glycosides; Spectrum Analysis; Chemistry Techniques, Analytical; Circulatory and Respiratory Physiological Phenomena

Study Officials

• A. L Frazier

  Children's Oncology Group

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2017
• First Posted: March 1, 2017
• Study Start: May 25, 2017
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: May 5, 2026

Record last verified: 2026-04

Locations

AU (8); JP (17); IN (1); GB (15); CA (17); NZ (2); PR (2); US (566); SA (1)