Pilot Study of the Impact of Exercise on Hippocampal Function

NCT03036371 | Completed

• 1 other identifier: 7418
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this pilot study is to test the procedural aspects of the behavioral tests and the exercise components of the study. This includes establishing typical scores for anxiety patients in these behavioral tests, and administering and coaching anxiety patients in an at-home exercise regimen. This pilot study will produce the information necessary to design a larger future study including both patients and healthy control participants.

Conditions

Anxiety

Keywords

Neurogenesis; Memory; Spatial Processing; Hippocampus; Cognition; Aerobic Exercise

Outcome Measures

Primary Outcomes (1)

• Change in Percent Correct Score for the Treasure Hunt Task (THT)

  change between baseline and 6 weeks

  6 weeks

Secondary Outcomes (4)

• Change in Percent Correct Score for the Mnemonic Similarity Test (MST)

  6 weeks

• Change in Depression, Anxiety, and Stress Scale (DASS)

  6 weeks

• Change in Intolerance of Uncertainty Scale (IUS)

  6 weeks

• Change in Baecke Physical Activity Questionnaire

  6 weeks

Study Arms (1)

High Intensity Interval Exercise

EXPERIMENTAL

home exercise sessions

Behavioral: High Intensity Interval Exercise

Interventions

High Intensity Interval Exercise BEHAVIORAL

6 week at-home aerobic exercise protocol

High Intensity Interval Exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• A primary diagnosis of Obsessive Compulsive Disorder (OCD), Social Anxiety Disorder (SAD), Generalized Anxiety Disorder (GAD), Panic Disorder (PD), and/or Specific Phobia (SP)
• No use of psychiatric medication in the past 4 weeks (or 8 weeks for fluoxetine)
• Age 18-40
• Ability to tolerate a treatment-free period
• English-speaking
• Body Mass Index (BMI) within normal range
• Willing and able to sign consent form and comply with study procedures

You may not qualify if:

• Current or lifetime comorbid psychiatric conditions that significantly elevate the risk of study participation
• Any major medical or neurological problem that might interfere with reliable performance of study tasks or their interpretation, or render participation dangerous
• Pregnant or lactating
• Use of medication that alters the brain
• Clinical symptom severity warranting immediate treatment
• Current rigorous exercise program
• Participation in Cognitive Behavioral Therapy (CBT) psychotherapy for anxiety

Sponsors & Collaborators

• New York State Psychiatric Institute: lead
• Columbia University: collaborator

Study Sites (1)

New York State Psychiatric Institute

New York, New York, 10032, United States

Location

MeSH Terms

Conditions

Anxiety Disorders; Spatial Processing

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Mental Disorders; Spatial Behavior; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Helen B Simpson, M.D, Ph.D.

  New York State Psychiatric Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Clinical Psychiatry

Study Record Dates

• First Submitted: January 3, 2017
• First Posted: January 30, 2017
• Study Start: March 28, 2017
• Primary Completion: September 13, 2018
• Study Completion: September 13, 2018
• Last Updated: March 27, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)