NCT03011489

Brief Summary

Newborns with unilateral cleft lip/ palate will be treated pre-surgically by Vacuum formed aligners in order to evaluate its effect on Nasoalveolar complex.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
14

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2017

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2017

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

January 4, 2017

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 5, 2017

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2017

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2017

Completed
Last Updated

April 25, 2017

Status Verified

April 1, 2017

Enrollment Period

5 months

First QC Date

January 4, 2017

Last Update Submit

April 22, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Parents' satisfaction

    It will be measured by questionnaire

    3 months

Secondary Outcomes (3)

  • Changes in Nasal morphology( Height, width, angulation of columella

    3 months

  • Changes in Interlabial gab

    3 months

  • Changes in Maxillary arch dimension

    3 months

Study Arms (2)

Vacuum formed aligners group

EXPERIMENTAL

This group will receive Vacuum formed aligners in addition to taping for 3 Months with follow-up every 1-2 weeks

Device: Vacuum formed aligners

control group

NO INTERVENTION

This group will not receive any treatment

Interventions

Infants will receive this appliance which is a maxillary plate with nasal stent in addition to taping on the upper lip (taping is a modified step in Figueroa's technique.

Vacuum formed aligners group

Eligibility Criteria

Age1 Week - 3 Months
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Non-syndromic Infants with complete unilateral cleft lip and palate
  • Infants less than 3 months of age
  • Males and females.
  • Infants with displaced alveolus
  • Patients whose parents provided written consent for the study.

You may not qualify if:

  • Patients above 3 months of age
  • Syndromic, malnourished and systemically ill infants.
  • Patients with bilateral cleft lip and palate.
  • Incomplete Cleft lip.
  • Medically compromised patients
  • Patient's/guardians who will be unwilling to go through the PNAM therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Cleft Lip

Condition Hierarchy (Ancestors)

Lip DiseasesMouth DiseasesStomatognathic DiseasesMouth AbnormalitiesStomatognathic System AbnormalitiesCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

  • Fatma Abdu Abdelsayed, professor

    Cairo University

    STUDY DIRECTOR

Central Study Contacts

Khadega Ali Al Khateeb, Master

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Master student, faculty of oral and dental medicine, Cairo university

Study Record Dates

First Submitted

January 4, 2017

First Posted

January 5, 2017

Study Start

January 1, 2017

Primary Completion

June 1, 2017

Study Completion

December 1, 2017

Last Updated

April 25, 2017

Record last verified: 2017-04

Data Sharing

IPD Sharing
Will not share