Chest Wall Motion Analysis in Disease

NCT02958683 | Completed

• 1 other identifier: 2010109TS
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest. Breathing movements may help with diagnosis, assessment of severity or assessing the impact of treatments for chest conditions. The investigators are following people who have a chest disease, measuring their chest wall motion and comparing it to their diagnosis and and how their treatment works. Chest wall motion can be measured in different ways at rest and whilst exercising. Small stickers on the chest can be used to reflect infra red light or visible squares of light can be shone onto the chest without using stickers.

Conditions

Mesothelioma; Lung Neoplasms; Surgery; Cystic Fibrosis; Pectus Carinatum; Pectus Excavatum; Empyema, Pleural; Pulmonary Disease, Chronic Obstructive

Keywords

Optoelectronic plethysmography; Structure light plethysmography; Respiratory Function Tests

Outcome Measures

Primary Outcomes (1)

• Change in volume of each thoracoabdominal compartment during breathing

  Measured in litres

  Baseline, follow up after normal clinical care up to 3 times (inpatient after surgery, 4-6 weeks, 3-12 months)

Secondary Outcomes (1)

• Synchrony of chest wall movement

  Baseline, follow up after normal clinical care up to 3 times (inpatient after surgery, 4-6 weeks, 3-12 months)

Study Arms (10)

Pectus excavatum

Patients with pectus excavatum (funnel chest) condition undergo chest wall motion analysis

Other: Chest wall motion analysis

Pectus carinatum

Patients with pectus carinatum (pigeon chest) condition undergo chest wall motion analysis

Other: Chest wall motion analysis

Chronic obstructive pulmonary disease

Patients affected by COPD undergo chest wall motion analysis

Other: Chest wall motion analysis

Diaphragm abnormality

Patients with abnormal function or structure of the diaphragm. Including diaphragmatic hernia/rupture and diaphragmatic paralysis undergo chest wall motion analysis

Other: Chest wall motion analysis

Healthy control

People who do not have any diagnosed thoracic condition and who do not have symptoms/signs suggestive of undiagnosed thoracic disease undergo chest wall motion analysis

Other: Chest wall motion analysis

Lung cancer

Patients with suspected or confirmed lung malignancy of all histological subtypes undergo chest wall motion analysis

Other: Chest wall motion analysis

Pleural disease

Patients with pleural thickening and/or pleural effusion, pneumothorax, empyema undergo chest wall motion analysis

Other: Chest wall motion analysis

Asthma

Patients diagnosed with asthma clinically or upon spirometry undergo chest wall motion analysis

Other: Chest wall motion analysis

Cystic fibrosis

Patients diagnosed with cystic fibrosis clinically or biochemically undergo chest wall motion analysis

Other: Chest wall motion analysis

Rib or sternal disease

Patients with an abnormality in the chest wall including fractures, osteomyelitis, malignancy of all histological subtypes, chest wall resection/reconstruction undergo chest wall motion analysis

Other: Chest wall motion analysis

Interventions

Chest wall motion analysis OTHER

Assessment of chest wall motion using novel technologies including: optoelectronic plethysmography (OEP), structured light plethysmography (SLP), Microsoft Kinnect

Asthma; Chronic obstructive pulmonary disease; Cystic fibrosis; Diaphragm abnormality; Healthy control; Lung cancer; Pectus carinatum; Pectus excavatum; Pleural disease; Rib or sternal disease

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients or their healthy acquaintances attending Heart of England NHS Foundation trust for care under the thoracic surgery department or respiratory department.

You may qualify if:

• Aged 16 or over
• Have thoracic disease or healthy control

You may not qualify if:

• Unable to provide valid informed consent

Sponsors & Collaborators

• Heart of England NHS Trust: lead
• University of Birmingham: collaborator
• University of Warwick: collaborator

Study Sites (1)

Heart of England NHS Foundation Trust

Birmingham, West Midlands, B95SS, United Kingdom

Location

Related Publications (2)

• Aliverti A, Pedotti A. Opto-electronic plethysmography. Monaldi Arch Chest Dis. 2003 Jan-Mar;59(1):12-6.

  PMID: 14533277 BACKGROUND

• Oswald N, Jalal Z, Kadiri S, Naidu B. Changes in chest wall motion with removal of Nuss bar in repaired pectus excavatum - a cohort study. J Cardiothorac Surg. 2019 Jan 8;14(1):4. doi: 10.1186/s13019-018-0827-1.

  PMID: 30621729 DERIVED

MeSH Terms

Conditions

Mesothelioma; Lung Neoplasms; Cystic Fibrosis; Pectus Carinatum; Funnel Chest; Empyema, Pleural; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Mesothelial; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases; Pancreatic Diseases; Digestive System Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infant, Newborn, Diseases; Bone Diseases, Developmental; Bone Diseases; Musculoskeletal Diseases; Cartilage Diseases; Musculoskeletal Abnormalities; Congenital Abnormalities; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Respiratory Tract Infections; Infections; Empyema; Suppuration; Pleural Diseases; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases, Obstructive; Chronic Disease; Disease Attributes

Study Officials

• Babu Naidu, MBBS

  Heart of England NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 5, 2016
• First Posted: November 8, 2016
• Study Start: July 1, 2011
• Primary Completion: July 31, 2015
• Study Completion: July 31, 2015
• Last Updated: February 22, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)