Key Insights

Highlights

Success Rate

90% trial completion (above average)

Published Results

294 trials with published results (22%)

Research Maturity

937 completed trials (69% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

8.0%

109 terminated out of 1360 trials

Success Rate

89.6%

+3.0% vs benchmark

Late-Stage Pipeline

16%

220 trials in Phase 3/4

Results Transparency

31%

294 of 937 completed with results

Key Signals

294 with results90% success109 terminated

Data Visualizations

Phase Distribution

950Total
Not Applicable (367)
Early P 1 (12)
P 1 (171)
P 2 (180)
P 3 (143)
P 4 (77)

Trial Status

Completed937
Unknown134
Terminated109
Recruiting81
Withdrawn39
Active Not Recruiting39

Trial Success Rate

89.6%

Benchmark: 86.5%

Based on 937 completed trials

Clinical Trials (1360)

Showing 20 of 20 trials
NCT06560463Recruiting

Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis

NCT02715921Not ApplicableCompletedPrimary

Impact of Telerehabilitation Training on Pediatric Cystic Fibrosis Patients: An Exploratory Study

NCT04687475Not ApplicableCompletedPrimary

Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis

NCT02417740RecruitingPrimary

Natural History of Noncirrhotic Portal Hypertension

NCT04798014CompletedPrimary

HERO-2: Home-Reported Outcomes With CFTR Modulator Therapy

NCT05331183Phase 3Active Not RecruitingPrimary

Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del

NCT05444257Phase 3Active Not RecruitingPrimary

A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy

NCT06654752Not ApplicableRecruitingPrimary

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

NCT03938324Not ApplicableCompleted

Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions

NCT00001532RecruitingPrimary

Role of Genetic Factors in the Development of Lung Disease

NCT07283770Phase 1RecruitingPrimary

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

NCT05453578Phase 1Completed

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

NCT00943514Recruiting

Natural History of Bronchiectasis

NCT04509050RecruitingPrimary

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

NCT05548283Phase 4RecruitingPrimary

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

NCT03256773Active Not RecruitingPrimary

High Resolution Micro OCT Imaging

NCT01293019Phase 3CompletedPrimary

Osteopathic Treatment in Adult Patients With Cystic Fibrosis

NCT06057714RecruitingPrimary

Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis

NCT05726994CompletedPrimary

Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF)

NCT03655223Active Not Recruiting

Early Check: Expanded Screening in Newborns

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Research Network

Activity Timeline