Key Insights

Highlights

Success Rate

67% trial completion

Published Results

44 trials with published results (21%)

Research Maturity

80 completed trials (38% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

18.8%

40 terminated out of 213 trials

Success Rate

66.7%

-19.9% vs benchmark

Late-Stage Pipeline

6%

12 trials in Phase 3/4

Results Transparency

55%

44 of 80 completed with results

Key Signals

44 with results67% success40 terminated

Data Visualizations

Phase Distribution

178Total
Not Applicable (16)
Early P 1 (5)
P 1 (86)
P 2 (59)
P 3 (8)
P 4 (4)

Trial Status

Completed80
Terminated40
Recruiting37
Unknown19
Active Not Recruiting17
Withdrawn9

Trial Success Rate

66.7%

Benchmark: 86.6%

Based on 80 completed trials

Clinical Trials (213)

Showing 20 of 20 trials
NCT03830229RecruitingPrimary

Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1

NCT06885697Phase 1RecruitingPrimary

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

NCT01950572Recruiting

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

NCT05932199Phase 1RecruitingPrimary

Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

NCT04334759Phase 3CompletedPrimary

DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma

NCT05873686Phase 1Active Not Recruiting

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

NCT04431024Recruiting

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

NCT07277413Phase 1Recruiting

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

NCT04981119Recruiting

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

NCT06581549CompletedPrimary

Immune Microenvironment and Gene Expression Profiling in Mesothelioma

NCT06057935Phase 2Recruiting

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

NCT05960773Phase 2RecruitingPrimary

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

NCT04031469Suspended

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease

NCT07705334Phase 1Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

NCT07824986Phase 3Not Yet Recruiting

A Phase 3 Trial in Advanced Epithelioid Mesothelioma

NCT05245500Phase 1RecruitingPrimary

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

NCT00715611Phase 2Active Not RecruitingPrimary

Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma

NCT05579366Phase 1Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

NCT05278975Phase 1Completed

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma

NCT02414269Phase 1Active Not Recruiting

Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin

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