NCT02879773|Completed
Computed Tomography Assessment of Regional Ventilation (CURVE)
CURVE
An Observational Study of Non Contrast Computed Tomography in Assessment of Regional Ventilation of the Lung.
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CURVE
An Observational Study of Non Contrast Computed Tomography in Assessment of Regional Ventilation of the Lung.
Sponsor study identifier
observational
131
1 country
1
Study Start
January 22, 2016
Actual (reported)Primary Completion
June 1, 2018
Actual (reported)Study Completion
July 31, 2019
Actual (reported)This study uses CT scans to assess airflow in the lung, the scan is quick, cheap and painless. The information from the scan may help doctors tell which patients are suitable to have surgery to cure early stage lung cancer. It may also help doctors tell which patients would benefit from surgery for emphysema and diagnose types of lung disease. The investigators will follow up patients who go through surgery to test how well the scan predicts the function of the lung after surgery. The investigators will follow patients being investigated for lung disease to test how accurate the scan is at the getting the diagnosis right.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 31, 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 22, 2016
Actual (reported)August 5, 2016
Actual (reported)August 26, 2016
Actual (reported)June 1, 2018
Actual (reported)July 31, 2019
Actual (reported)Percentage of eligible patients screened who consent to participate
2 years
Change in gas transfer
3-6 months
Change in FEV1
3-6 months
Diagnosis
3-6 months
Patients undergoing thoracic surgery for suspected or confirmed lung cancer; including wedge resection, segmentectomy, lobectomy, bilobectomy or pneumonectomy. CTPVe will be modelled to predict postoperative lung function.
Patients undergoing assessment of emphysema/chronic obstructive pulmonary disease (COPD) for potential surgical intervention; including lung volume reduction surgery, endobronchial valve insertion or endobronchial coil insertion. CTPVe will be modelled to predict postoperative lung function.
Patients undergoing assessment or treatment of suspected or confirmed interstitial lung disease. CTPVe will be modelled to aid diagnosis of the subtype of interstitial lung disease confirmed by histological diagnosis.
Non contrast computed tomography (CTPVe) scan during end inspiration and end expiration in supine position
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
The study population will be adults being assessed or treated in a hospital with a patient case mix and size typical of thoracic practice in England. As a tertiary referral centre patients will come from a wide geographical range and from both rural and urban settings.
Heart of England NHS Foundation Trust
Birmingham, West Midlands, B95SS, United Kingdom
Aliverti A, Pennati F, Salito C, Woods JC. Regional lung function and heterogeneity of specific gas volume in healthy and emphysematous subjects. Eur Respir J. 2013 May;41(5):1179-88. doi: 10.1183/09031936.00050112. Epub 2012 Aug 9.
Babu Naidu, MBBS
Heart of England NHS Foundation Trust
131 participants (actual enrollment reported by the registry).
First Submitted
August 5, 2016
First Posted
August 26, 2016
Study Start
January 22, 2016
Actual (reported)Autologous Stem Cell Treatment for Chronic Lung Disease Study
Change in perception of breathlessness
3-6 months
Regional ventilation
3-6 months
Contact the study team to confirm eligibility.
Primary Completion
June 1, 2018
Actual (reported)Study Completion
July 31, 2019
Actual (reported)Last Updated
February 11, 2020
Record last verified: 2020-02
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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