Effect of Anthocyanins Extracted From Purple Potatoes on Healthy Study Subjects' Postprandial Glycemia and Insulinemia

NCT02940080 | Completed

• 1 other identifier: Siniset perunat 2
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

A randomized, single-blind cross-over clinical nutrition trial will be conducted. The effects of yellow-fleshed potatoes and yellow-fleshed potatoes supplemented with anthocyanins extracted from purple-fleshed potatoes on healthy men's postprandial glycemia and insulinemia will be compared. Additionally, the postprandial metabolism and metabolites, and the appearance and metabolism of the flavonoids and their metabolites is studied in plasma, urine and feces.

Conditions

Postprandial Glycemia

Outcome Measures

Primary Outcomes (2)

• Plasma glucose concentration

  0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

• Plasma insulin concentration

  0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

Secondary Outcomes (5)

• Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in plasma (NMR and (U)HPLC-MS/MS measurements)

  0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

• Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in urine (NMR and (U)HPLC-MS/MS measurements)

  Before meal, and 0-4h, 4-8h, 8-16h, 16-24 h

• Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in feces (NMR and (U)HPLC-MS/MS measurements)

  before and after meal

• Area under the glucose concentration curve (AUC)

  0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

• Area under the insulin concentration curve (AUC)

  0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

Study Arms (2)

Anthocyanins and yellow potato

EXPERIMENTAL

168 mg of anthocyanins extracted from purple-fleshed potatoes added to 350 g of steam-cooked mashed potatoes in water

Other: Dietary

Yellow potato

EXPERIMENTAL

350 g of steam-cooked mashed potatoes in water

Other: Dietary

Interventions

Dietary OTHER

Anthocyanins and yellow potato; Yellow potato

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-45
• Male
• No regular medication
• No participation in a drug trial or blood donation within 2 months
• Non-smoker
• Signs informed consent
• Body mass index 18.5-27 kg/m2
• Fasting plasma cholesterol \< 5.5 mmol/l
• Fasting plasma triacylglycerols \< 2.6 mmol/l
• Fasting plasma glucose 4-6 mmol/l
• blood pressure \<140/80 mmHg
• hemoglobin\>130 g/l
• Fasting plasma alanine amino transferase (ALAT) \<60 U/l (normal liver function)
• Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• Fasting plasma creatinine \<118 µmol/l (normal kidney function)

You may not qualify if:

• Regular smoking
• Alcohol abuse
• Regular medication

Sponsors & Collaborators

• University of Turku: lead

Study Sites (1)

Department of Biochemistry, University of Turku

Turku, 20014, Finland

Location

MeSH Terms

Interventions

Diet

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Kaisa M Linderborg, PhD

  Department of Biochemistry, University of Turku

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 13, 2016
• First Posted: October 20, 2016
• Study Start: October 1, 2016
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: March 14, 2022

Record last verified: 2022-03

Locations

FI (1)