Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

NCT02931812 | Unknown DMC

• 1 other identifier: 2014-A00254-43
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

Conditions

Cirrhosis; Food Preferences; Taste Disorders; Protein-Energy Malnutrition; Chronic Renal Failure

Keywords

cirrhosis; reward system; taste sensitivity; chronic renal failure

Outcome Measures

Primary Outcomes (4)

• Energy expenditure

  evice: indirect calorimetry (sensormedics)

  two years

• body composition

  Device: Multifrequency bio-impedancemetry (aminostats)

  2 years

• amino acids profil in plasma

  Biological measurments

  2 years

• Food preferences

  Device: Treshold taste detection

  2 years

Study Arms (3)

Cirrhotic subjects

15 cirrhotic patients in end-stage in waiting a graft

Chronic kidney disease subjects

15 chronic kidney disease patients in end-stage in waiting a graft

Healthy subjects

30 healthy subjects to compare

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* 15 patients waiting for renal transplantation * 15 patients waiting for liver transplantation * 30 healthy subjects matched for gender, age and body mass index

You may qualify if:

• written consent
• patients in waiting renal transplant
• patients in waiting liver transplant

You may not qualify if:

• chronic infection
• acute infection
• cancer
• antibiotic treatments
• alcool abuse
• pregnant woman
• specific or restrictive diet

Sponsors & Collaborators

• University of Burgundy: lead

Study Sites (1)

Center for Taste and Feeding Behaviour

Dijon, Burgundy, 21000, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples for hormones measurments (leptine, ghrelin, insulin) and plasmatic amino-acids

MeSH Terms

Conditions

Fibrosis; Food Preferences; Taste Disorders; Protein-Energy Malnutrition; Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Feeding Behavior; Behavior; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Protein Deficiency; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes

Central Study Contacts

Laurent Brondel, Professor

CONTACT

03 80 29 34 84; laurent.brondel@u-bourgogne.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 3, 2016
• First Posted: October 13, 2016
• Study Start: May 1, 2014
• Primary Completion: May 1, 2020
• Study Completion: December 1, 2022
• Last Updated: October 8, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)