NCT02899676

Brief Summary

The aim of this study was to identify neural correlates involved in arthmetics processing in adults and children aged 8 to 14 with normal cognitive function. Brain area will be identified by functional magnetic resonance imaging (IRMf).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
79

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2014

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 18, 2014

Completed
2.5 years until next milestone

First Submitted

Initial submission to the registry

September 2, 2016

Completed
12 days until next milestone

First Posted

Study publicly available on registry

September 14, 2016

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 9, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 9, 2018

Completed
Last Updated

December 19, 2025

Status Verified

December 1, 2025

Enrollment Period

4.1 years

First QC Date

September 2, 2016

Last Update Submit

December 13, 2025

Conditions

Neural Bases of Arithmetic Processing

Outcome Measures

Primary Outcomes (1)

  • Brain area activity in arithmetic processing will be identified by IRMf

    Brain activity is identified by IRMf

    up to 60 days after inclusion

Secondary Outcomes (1)

  • Parietal region activity in arithmetic processing will be identified by IRMf

    up to 60 days after inclusion

Study Arms (3)

Healthy subjects aged 18 to 24

EXPERIMENTAL

Subjects without neurological or psychiatric history

Other: neuropsychological testingOther: functional magnetic resonance imagingOther: simple arithmetic operations

Healthy subjects aged 8 to 11

EXPERIMENTAL

Subjects without neurological or psychiatric history

Other: neuropsychological testingOther: functional magnetic resonance imagingOther: simple arithmetic operations

Healthy subjects aged 12 to 14

EXPERIMENTAL

Subjects without neurological or psychiatric history

Other: neuropsychological testingOther: functional magnetic resonance imagingOther: simple arithmetic operations

Interventions

functional magnetic resonance imagingOTHER
Also known as: IRMf
Healthy subjects aged 12 to 14Healthy subjects aged 18 to 24Healthy subjects aged 8 to 11
simple arithmetic operationsOTHER
Healthy subjects aged 12 to 14Healthy subjects aged 18 to 24Healthy subjects aged 8 to 11
neuropsychological testingOTHER
Healthy subjects aged 12 to 14Healthy subjects aged 18 to 24Healthy subjects aged 8 to 11

Eligibility Criteria

Age8 Years - 24 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • children aged 8 to 14 with parents' consent
  • adults aged 18 to 24
  • right-handed
  • affiliated to the French social security

You may not qualify if:

  • known neurological disorders including epilepsia
  • known psychiatric disorders including Attention Deficit Disorder
  • birth complications needing intensive care
  • central nervous system treatment
  • important hearing disabilities
  • not corrected impaired vision

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Médecine nucléaire, Groupement Hospitalier Est, HCL

Bron, 69677, France

Location

Related Publications (1)

  • Mathieu R, Epinat-Duclos J, Leone J, Fayol M, Thevenot C, Prado J. Hippocampal spatial mechanisms relate to the development of arithmetic symbol processing in children. Dev Cogn Neurosci. 2018 Apr;30:324-332. doi: 10.1016/j.dcn.2017.06.001. Epub 2017 Jun 13.

    PMID: 28648549RESULT

MeSH Terms

Interventions

Neuropsychological Tests

Intervention Hierarchy (Ancestors)

Psychological TestsBehavioral Disciplines and Activities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 2, 2016

First Posted

September 14, 2016

Study Start

March 18, 2014

Primary Completion

May 9, 2018

Study Completion

May 9, 2018

Last Updated

December 19, 2025

Record last verified: 2025-12

Locations

FR(1)