Functional Magnetic Resonance Imaging Study of the Central Auditory System After Single Sided Deafness

NCT02534298 | Completed DMC

• 2 other identifiers: RC31/13/020413 204 02
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The objective is to study the relation between the reorganization of the central auditory system, and the psychophysical deficits in binaural hearing in subjects with single sided deafness.

Conditions

Unilateral Hearing Loss

Keywords

single sided deafness.; Auditory plasticity; Asymmetrical hearing loss; Cochlear implants; Inter hemispheric asymmetry; Lateralization index; Dichotic hearing

Outcome Measures

Primary Outcomes (2)

• Lateralization index

  ratio of the BOLD signal (blood oxygenation level dependent) obtained at the superior temporal cortex in response to stimulation of the monaural sound to the ear BOLD signal obtained for the same stimulus presented binaurally

  4 weeks

• Speech Reception Threshold

  signal / noise ratio for the recognition of 50% of the words in dichotic hearing

  4 weeks

Secondary Outcomes (3)

• SRT in reverse dichotic hearing, mean localization error angle

  4 weeks

• the percentage of errors in test horizontal location of the sound source

  4 weeks

• seniority of deafness

  inclusion

Study Arms (2)

single sided deafness

EXPERIMENTAL

single sided deafness and asymmetrical hearing loss patients functional magnetic resonance imaging

Other: functional magnetic resonance imaging

control group

OTHER

Normal hearing subject functional magnetic resonance imaging

Other: functional magnetic resonance imaging

Interventions

functional magnetic resonance imaging OTHER

functional magnetic resonance imaging

control group; single sided deafness

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Right-handed subjects
• SSD confirmed using evoked auditory potentials

You may not qualify if:

• Associated neurological disorder

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

University Hospital of Toulouse

Toulouse, 31000, France

Location

Related Publications (1)

• Vannson N, James CJ, Fraysse B, Lescure B, Strelnikov K, Deguine O, Barone P, Marx M. Speech-in-noise perception in unilateral hearing loss: Relation to pure-tone thresholds and brainstem plasticity. Neuropsychologia. 2017 Jul 28;102:135-143. doi: 10.1016/j.neuropsychologia.2017.06.013. Epub 2017 Jun 13.

  PMID: 28623107 RESULT

MeSH Terms

Conditions

Hearing Loss, Unilateral

Condition Hierarchy (Ancestors)

Hearing Loss; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mathieu Marx, MD

  University Hospital of Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2015
• First Posted: August 27, 2015
• Study Start: April 1, 2015
• Primary Completion: April 1, 2016
• Study Completion: April 1, 2016
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

FR (1)